α2-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator

British Journal of Pharmacology

Volumn 134, Issue 4, 2001, Pages 763-770

  Orito, K ^a   Kishi, M ^a   Imaizumi, T ^a   Nakazawa, T ^a   Hashimoto, A ^a   Mori, T ^a   Kambe, T ^a  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Antagonist; Blood pressure; Mydriasis; OPC 28326; Peripheral vasodilator; Pithed rat; Postsynaptic; Vas deferens; Yohimbine

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BRIMONIDINE; CLONIDINE; OPC 28326; UNCLASSIFIED DRUG; YOHIMBINE; [4 (N METHYL 2 PHENYLETHYLAMINO) 1 (3,5 DIMETHYL 4 PROPIONYLAMINOBENZOYL)]PIPERIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING; ELECTROSTIMULATION; KIDNEY CORTEX; MALE; MYDRIASIS; NONHUMAN; POSTSYNAPTIC MEMBRANE; PRESSOR RESPONSE; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; RAT; TENSION; VAS DEFERENS; VASODILATATION;

EID: 0034748535     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704309     Document Type: Article

References (28)

1. Some quantitative uses of drug antagonists
2. Separation of adrenergic and non-adrenergic contractions to field stimulation in the rat vas deferens
3. 50) of an enzymatic reaction
4. 2C-adrenergic receptors enable cold-induced vasoconstriction in cutaneous arteries
5. Functional evidence for heterogeneity of peripheral prejunctional alpha 2-adrenoceptors
6. Characterization of alpha 2 adrenoceptors and other adrenoceptors in membranes isolated from dog mesenteric nerve axons
7. 2-adrenoceptors
8. Human postjunctional alpha-1 and alpha-2 adrenoceptors: Differential distribution in arteries of the limbs
9. 2-adrenergic responses in cutaneous veins: Role of receptor reserve
10. Influence of yohimbine on blood pressure, autonomic reflexes, and plasma catecholamines in humans
11. 2-adrenoceptor activation increases from the distal to the proximal part of the veins of canine limbs
12. 2-adrenoceptors
13. 2D subtype
14. 2-adrenoceptors
15. 2-adrenoceptor subtypes: Selectivity of various agonists and relative distribution of receptors as determined in rats
16. Isolation of rat genomic clones encoding subtypes of the alpha 2-adrenergic receptor. Identification of a unique receptor subtype
17. 2-adrenergic receptor subtypes b and c
18. 2-adrenoceptor-subtype function
19. The distribution of adrenoceptors and other drug receptors between the two ends of the rat vas deferens as revealed by selective agonists and antagonists
20. 2a-adrenergic receptor subtype
21. Two phases of contractile response in rat isolated vas deferens and their regulation by adenosine and α-receptors
22. 2-autoreceptors in the rabbit pulmonary artery and human saphenous vein
23. Mechanisms of action of OPC-28326, a selective hindlimb vasodilator
24. 2-adrenoceptor subtypes
25. 2D-subtype?
26. 2-adrenergic vasoconstriction during contraction of glycolytic, not oxidative, rat hindlimb muscle
27. 3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors
28. Selectivity of some alpha adrenoceptor agonists for peripheral alpha-1 and alpha-2 adrenoceptors in the normotensive rat