From chromosomal alterations to target genes for therapy: Integrating cytogenetic and functional genomic views of the breast cancer genome

Seminars in Cancer Biology

Volumn 11, Issue 5, 2001, Pages 395-401

  Monni, Outi ^a,b   Hyman, Elizabeth ^a,c   Mousses, Spyro ^a   Barlund, Maarit ^d   Kallioniemi, Anne ^a   Kallioniemi, Olli P ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

Amplification; Breast cancer; cDNA microarray; CGH microarray; Tissue microarray

Indexed keywords

COMPLEMENTARY DNA;

BREAST CANCER; BREAST CARCINOGENESIS; CANCER GROWTH; CHROMOSOME REARRANGEMENT; COMPARATIVE GENOMIC HYBRIDIZATION; CYTOGENETICS; DNA MICROARRAY; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; GENE THERAPY; HUMAN; REVIEW; SOLID TUMOR;

EID: 0034751656     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1006/scbi.2001.0395     Document Type: Article

References (33)

1. The role of chromosome translocations in leukomogenesis
2. Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization
3. Multicolor spectral karyotyping of human chromosomes
4. Use of a cDNA microarray to analyse gene expression patterns in human cancer
5. Chromosome analysis of 97 primary breast carcinomas: Identification of eight karyotypic subgroups
6. Chromosomal imbalance maps of malignant solid tumors: A cytogenetic survey of 3185 neoplasms
7. Spectral karyotyping and chromosome banding studies of primary breast carcinomas and their lymph node metastases
8. Molecular cytogenetic analysis of breast cancer cell lines
9. Chromosomal alterations in 15 breast cancer cell lines by comparative genomic hybridization and spectral karyotyping
10. Comparative genomic hybridization analysis of breast tumors with predetermined profiles of DNA amplification
11. Molecular cytogenetics of primary breast cancer by CGH
12. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
13. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines
14. Positional cloning of ZNF217 and NABC1: Genes amplified at 20q13.2 and overexpressed in breast carcinoma
15. Matrix-based comparative genomic hybridization: Biochips to screen for genomic imbalances
16. High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays
17. Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene
18. Gene expression profiling of primary breast carcinomas using arrays of candidate genes
19. Comparative genomic hybridization analysis of 38 breast cancer cell lines: A basis for interpreting complementary DNA microarray data
20. Linking gene expression patterns to therapeutic groups in breast cancer
21. Molecular portraits of human breast tumors
22. Systematic variation in gene expression patterns in human cancer cell lines
23. In vivo gene expression profile analysis of human breast cancer progression
24. Gene-expression profiles in hereditary breast cancer
25. Genome-wide analysis of DNA copy-number changes using cDNA microarrays
26. Detection of gene amplification by genomic hybridization to cDNA microarrays
27. Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer
28. Detecting activation of ribosomal protein S6 kinase by complementary DNA and tissue microarray analysis
29. Multiple genes at 17q23 undergo amplification and overexpression in breast cancer
30. Tissue microarray for high-throughput molecular profiling of tumor specimens
31. Tissue microarray technology for high-throughput molecular profiling of cancer
32. Validation of tissue microarray technology in breast carcinoma