Common variants in the β2-(Gln27Glu) and β3-(Trp64Arg)-adrenoceptor genes are associated with elevated serum NEFA concentrations and Type II diabetes

Diabetologia

Volumn 44, Issue 5, 2001, Pages 629-636

  Carlsson, M ^a   Orho Melander, M ^a   Hedenbro, J ^a   Groop, L C ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Insulin; Lipolysis; Non esterified fatty acids; Type II diabetes; 2 adrenoreceptor; 3 adrenoreceptor

Indexed keywords

ARGININE; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; FATTY ACID; GLUTAMIC ACID; GLUTAMINE; TRYPTOPHAN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; COMORBIDITY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE CONTROL; GENETIC SUSCEPTIBILITY; GENOTYPE; GLUCOSE TOLERANCE; HOMOZYGOSITY; HUMAN; LIPOLYSIS; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; ALLELE; AMINO ACID SUBSTITUTION; BLOOD; BLOOD PRESSURE; CAUCASIAN; CHEMISTRY; COMPARATIVE STUDY; GENETIC VARIABILITY; GENETICS; GLUCOSE BLOOD LEVEL; HOMOZYGOTE; METABOLISM; MIDDLE AGED; NUCLEAR FAMILY; REFERENCE VALUE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SWEDEN;

ALLELES; AMINO ACID SUBSTITUTION; ARGININE; BLOOD GLUCOSE; BLOOD PRESSURE; CHOLESTEROL, HDL; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FATTY ACIDS, NONESTERIFIED; FEMALE; GENOTYPE; GLUTAMIC ACID; GLUTAMINE; HOMOZYGOTE; HUMANS; INSULIN; MALE; MIDDLE AGED; NUCLEAR FAMILY; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, ADRENERGIC, BETA-3; REFERENCE VALUES; SWEDEN; TRIGLYCERIDES; TRYPTOPHAN; VARIATION (GENETICS);

EID: 0034744185     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051670     Document Type: Article

References (53)

1. Non-insulin-dependent diabetes mellitus-a collision between thrifty genes and an affluent society
2. The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects. Results of the Paris prospective study
3. A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM
4. Insulin action and substrate competition
5. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
6. Fat cell adrenergic receptors and the control of white and brown fat cell function
7. Demonstration of an in vivo functional beta 3-adrenoceptor in man
8. Distribution of beta 3-adrenoceptor mRNA in human tissues
9. Targeted disruption of the beta 3-adrenergic receptor gene
10. Determination of beta 3-adrenoceptor mediated lipolysis in human fat cells
11. Implications of genetic variability of human beta2-adrenergic receptor structure
12. Amino-terminal polymorphisms of the human beta2-adrenergic receptor impart distinct agonist-promoted regulatory properties
13. Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta 2 adrenoceptor function
14. The different effects of a Gln27Glu beta 2-adrenoceptor gene polymorphism on obesity in males and in females
15. The Gln27Glu beta2-adrenergic receptor variant is associated with obesity due to subcutaneous fat accumulation in Japanese men
16. Association of polymorphisms in the beta2-adrenergic receptor gene with obesity, hypertriglyceridaemia, and diabetes mellitus
17. Polymorphism in the 5′-leader cistron of the beta2-adrenergic receptor gene associated with obesity and Type II diabetes
18. Lack of association between a human beta-2 adrenoceptor gene polymorphism (gln27glu) and morbid obesity
19. Gln27Glu variant of the human beta2-adrenoreceptor gene is not associated with early-onset obesity in Danish men
20. Polymorphisms of the 5′leader cistron of the human beta 2-adrenergic receptor regulate receptor expression
21. Genetic variation in the b3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity
22. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the b3-adrenergic-receptor gene
23. Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns
24. Meta-analysis of the association of Trp64Arg polymorphism of beta 3-adrenergic receptor gene with body mass index
25. A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans
26. Association of the Trp64Arg mutation of the beta3-adrenergic receptor with fatty liver and mild glucose intolerance in Japanese subjects
27. A quantitative trait locus influencing BMI maps to the region of the beta-3 adrenergic receptor
28. The Trp64Arg mutation of the beta3 adrenergic receptor gene has no effect on obesity phenotypes in the Quebec Family Study and Swedish Obese Subjects cohorts
29. Meta-analysis of the association of the Trp64Arg polymorphism in the beta3 adrenergic receptor with body mass index
30. The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not associated with obesity or Type II diabetes mellitus in a large population-based Caucasian cohort
31. Beta3-adrenergic receptor Trp64Arg polymorphism does not predict incident CHD or carotid intima-media thickness in a community-based sample of whites: The ARIC study. Atherosclerosis Risk in Communities
32. Genetic polymorphism and disease
33. Genetic dissection of complex traits
34. Loci on chromosomes 2 (NIDDM 1) and 15 interact to increase susceptibility to diabetes in Mexican Americans
35. Additive effect of A®G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity
36. Additive effects of the mutations in the beta3-adrenergic receptor and uncoupling protein-1 genes on weight loss and weight maintenance in Finnish women
37. cDNA for the human beta 2-adrenergic receptor: A protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor
38. The permutation test for paired replicates. The case of one sample, two measures or paired replicates
39. A paired-sibling analysis of the XbaI polymorphism in the muscle glycogen synthase gene
40. Trp64Arg mutation of beta3-adrenoceptor gene deteriorates lipolysis induced by beta3-adrenoceptor agonist in human omental adipocytes
41. The biochemical effect of the naturally occurring Trp64 → Arg mutation on human beta3-adrenoceptor activity
42. Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function
43. Nocturnal regulation of free fatty acids in healthy young and elderly men
44. Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM
45. Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance
46. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
47. Modulation of hepatic glucose production by non-esterified fatty acids in Type II (non-insulin-dependent) diabetes mellitus
48. Relationship of body fat distribution to the metabolic clearance of insulin in premenopausal women
49. The glucose fatty-acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
50. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
51. Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans
52. Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes
53. Lack of association between the Trp64Arg mutation in the beta 3-adrenergic receptor gene and obesity in Japanese men: A longitudinal analysis