Heparin-binding epidermal growth factor-like growth factor is an autocrine mediator of human prostate stromal cell growth in vitro

Journal of Urology

Volumn 165, Issue 1, 2001, Pages 284-288

  Duque, Jose Luis ^a,b   Adam, Rosalyn M ^a,b   Mullen, John S ^a,b   Lin, Jianqing ^a,b   Richie, Jerome P ^a,b   Freeman, Michael R ^a,b,c  

^a Children's Hospital   (Canada)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Prostatic hyperplasia; Receptor, epidermal growth factor; Stroma cells

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; DESMIN; HEPARIN BINDING EPIDERMAL GROWTH FACTOR;

APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CELL COMPARTMENTALIZATION; CELL GROWTH; FIBROBLAST; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MEDIATOR RELEASE; PRIORITY JOURNAL; PROSTATE EPITHELIUM; PROSTATE HYPERTROPHY; RECEPTOR AFFINITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STIMULUS RESPONSE; STROMA CELL;

EID: 0034750924     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005392-200101000-00080     Document Type: Article

References (28)

1. Morphometric quantitation of stroma in human benign prostatic hyperplasia
2. Regulation of prostatic growth and function by peptide growth factors
3. Retroviral transduction of transforming growth factor-beta1 induces pleiotropic benign prostatic growth abnormalities in mouse prostate reconstitutions
4. Stromal cells of the human prostate: Initial isolation and characterization
5. Basic FGF, EGF, and PDGF modify TGFβ-induction of smooth muscle cell phenotype in human prostate stromal cells
6. FGF7 and FGF2 are increased in benign prostatic hyperplasia and are associated with increased proliferation
7. Heparin-binding EGF-like growth factor in the human prostate: Synthesis predominantly by interstitial and vascular smooth muscle cells and action as a carcinoma cell mitogen
8. Heparin-binding EGF-like growth factor
9. Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity
10. Amphiregulin is coordinately expressed with heparin-binding epidermal growth factor-like growth factor in the interstitial smooth muscle of the human prostate
11. Epidermal growth factor, epidermal growth factor receptor, and transforming growth factor-α in human hyperplastic prostate tissue: Expression and cellular localization
12. The localization of transforming growth factor alpha and epidermal growth factor in stromal and epithelial compartments of developing human prostate and hyperplastic, dysplastic and carcinomatous lesions
13. The effect of androgen, estrogen and growth factors on the proliferation of cultured fibroblasts derived from human and fetal adult prostates
14. Developmental and hormonal regulation of transforming growth factor-α and epidermal growth factor receptor gene expression in isolated prostatic epithelial and stromal cells
15. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability
16. Stretch activates heparin-binding EGF-like growth factor expression in bladder smooth muscle cells
17. Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: Conversion from juxtacrine to paracrine growth factor activity
18. The membrane protein CD9/DRAP27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor
19. Androgenic regulation of growth factor and growth factor receptor expression in the CWR22 model of prostatic adenocarcinoma
20. Immunohistochemical comparative analysis of transforming growth factor alpha, epidermal growth factor and epidermal growth factor receptor in normal, hyperplastic and neoplastic human prostates
21. Comparative analysis of mRNA and protein expression for epidermal growth factor receptor and ligands relative to the proliferative index in human prostate tissue
22. Targeting the epidermal growth factor receptor for therapy of carcinomas
23. The EGF receptor as central transducer of heterologous signalling systems
24. Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines
25. Functional analysis of four tetraspans, CD9, CD53, CD81, and CD82, suggests a common role in costimulation, cell adhesion and migration: Only CD9 upregulates HB-EGF activity
26. Possible role of coexpression of CD9 with membrane-anchored heparin binding EGF-like growth factor and amphiregulin in human keratinocyte growth
27. Growth factors in expressed prostatic fluid from men with prostate cancer, BPH and clinically normal prostates
28. The role of stromal-epithelial interaction in normal and malignant growth