Clinical features of diabetic patients with 0.01-0.1% heteroplasmy A3243G mutation in leukocyte mitochondrial DNA [2]

Diabetes Research and Clinical Practice

Volumn 54, Issue 3, 2001, Pages 215-217

  Iwase, M ^a   Gotoh, D ^a   Urata, M ^a   Kang, D ^a   Hamasaki, N ^a   Yoshinari, M ^a   Fujishima, M ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; GLUTAMATE DECARBOXYLASE; HEMOGLOBIN A1C; INSULIN; LACTIC ACID; MITOCHONDRIAL DNA; SULFONYLUREA;

ADULT; AGED; CHRONIC KIDNEY FAILURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEUROPATHY; DIET THERAPY; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; HEARING LOSS; HUMAN; HYPERGLYCEMIA; INSULIN RELEASE; LACTATE BLOOD LEVEL; LETTER; MAJOR CLINICAL STUDY; MALE; MUSCLE TISSUE; MUSCLE WEAKNESS; MUTATION; ONSET AGE; OXIDATIVE STRESS; PATHOGENESIS; POLYMERASE CHAIN REACTION; SCREENING TEST;

ADULT; AGE FACTORS; AGE OF ONSET; AGED; DIABETES MELLITUS; DNA, MITOCHONDRIAL; FEMALE; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; MUTATION;

EID: 0034748245     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8227(01)00295-9     Document Type: Letter

References (8)

1. Mutation in the mitochondrial tRNA LEU(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness
2. Maternally inherited diabetes and deafness. A new diabetes subtype
3. Clinical relevance of heteroplasmic concentration of mitochondrial A3243G mutation in leucocytes
4. Diabetes and mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS). Radiolabeled polymerase chain reaction is necessary for accurate detection of low percentages of mutation
5. New sensitive method for the detection of the A3243G mutation of human mitochondrial deoxyribonucleic acid in diabetes mellitus patients by ligation-mediated polymerase chain reaction
6. Level of heteroplasmy for the mitochondrial mutation A3243G correlates with age at onset of diabetes and deafness
7. Introduction
8. Human aging is associated with stochastic somatic mutations of mitochondrial DNA