The effect of nonsteroidal anti-inflammatory drugs on ovulation: A prospective, randomized clinical trial

Fertility and Sterility

Volumn 76, Issue 5, 2001, Pages 957-961

  Uhler, Meike L ^a   Hsu, Judith W ^a   Fisher, Susan G ^a   Zinaman, Michael J ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Follicular rupture; Ibuprofen; Ovary; Progesterone; Ultrasonography; Urinary LH test

Indexed keywords

IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO;

ADULT; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ECCHYMOSIS; FEMALE; HUMAN; HUMAN EXPERIMENT; LUTEINIZING HORMONE RELEASE; NORMAL HUMAN; OVARY FOLLICLE; OVULATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROSTAGLANDIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; TASTE; TRANSVAGINAL ECHOGRAPHY;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IBUPROFEN; OVARIAN FOLLICLE; OVULATION; PROSPECTIVE STUDIES; TIME FACTORS;

EID: 0034754937     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(01)02829-1     Document Type: Conference Paper

References (20)

1. Armstrong DT. Prostaglandins and follicular functions. J Reprod Fertil 1981;62:283-91.
2. Priddy AR, Killick SR. Eicosanoids and ovulation. Prostaglandins Leukot Essent Fatty Acids 1993;49:827-31.
3. Lindner HR, Zor U, Kohen F, Bauminger S, Amsterdam A, Lahav M, et al. Significance of prostaglandins in the regulation of cyclic events in the ovary and uterus. Adv Prostaglandin Thromboxane Res 1980;8: 1371-90.
4. Seibel MM, Swartz SL, Smith D, Levesque L, Taymor ML. In vivo prostaglandin concentrations in human preovulatory follicles. Fertil Steril 1984;42;482-5.
5. Espey LL, Norris C, Saphire D. Effect of time and dose of indomethacin on follicular prostaglandins and ovulation in the rabbit. Endocrinol 1986;119:746-54.
6. Zanagnolo V, Dharmarajan AM, Endo K, Wallach EE. Effects of acetylsalicylic acid (aspirin) and naproxen sodium (naproxen) on ovulation, prostaglandin, and progesterone production in the rabbit. Fertil Steril 1996;65:1036-43.
7. Katz E, Dharmarajan AM, Sueoka K, Ghodgaonkar RB, Dubin NH, Wallach EE. Effects of systemic administration of indomethacin on ovulation, luteinization, and steroidogenesis in the rabbit ovary. Am J Obstet Gynecol 1989;161:1361-6.
8. Carlson JC, Barcikowski B, Cargill V, McCracken JA. The blockade of LH release by indomethacin. J Clin Endocrinol Metab 1974;39:399-402.
9. Maia H, Barbosa I, Coutinho EM. Inhibition of ovulation in marmoset monkeys by indomethacin. Fertil Steril 1978;29:565-70.
10. Murdoch WJ, Cavender JL. Effect of indomethacin on the vascular architecture of preovulatory ovine follicles: possible implication in the luteinized unruptured follicle syndrome. Fertil Steril 1989;51:153-5.
11. Miyazaki T, Dharmarajan AM, Atlas SJ, Katz E, Wallach EE. Do prostaglandins lead to ovulation in the rabbit by stimulating proteolytic enzyme activity? Fertil Steril 1991;55:1183-8.
12. Kranzfelder D, Reich R, Abisogun O, Tsafriri A. Preovulatory changes in the perifollicular capillary network in the rat: role of eicosanoids. Biol Reprod 1992;46:379-85.
13. Pnddy AR, Killick ST, Elstein M, Morris J, Sullivan M, Patel L, et al. The effect of prostaglandin synthetase inhibitors on human preovulatory follicular fluid prostaglandin, thromboxane, and leukotriene concentrations. J Clin Endocrinol Metab 1990;71:235-42.
14. Athanasiou S, Bourne TH, Khalid A, Okokon EV, Crayford T, Hagstrom HG. Effects of indomethacin on follicular structure, vascularity, and function of the periovulatory period in women. Fertil Steril 1996; 65:556-60.
15. Kenn JF, Kirby C, Morris D, McEvoy M, Ward B, Cox LW. Incidence of luteinized unruptured follicle phenomenon in cycling women. Fertil Steril 1983;40:620-6.
16. Hamilton CJCM, Wetzels LCG, Evers JLH, Hoogland HJ, Muijtjens A, de Haan J. Follicle growth curves and hormonal patterns in patients with the luteinized unruptured follicle syndrome. Fertil Steril 1985;43: 541-8.
17. Toppozada M, El-Abd M, El-Sokkary H, El-Rahman HA. Effect of a prostaglandin inhibitor of human ovulation. Singapore J Obstet Gynecol 1979;10:42-6.
18. Lundstrom V, Landgren BM, Eneroth P, Johannisson E. The effect of a prostaglandin synthetase inhibitor on the hormonal profile and the endometrium in women. Acta Obstet Gynecol Scand Suppl 1983;113: 77-80.
19. Killick S, Elstein M. Pharmacologic production of luteinized unruptured follicles by prostaglandin synthetase inhibitors. Fertil Steril 1987; 47:773-7.
20. Smith G, Roberts R, Hall C, Nuki G. Reversible ovulatory failure associated with the development of luteinized unruptured follicles in women with inflammatory arthritis taking non-steroidal anti-inflammatory drugs. Br J Rheum 1996;35:458-62.