C α methylation in molecular recognition: Application to substance P and the two neurokinin-1 receptor binding sites

European Journal of Biochemistry

Volumn 268, Issue 10, 2001, Pages 2997-3005

  Sagan, Sandrine ^b,c   Lequin, Olivier ^b   Frank, Fabrice ^b   Convert, Odile ^b   Ayoub, Mimoun ^a,b   Lavielle, Solange ^b   Chassaing, Gérard ^b  

^a Senn Chemicals AG   (Switzerland)

^b SORBONNE UNIVERSITÉ   (France)

^c Laboratoire de Chimie Organique Biologique   (France)

Author keywords

Binding sites; C methylation; Conformational analysis; Molecular recognition; Tachykinins

Indexed keywords

2 AMINO 2 METHYLPROPIONIC ACID; ADENYLATE CYCLASE; CYCLIC AMP; INOSITOL PHOSPHATE; NEUROKININ 1 RECEPTOR; PHOSPHOLIPASE C; SUBSTANCE P; SUBSTANCE P DERIVATIVE; DRUG DERIVATIVE; LIGAND; METHANOL; PEPTIDE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHO CELL; CIRCULAR DICHROISM; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; METHYLATION; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING; SECOND MESSENGER; ANIMAL; BINDING COMPETITION; CELL MEMBRANE; CHEMISTRY; DOSE RESPONSE; HAMSTER; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

ANIMALIA;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CELL MEMBRANE; CHO CELLS; CIRCULAR DICHROISM; CRICETINAE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; INOSITOL PHOSPHATES; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; METHANOL; METHYLATION; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NEUROKININ-1; SUBSTANCE P;

EID: 0034741390     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.02192.x     Document Type: Article

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