A multiethnic study of Δ32ccr5 and ccr2b-V64I allele distribution in four Los Angeles populations

Diagnostic Molecular Pathology

Volumn 10, Issue 2, 2001, Pages 105-110

  Iyer, Ramaswamy K ^a   Kim, Phillip S ^a   Bando, Joanne M ^a   Lu, Kan V ^a   Gregg, Jeffrey P ^b   Grody, Wayne W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chemokine receptors; Disease progression; Ethnic stratification; Founder effect; HIV AIDS

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR5; DNA; MONOCYTE CHEMOATTRACTANT PROTEIN 1 RECEPTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; COHORT ANALYSIS; DISEASE PREDISPOSITION; DNA SEQUENCE; ETHNIC GROUP; GENE FREQUENCY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE SYSTEM; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRUS INFECTION; ALLELE; AMERICAN INDIAN; ASIAN AMERICAN; GENETICS; HISPANIC; MUTATION; NEGRO;

AFRICAN CONTINENTAL ANCESTRY GROUP; ALLELES; ASIAN AMERICANS; DNA; ETHNIC GROUPS; GENE FREQUENCY; HISPANIC AMERICANS; HUMANS; INDIANS, NORTH AMERICAN; MUTATION; POLYMERASE CHAIN REACTION; RECEPTORS, CCR5; RECEPTORS, CHEMOKINE;

EID: 0034743799     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-200106000-00006     Document Type: Article

References (27)

1. The extent of genetic variation in the CCR5 gene
2. HIV-1 infection in an individual homozygous for the CCR5 deletion allele
3. HIV entry and its inhibition
4. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
5. Specific cell surface requirements for the infection of CD4-positive cells by human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus
6. + T cells
7. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene
8. Identification of a major coreceptor for primary isolates of HIV-1
9. A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
10. + cells is mediated by the chemokine receptor CC-CKR5
11. Host factors and the pathogenesis of HIV-induced disease
12. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
13. Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection
14. A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation
15. Influence of the CCR2-V64I polymorphism on human immunodeficiency virus type l coreceptor activity and on chemokine receptor function of CCR2b, CCR3, CCR5, and CXCR4
16. Chemokine receptors: Keys to AIDS pathogenesis?
17. Homozygous defect in HIV-1 co-receptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
18. The genetic structure of admixed populations
19. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
20. Global distribution of the CCR5 gene 32-basepair deletion
21. Host genes and HIV: The role of the chemokine receptor gene CCR5 and its allele (Δ32ccr5)
22. The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression
23. The role of CCR5 and CCR2 polymorphisms in HIV-1 transmission and disease progression
24. Evolutionary relationships of human populations on a global scale
25. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual encounters
26. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression
27. Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material