Possible interaction of zopiclone and nefazodone

Annals of Pharmacotherapy

Volumn 35, Issue 11, 2001, Pages 1378-1380

  Alderman, C P ^a   Gebauer, M G ^a   Gilbert, A L ^a   Condon, J T ^a  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

Drug interaction; Nefazodone; Zopiclone

Indexed keywords

CYTOCHROME P450 3A4; NEFAZODONE; ZOPICLONE;

AGED; ARTICLE; CASE REPORT; DEPRESSION; DROWSINESS; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG POTENTIATION; DRUG WITHDRAWAL; ENANTIOMER; ENZYME INHIBITION; FEMALE; HUMAN; HYPNOSIS; INSOMNIA; PRIORITY JOURNAL; SEDATION;

EID: 0034754793     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1A074     Document Type: Article

References (19)

1. A receptor function
2. A receptor subtypes
3. Pharmacokinetics of zopiclone and its enantiomers in caucasian young healthy volunteers
4. Enantioselective determination of zopiclone and its metabolites in urine by capillary electrophoresis
5. Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism
6. The effect of erythromycin on the pharmacokinetics and pharmacodynamics of zopiclone
7. Effect of itraconazole on the pharmacokinetics and pharmacodynamics of zopiclone
8. Concentrations and effects of zopiclone are greatly reduced by rifampicin
9. Stereospecific high-performance liquid chromatographic assay of zopiclone in human plasma
10. Clinically significant pharmacokinetic drug interactions with benzodiazepines
11. Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition
12. Pharmacokinetic drug interactions of new antidepressants: A review of the effects on the metabolism of other drugs
13. Identification of the cytochrome P450 enzymes involved in the metabolism of cisapride: In vitro studies of potential co-medication interactions
14. Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: Cytochromes mediating transformation, and P450-3A4 inhibitory actions
15. Inhibition of cytochrome P450 by nefazodone in vitro: Studies of dextromethorphan O- and N-demethylation
16. Preparative and analytical separation of the zopiclone enantiomers and determination of their affinity to the benzodiazepine receptor binding site
17. Role of CYP3A4 in human hepatic diltiazem N-demethylation: Inhibition of CYP3A4 activity by oxidized diltiazem metabolites
18. In vitro screening of human hepatic P450 enzymes by five angiotensin-II receptor antagonists
19. A method for estimating the probability of adverse drug reactions