Anatomical-physiological approaches in pharmacokinetics and pharmacodynamics

Clinical Pharmacokinetics

Volumn 40, Issue 10, 2001, Pages 707-722

  Mather, L E ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; BUPIVACAINE; DRUG; LIDOCAINE; PRILOCAINE;

BLOOD FLOW; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG METABOLISM; PHARMACOKINETICS; PHARMACOLOGY; PRIORITY JOURNAL; REVIEW;

EID: 0034753867     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-200140100-00002     Document Type: Review

References (43)

1. A compartmental analysis of the pharmacokinetics of propofol in sheep
2. A physiological model of induction of anaesthesia with propofol in sheep: 1. Structure and estimation of variables
3. A physiological model of induction of anaesthesia with propofol in sheep: 2. Model analysis and implications for dose requirements
4. Ketamine and midazolam decrease cerebral blood flow and consequently their own rate of transport to the brain: An application of mass balance pharmacokinetics with a changing regional blood flow
5. The effect of thiopental on cerebral blood flow, and its relation to plasma concentration, during simulated induction of anaesthesia in a porcine model
6. Meperidine kinetics in man: Intravenous injection in surgical patients and volunteers
7. Cardiac output is a determinant of the initial concentrations of propofol after short-infusion administration
8. History and developmental aspects of the indicator dilution technic
9. Systemic and regional pharmacokinetics of bupivacaine and levobupivacaine in sheep
10. The use of mass balance principles to describe regional drug distribution and elimination
11. A review of the pharmacokinetics and pharmacodynamics of remifentanil
12. Blood vessel uptake and metabolism of organic nitrates in the rat
13. Influence of sample site on blood concentrations of ICI 35868
14. Kinetics of thiopentone in relation to the site of sampling
15. Pharmacology of local anaesthetic agents: Pharmacokinetics of local anaesthetic agents
16. Predictive accuracy of continuous propofol infusions in neurosurgical patients: Comparison of pharmacokinetic models
17. Disposition of propofol between red blood cells, plasma, brain and cerebrospinal fluid in rabbits
18. Cerebrospinal fluid concentrations of propofol during anaesthesia in humans
19. Steady-state propofol brain: Plasma and brain: Blood partition coefficients and the effect-site equilibration paradox
20. Cardiovascular effects and regional clearances of IV bupivacaine in sheep: Enantiomeric analysis
21. Effects of propofol and of thiopentone anaesthesia on the regional kinetics of pethidine in the sheep
22. A sheep preparation for studying interactions between blood flow and drug disposition. VI: Effects of general or subarachnoid anaesthesia on blood flow and chlormethiazole disposition
23. Uptake and elution of chlormethiazole, meperidine, and minaxolone in the hindquarters of sheep: Implications for clearance calculations
24. The in vitro uptake and metabolism of lignocaine, procainamide and pethidine by tissues of the hindquarters of sheep
25. The uptake and elution of lignocaine and procainamide in the hindquarters of the sheep described using mass balance principles
26. The in vivo blood, fat and muscle concentrations of lignocaine and bupivacaine in the hindquarters of sheep
27. Disposition of morphine and its 3-glucuronide metabolites during morphine infusion in the sheep
28. Comparative disposition of morphine-3-glucuronide during separate intravenous infusions of morphine and morphine-3-glucuronide in sheep: Importance of the kidney
29. Influence of renal failure of the disposition of morphine, morphine-3-glucuronide and morphine-6-glucuronide in sheep
30. Chiral kinetics and dynamics of ketorolac
31. New insights into the site and mode of antinociceptive action of flurbiprofen enantiomers
32. Comparison of the effects of isoflurane or fentanyl-nitrous oxide anaesthesia on propranolol disposition in dogs
33. Effect of i.v. anaesthesia with propofol on drug distribution and metabolism in the dog
34. Plasma concentrations of the stereoisomers of prilocaine after administration of the racemate: Implications for toxicity?
35. Microdialysis study of the blood-brain equilibration of thiopentone enantiomers
36. Electroencephalographic effects of thiopentone enantiomers in the rat: Correlation with drug tissue distribution
37. Electroencephalographic effects of thiopentone and its enantiomers in the rat
38. Intravenous tolerability of large doses of levobupivacaine in sheep
39. Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep
40. Direct cardiac effects of intracoronary levobupivacaine, bupivacaine and ropivacaine in the sheep
41. Properties, absorption and disposition of local anesthetics
42. The legacy of John Snow: An appreciation of his life and scientific contribution on the 100th anniversary of his death