Protein binding of 99tcm-dtpa compared with other gfr tracers

Nuclear Medicine Communications

Volumn 22, Issue 6, 2001, Pages 617-623

  Rehling, M ^a   Nielsen, L E ^a   Marqversen, J ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

125I iothalamate; 51Cr EDTA; 99mTc DTPA; Protein binding; Renal clearance

Indexed keywords

DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; EDETIC ACID; PENTETATE TECHNETIUM TC 99M; PLASMA PROTEIN; RADIOPHARMACEUTICAL AGENT; EDETATE CHROMIUM CR 51; IOTALAMIC ACID I 125;

ALGORITHM; ARTICLE; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; GLOMERULUS FILTRATION RATE; KIDNEY; METABOLISM; PROTEIN BINDING; SCINTISCANNING; THIN LAYER CHROMATOGRAPHY; ULTRAFILTRATION; ADULT; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; HUMAN; HUMAN EXPERIMENT; ISOTOPE LABELING; KIDNEY CLEARANCE;

ALGORITHMS; BLOOD PROTEINS; CHROMATOGRAPHY, THIN LAYER; EDETIC ACID; GLOMERULAR FILTRATION RATE; INDICATORS AND REAGENTS; KIDNEY; PROTEIN BINDING; RADIOPHARMACEUTICALS; TECHNETIUM TC 99M PENTETATE; ULTRAFILTRATION;

EID: 0034743838     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/00006231-200106000-00003     Document Type: Review

References (22)

1. Carlsen JE, Møller ML, Lund JO, Trap-Jensen J. Comparison of four commercial Tc-99m(Sn)DTPA preparations used for the measurement of glomerular filtration rate. J Nucl Med 1980; 21: 126-129.
2. Klopper JF, Hauser W, Atkins HL, Eckelman WC, Richards P. Evaluation of 99mTc-DTPA for the measurement of glomerular filtration rate. J Nucl Med 1972; 13: 107-110.
3. Russell CD, Bischoff PG, Rowell KL, et al. Quality control of Tc-99m DTPA for measurement of glomerular filtration: concise communication. J Nucl Med 1983; 24: 722-727.
4. Russell CD, Rowell K, Scott JW. Quality control of technetium-99m DTPA: correlation of analytic tests with in vivo protein binding in man. J Nucl Med 1986; 27: 560-562.
5. Jeghers O, Piepsz A, Ham HR. What does protein binding of radiopharmaceuticals mean exactly? Eur J Nucl Med 1990; 17: 101-102.
6. Blaufox MD, Aurell M, Bubeck B, et al. Report of the Radionuclides in Nephrourology Committee on renal clearance. J Nucl Med 1996; 37: 1883-1890.
7. Rehling M, Nielsen BV, Pedersen EB, Nielsen LE, Hansen HE, Bacher T. Renal and extrarenal clearance of 99mTc-MAG3: a comparison with 125I-OIH and 51Cr-EDTA in patients representing all levels of glomerular filtration rate. Eur J Nucl Med 1995; 22: 1379-1384.
8. Hays MT, Green FA. in vitro studies of 99mTc-pertechnetate binding by human serum and tissues. J Nucl Med 1973; 14: 149-158.
9. Fogh-Andersen N. Binding of the chromium-ethylenediaminetetraacetic acid complex (Cr-EDTA) to human albumin. Scand J Clin Lab Invest 1980; 40: 805-808.
10. Russell CD, Crittenden RC, Cash AG. Determination of net ionic charge on Tc-99m DTPA and Tc-99m EDTA by a column ion-exchange method. J Nucl Med 1980; 21: 354-360.
11. Russell CD, Bischoff PG, Rowell KL, Lloyd LK, Dubovsky EV. Estimation of extracellular fluid volume from plasma clearance on technetium-99m DTPA by a single-injection, two-sample method. J Nucl Med 1988; 29: 255-258.
12. Budavari, S (ed). The Merck Index, 12th edn. Whitehouse Station, NJ: Merck Research Laboratories, 1996: monograph no. 5080, p. 868.
13. Hauser W, Atkins HL, Nelson KG, Richards P. Technetium-99m DTPA: a new radiopharmaceutical for brain and kidney scanning. Radiology 1970; 94: 679-684.
14. Hosain F. Quality control of 99mTc-DTPA by double-tracer clearance technique. J Nucl Med 1974; 15: 442-445.
15. Moore M, Rhodes BA. Is the radiochemical purity of Tc-99m radiopharmaceuticals decreasing? J Nucl Med 1982; 23: 548-549.
16. Rehling M, Møller ML, Thamdrup B, Lund JO, Trap-Jensen J. Simultaneous measurement of renal clearance and plasma clearance of 99mTc-labelled diethylenetriaminepentaacetate, 51Cr-labelled ethylenediaminetetraacetate and inulin in man. Clin Sci 1984; 66: 613-619.
17. Rehling M. Stability, protein binding and clearance studies of 99mTc-DTPA. Evaluation of a commercially available dry-kit. Scand J Clin Lab Invest 1988; 48: 603-609.
18. Fleming JS, Wilkinson J, Oliver RM, Ackery DM, Blake GM, Waller DG. Comparison of radionuclide estimation of glomerular filtration rate using technetium 99m diethylenetriaminepentaacetic acid and chromium 51 ethylenediaminetetraacetic acid. Eur J Nucl Med 1991; 18: 391-395.
19. Biggi A, Viglietti A, Farinelli MC, Bonada C, Camuzzini G. Estimation of glomerular filtration rate using chromium-51 ethylenediaminetetraacetic acid and technetium-99m diethylenetriaminepentaacetic acid. Eur J Nucl Med 1995; 22: 532-536.
20. Galli G, Rufini V, Meduri G, Piraccini R, D’Andrea G. Determination of glomerular filtration rate with 99mTc-DTPA in clinical practice. J Nucl Biol Med 1994; 38: 556-565.
21. Brøchner-Mortensen J. Routine methods and their reliability for assessment of glomerular filtration rate in adults, with special reference to total 51Cr-EDTA plasma clearance. Dan Med Bull 1978; 25: 181-202.
22. Smith HW. The physiology of the kidney. London: Oxford University Press, 1937.