Evidence for transcortical reflex pathways in the lower limb of man

Progress in Neurobiology

Volumn 62, Issue 3, 2000, Pages 251-272

  Christensen, L O D ^a   Petersen, N ^a   Andersen, J B ^b   Sinkjaer T ^b   Nielsen, J B ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b AALBORG UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

FACILITATION; GAIT; HUMAN; LEG; LEG MUSCLE; MOTOR CORTEX; MUSCLE SPINDLE AFFERENT NERVE; MUSCLE STRETCHING; MYOTATIC REFLEX; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL TRACT; REFLEX; REVIEW; SKIN; SKIN STIMULATION; SOLEUS MUSCLE;

ANIMALS; GAIT; HUMANS; LEG; MOTOR CORTEX; MUSCLE, SKELETAL; NEURAL PATHWAYS; REFLEX; SOMATOSENSORY CORTEX;

EID: 0034739737     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-0082(00)00007-1     Document Type: Review

References (118)

1. Adrian E.D., Moruzzi G. Impulses in the pyramidal tract. J. Physiol. 97:1939;153-199.
2. Aniss A.M., Gandevia S.C., Burke D. Reflex responses in active muscles elicited by stimulation of low-threshold afferents from the human foot. J. Neurophysiol. 67:(5):1992;1375-1384.
3. Armstrong D.M. The supraspinal control of mammalian locomotion. J. Physiol. (Lond.). 405:1988;1-37.
4. Armstrong D.M., Drew T. Locomotor-related neuronal discharges in cat motor cortex compared with peripheral receptive fields and evoked movements. J. Physiol. (Lond.). 346:1984;497-517.
5. Asanuma H., Arissian K. Experiments on functional role of peripheral input to motor cortex during voluntary movements in the monkey. J. Neurophysiol. 52:(2):1984;212-227.
6. Baker M.A., Tyner C.F., Towe A.L. Observations on single neurons recorded in the sigmoid gyri of awake, non-paralysed cats. Exp. Neurol. 32:1971;388-403.
7. Berardelli A., Sabra A.F., Hallett M., Berenberg W., Simon S.R. Stretch reflexes of triceps surae in patients with upper motor neuron syndromes. J. Neurol. Neurosurg. Psychiatry. 46:(1):1983;54-60.
8. Brooks V.B., Rudomon P., Slayman C.L. Sensory activation of neurons in the cat's cerebral cortex. J. Neurophysiol. 24:1961;286-301.
9. Brooks V.B., Rudomon P., Slayman C.L. Peripheral receptive fields of neurons in the cat's cerebral cortex. J. Neurophysiol. 24:1961;302-325.
10. Brouwer B., Ashby P. Corticospinal projections to lower limb motoneurons in man. Exp. Brain Res. 89:(3):1992;649-654.
11. Burke D., Dickson H.G., Skuse N.F. Task-dependent changes in the responses to low-threshold cutaneous afferent volleys in the human lower limb. J. Physiol. (Lond.). 432:1991;445-458.
12. Burke D., Hicks R., Gandevia S.C., Stephen J., Woodforth I., Crawford M. Direct comparison of corticospinal volleys in human subjects to transcranial magnetic and electrical stimulation. J. Physiol. (Lond.). 470:1993;383-393.
13. Capaday C., Forget R., Fraser R., Lamarre Y. Evidence for a contribution of the motor cortex to the long-latency stretch reflex of the human thumb. J. Physiol. (Lond.). 440:1991;243-255.
14. Chan C.W. Segmental versus suprasegmental contributions to long-latency stretch responses in man. Adv. Neurol. 39:1983;467-487.
15. Chan C.W., Kearney R.E., Melvill-Jones G. Tibialis anterior response to sudden ankle displacements in normal and Parkinsonian subjects. Brain Res. 173:(2):1979;303-314.
16. Cheney P.D., Fetz E.E. Corticomotoneuronal cells contribute to long-latency stretch reflexes in the rhesus monkey. J. Physiol. (Lond.). 349:1984;249-272.
17. Choa B.H., Stephens J.A. Cutaneous reflex responses and central nervous lesions studied in the lower limb in man. J. Physiol. 328:1982;23-24P.
18. Chofflon M., Lachat J.M., Ruegg D.G. A transcortical loop demonstrated by stimulation of low-threshold muscle afferents in the awake monkey. J. Physiol. (Lond.). 323:1982;393-402.
19. Christensen L.O., Morita H., Petersen N., Nielsen J. Evidence suggesting that a transcortical reflex pathway contributes to cutaneous reflexes in the tibialis anterior muscle during walking in man. Exp. Brain Res. 124:1999;59-68.
20. Corna S., Grasso M., Nardone A., Schieppati M. Selective depression of medium-latency leg and foot muscle responses to stretch by an alpha 2-agonist in humans. J. Physiol. (Lond.). 484:(Part 3):1995;803-809.
21. Cowan J.M., Day B.L., Marsden C., Rothwell J.C. The effect of percutaneous motor cortex stimulation on H reflexes in muscles of the arm and leg in intact man. J. Physiol. (Lond.). 377:1986;333-347.
22. Day B.L., Riescher H., Struppler A., Rothwell J.C., Marsden C.D. Changes in the response to magnetic and electrical stimulation of the motor cortex following muscle stretch in man. J. Physiol. (Lond.). 433:1991;41-57.
23. Deuschl G., Ludolph A., Schenck E., Lucking C.H. The relations between long-latency reflexes in hand muscles, somatosensory evoked potentials and transcranial stimulation of motor tracts. Electroencephalogr. Clin. Neurophysiol. 74:(6):1989;425-430.
24. Deuschl G., Michels R., Berardelli A., Schenck E., Inghilleri M., Lucking C.H. Effects of electric and magnetic transcranial stimulation on long latency reflexes. Exp. Brain Res. 83:(2):1991;403-410.
25. Diener H.C., Ackermann H., Dichgans J., Guschlbauer B. Medium- and long-latency responses to displacements of the ankle joint in patients with spinal and central lesions. Electroencephalogr. Clin. Neurophysiol. 60:(5):1985;407-416.
26. Diener H.C., Dichgans J., Hulser P.J., Buettner U.W., Bacher M., Guschlbauer B. The significance of delayed long-loop responses to ankle displacement for the diagnosis of multiple sclerosis. Electroencephalogr. Clin. Neurophysiol. 57:(4):1984;336-342.
27. Duysens J., Tax A.A., Murrer L., Dietz V. Backward and forward walking use different patterns of phase-dependent modulation of cutaneous reflexes in humans. J. Neurophysiol. 76:(1):1996;301-310.
28. Duysens J., Tax A.A., Nawijn S., Berger W., Prokop T., Altenmuller E. Gating of sensation and evoked potentials following foot stimulation during human gait. Exp. Brain Res. 105:(3):1995;423-431.
29. Duysens J., Tax A.A., Trippel M., Dietz V. Phase-dependent reversal of reflexly induced movements during human gait. Exp. Brain Res. 90:(2):1992;404-414.
30. Duysens J., Tax A.A., Trippel M., Dietz V. Increased amplitude of cutaneous reflexes during human running as compared to standing. Brain Res. 613:(2):1993;230-238.
31. Duysens J., Trippel M., Horstmann G.A., Dietz V. Gating and reversal of reflexes in ankle muscles during human walking. Exp. Brain Res. 82:(2):1990;351-358.
32. Edgley S.A., Eyre J.A., Lemon R.N., Miller S. Excitation of the corticospinal tract by electromagnetic and electrical stimulation of the scalp in the macaque monkey. J. Physiol. (Lond.). 425:1990;301-320.
33. Edgley S.A., Eyre J.A., Lemon R.N., Miller S. Comparison of activation of corticospinal neurons and spinal motor neurons by magnetic and electrical transcranial stimulation in the lumbosacral cord of the anaesthetized monkey. Brain. 120:(Part 5):1997;839-853.
34. Evarts E.V. Motor cortex reflexes associated with learned movement. Science. 179:(72):1973;501-503.
35. Farmer S.F., Halliday D.M., Conway B.A., Stephens J.A., Rosenberg J.R. A review of recent applications of cross-correlation methodologies to human motor unit recording. J. Neurosci. Methods. 74:(2):1997;175-187.
36. Fellows S.J., Domges F., Topper R., Thilmann A.F., Noth J. Changes in the short- and long-latency stretch reflex components of the triceps surae muscle during ischaemia in man. J. Physiol. (Lond.). 472:1993;737-748.
37. Fellows S.J., Topper R., Schwarz M., Thilmann A.F., Noth J. Stretch reflexes of the proximal arm in a patient with mirror movements: absence of bilateral long-latency components. Electroencephalogr. Clin. Neurophysiol. 101:(2):1996;79-83.
38. Fetz E.E., Finocchio D.V., Baker M.A., Soso M.J. Sensory and motor responses of precentral cortex cells during comparable passive and active joint movements. J. Neurophysiol. 43:(4):1980;1070-1089.
39. Fetz E.E., Gustafsson B. Relation between shapes of post-synaptic potentials and changes in firing probability of cat motoneurones. J. Physiol. (Lond.). 341:1983;387-410.
40. Forssberg H., Grillner S., Rossignol S. Phasic gain control of reflexes from the dorsum of the paw during spinal locomotion. Brain Res. 132:(1):1977;121-139.
41. Ghez C., Shinoda Y. Spinal mechanisms of the functional stretch reflex. Exp. Brain Res. 32:(1):1978;55-68.
42. Hagbarth K.E., Hagglund J.V., Wallin E.U., Young R.R. Grouped spindle and electromyographic responses to abrupt wrist extension movements in man. J. Physiol. (Lond.). 312:1981;81-96.
43. Hammond P.H. Involuntary activity in biceps following sudden application of velocity to the abducted forearm. J. Physiol. (Lond.). 127:1954;23P-25P.
44. Hammond P.H. The influences of prior instruction to the subject on an apparently involuntary neuro-muscular response. J. Physiol. (Lond.). 132:1956;17P-18P.
45. Hepp-Reymond M.-C. Functional organization of motor cortex and its participation in voluntary movements. Seklis H.D., Erwin J. Comparative Primate Biology. vol. 4:1988;501-624 Liss, New York.
46. Herman D., Kang R., MacGillis M., Zarzecki P. Responses of cat motor cortex neurons to cortico-cortical and somatosensory inputs. Exp. Brain Res. 57:(3):1985;598-604.
47. Hess C.W., Mills K.R., Murray N.M.F. Responses in small hand muscles from magnetic stimulation of the human brain. J.Physiol. (Lond.). 388:1987;397-419.
48. Hore J., Preston J.B., Cheney P.D. Responses of cortical neurons (areas 3a and 4) to ramp stretch of hindlimb muscles in the baboon. J. Neurophysiol. 39:(3):1976;484-500.
49. Iles J.F., Cummings R. Electrical and magnetic stimulation of motor cortex in man. J. Physiol. (Lond.). 446:1992;223P.
50. Iles J.F., Pisini J.V. Cortical modulation of transmission in spinal reflex pathways of man. J. Physiol. (Lond.). 455:1992;425-446.
51. Issler H., Stephens J.A. The maturation of cutaneous reflexes studied in the upper limb in man. J. Physiol. (Lond.). 335:1983;643-654.
52. Jankowska E., Padel Y., Tanaka R. Disynaptic inhibition of spinal motoneurones from the motor cortex in the monkey. J. Physiol. (Lond.). 258:(2):1976;467-487.
53. Johannsen, P., Christensen, L.O., Sinkjær, T., Nielsen, J.B., in press. Cerebral functional anatomy of voluntary contractions of ankle muscles in man. J. Physiol.
54. Kearney R.E., Chan C.W. Contrasts between the reflex responses to tibialis anterior and triceps surae to sudden ankle rotation in normal human subjects. Electroencephalogr. Clin. Neurophysiol. 54:(3):1982;301-310.
55. Kernell D., Chien-Ping W.U. Responses of the pyramidal tract to stimulation of the baboon's motor cortex. J. Physiol. (Lond.). 191:(3):1967;653-672.
56. Lee R.G., Murphy J.T., Tatton W.G. Long-latency myotatic reflexes in man: mechanisms, functional significance, and changes in patients with Parkinson's disease or hemiplegia. Adv. Neurol. 39:1983;489-508.
57. Lemon R.N. Short-latency peripheral inputs to the motor cortex in conscious monkeys. Brain Res. 161:(1):1979;150-155.
58. Lemon R.N. Functional properties of monkey motor cortex neurones receiving afferent input from the hand and fingers. J. Physiol. (Lond.). 311:1981;497-519.
59. Lemon R.N., Porter R. A comparison of the responsiveness to peripheral stimuli of pre-central cortical neurones in anaesthetized and conscious monkeys [proceedings]. J. Physiol. (Lond.). 260:(2):1976;53P-54P.
60. Lemon R.N., Porter R. Afferent input to movement-related precentral neurones in conscious monkeys. Proc. R. Soc. Lond. B, Biol. Sci. 194:(1116):1976;313-339.
61. Lundberg A. Control of spinal mechanisms from the brain. Tower D.B. The Nervous System. 1975;253-265 Raven, New York.
62. Marple-Horvat D.E., Amos A.J., Armstrong D.M., Criado J.M. Changes in the discharge patterns of cat motor cortex neurones during unexpected perturbations of on-going locomotion. J. Physiol. (Lond.). 462:1993;87-113.
63. Marple-Horvat D.E., Armstrong D.M. Central regulation of motor cortex neuronal responses to forelimb nerve inputs during precision walking in the cat. J. Physiol. (Lond.). 519:(Pt1):1999;279-299.
64. Marsden C.D., Merton P.A., Morton H.B. Latency measurements compatible with a cortical pathway for the stretch reflex in man. J. Physiol. (Lond.). 230:(1):1973;58P-59P.
65. Marsden C.D., Merton P.A., Morton H.B., Adam J. The effect of lesions of the sensorimotor cortex and the capsular pathways on servo responses from the human long thumb flexor. Brain. 100:(3):1977;503-526.
66. Marsden C.D., Merton P.A., Morton H.B., Adam J. The effect of posterior column lesions on servo responses from the human long thumb flexor. Brain. 100:(Part 1):1997;185-200.
67. Marsden C.D., Rothwell J.C., Day B.L. Long-latency automatic responses to muscle stretch in man: origin and function. Adv. Neurol. 39:1983;509-539.
68. Matthews P.B. Evidence from the use of vibration that the human long-latency stretch reflex depends upon spindle secondary afferents. J. Physiol. (Lond.). 348:1984;383-415.
69. Matthews P.B. Analysis of human long-latency reflexes by cooling the peripheral conduction pathway: which afferents are involved? Prog. Brain Res. 80:1989;103-112.
70. Matthews P.B., Farmer S.F., Ingram D.A. On the localization of the stretch reflex of intrinsic hand muscles in a patient with mirror movements. J. Physiol. (Lond.). 428:1990;561-577.
71. Melvill-Jones G., Watt D.G. Observations on the control of stepping and hopping movements in man. J. Physiol. (Lond.). 219:(3):1971;709-727.
72. Miller A.D., Brooks V.B. Late muscular responses to arm perturbations persist during supraspinal dysfunctions in monkeys. Exp. Brain Res. 41:(2):1981;146-158.
73. Morita H., Petersen N., Christensen L.O., Sinkjær T., Nielsen J. Sensitivity of H-reflexes and stretch reflexes to presynaptic inhibition in humans. J. Neurophysiol. 80:(2):1998;610-620.
74. Mortimer J.A., Webster D.D. Evidence for a quantitative association between EMG stretch responses and Parkinsonian rigidity. Brain Res. 162:(1):1979;169-173.
75. Muller K., Homberg V. Development of speed of repetitive movements in children is determined by structural changes in corticospinal efferents. Neurosci. Lett. 144:(12):1992;57-60.
76. Muller K., Homberg V., Lenard H.G. Magnetic stimulation of motor cortex and nerve roots in children. Maturation of cortico-motoneuronal projections. Electroencephalogr. Clin. Neurophysiol. 81:(1):1991;63-70.
77. Nardone A., Grasso M., Giordano A., Schieppati M. Different effect of height on latency of leg and foot short- and medium-latency EMG responses to perturbation of stance in humans. Neurosci. Lett. 206:(2-3):1996;89-92.
78. Nardone A., Schieppati M. Medium-latency response to muscle stretch in human lower limb: estimation of conduction velocity of group II fibres and central delay. Neurosci. Lett. 249:(1):1988;29-32.
79. Nielsen J., Kagamihara Y. Differential projection of the sural nerve to early and late recruited tibialis anterior motor units: change of the recruitment gain. Acta Physiologica. Scandinavica. 147:1993;385-401.
80. Nielsen J., Kagamihara Y. Synchronization of human leg motor units during co-contraction in man. Exp. Brain Res. 102:(1):1994;84-94.
81. Nielsen J., Morita H., Baumgarten J., Petersen N., Christensen L.O. On the comparability of H-reflexes and MEPs. Electroencephalogr. Clin. Neurophysiol. Suppl. 51:1999;93-101.
82. Nielsen J., Petersen N. Is presynaptic inhibition distributed to corticospinal fibres in man? J. Physiol. (Lond.). 477:(Part 1):1994;47-58.
83. Nielsen J., Petersen N., Ballegaard M. Latency of effects evoked by electrical and magnetic brain stimulation in lower limb motoneurones in man. J. Physiol. (Lond.). 484:1995;791-802.
84. Nielsen J., Petersen N., Deuschl G., Ballegaard M. Task-related changes in the effect of magnetic brain stimulation on spinal neurones in man. J. Physiol. (Lond.). 471:1993;223-243.
85. Nielsen J., Petersen N., Fedirchuk B. Evidence suggesting a transcortical pathway from cutaneous foot afferents to tibialis anterior motoneurones in man. J. Physiol. (Lond.). 501:(Part 2):1997;473-484.
86. Palmer E., Ashby P. The transcortical nature of the late reflex responses in human small hand muscle to digital nerve stimulation. Exp. Brain Res. 91:(2):1992;320-326.
87. Palmer E., Ashby P. Evidence that a long latency stretch reflex in humans is transcortical. J. Physiol. (Lond.). 449:1992;429-440.
88. Palmer E., Ashby P. Corticospinal projections to upper limb motoneurones in humans. J. Physiol. (Lond.). 448:1992;397-412.
89. Palmer C.I., Marks W.B., Bak M.J. The responses of cat motor cortical units to electrical cutaneous stimulation during locomotion and during lifting, falling and landing. Exp. Brain Res. 58:(1):1985;102-116.
90. Petersen N., Christensen L.O., Morita H., Sinkjær T., Nielsen J. Evidence that a transcortical pathway contributes to stretch reflexes in the tibialis anterior muscle in man. J. Physiol. (Lond.). 512:(Part 1):1998;267-276.
91. Phillips C.G. Motor apparatus of the baboon's hand. Proc. R. Soc. Lond. (Biol.). 173:1969;141-173.
92. Phillips C.G., Porter R. Corticospinal neurones. Their role in movement. Monogr. Physiol. Soc. 34:V-XII:1977;1-450.
93. Picard N., Smith A.M. Primary motor cortical responses to perturbations of prehension in the monkey. J. Neurophysiol. 68:(5):1992;1882-1894.
94. Pijnappels M., Van Wezel B.M., Colombo G., Dietz V., Duysens J. Cortical facilitation of cutaneous reflexes in leg muscles during human gait. Brain Res. 787:(1):1998;149-153.
95. Priori A., Bertolasi L., Dressler D., Rothwell J.C., Day B.L., Thompson P.D., Marsden C.D. Transcranial electric and magnetic stimulation of the leg area of the human motor cortex: single motor unit and surface EMG responses in the tibialis anterior muscle. Electroencephalogr. Clin. Neurophysiol. 89:(2):1993;131-137.
96. Prochazka, A., Clarac, F., Loeb, G.E., Rothwell, J.C., Wolpaw, J.R., 2000. What do reflex and voluntary mean? Modern views on an ancient debate. Exp. Brain Res. 130 (4), 417-432.
97. Rothwell J.C. Techniques and mechanisms of action of transcranial stimulation of the human motor cortex. J. Neurosci. Methods. 74:(2):1997;113-122.
98. Rowlandson P.H., Stephens J.A. Maturation of cutaneous reflex responses recorded in the lower limb in man. Dev. Med. Child Neurol. 27:(4):1985;425-433.
99. Rudomin P., Nunez R., Madrid J. Modulation of synaptic effectiveness of Ia and descending fibers in cat spinal cord. J. Neurophysiol. 38:(5):1975;1181-1195.
100. Schieppati M., Nardone A. Medium-latency stretch reflexes of foot and leg muscles analysed by cooling the lower limb in standing humans. J. Physiol. (Lond.). 503:(Part 3):1997;691-698.
101. Schieppati M., Nardone A., Siliotto R., Grasso M. Early and late stretch responses of human foot muscles induced by perturbation of stance. Exp. Brain Res. 105:(3):1995;411-422.
102. Sinkjær T., Andersen J.B., Nielsen J.F., Hansen H.J. Soleus long-latency stretch reflexes during walking in healthy and spastic humans. Electroencephalogr. Clin. Neurophysiol. 110:(5):1999;951-959.
103. Stewart D.H., Preston J.B. Functional coupling between the pyramidal tract and segmental motoneurons in cat and primate. J. Neurophysiol. 30:(3):1967;453-465.
104. Strick P.L., Preston J.B. Sorting of somatosensory afferent information in primate motor cortex. Brain Res. 156:(2):1978;364-368.
105. Tanji J., Wise S.P. Submodality distribution in sensorimotor cortex of the unanesthetized monkey. J. Neurophysiol. 45:(3):1981;467-481.
106. Tatton W.G., Forner S.D., Gerstein G.L., Chambers W.W., Liu C.N. The effect of postcentral cortical lesions on motor responses to sudden upper limb displacements in monkeys. Brain Res. 96:(1):1975;108-113.
107. Tatton W.G., Lee R.G. Evidence for abnormal long-loop reflexes in rigid Parkinsonian patients. Brain Res. 100:(3):1975;671-676.
108. Thilmann A.F., Schwarz M., Topper R., Fellows S.J., Noth J. Different mechanisms underlie the long-latency stretch reflex response of active human muscle at different joints. J. Physiol. (Lond.). 444:1991;631-643.
109. Toft E., Sinkjær T., Andreassen S. Mechanical and electromyographic responses to stretch of the human anterior tibial muscle at different levels of contraction. Exp. Brain Res. 74:(1):1989;213-219.
110. Toft E., Sinkjær T., Andreassen S., Larsen K. Mechanical and electromyographic responses to stretch of the human ankle extensors. J. Neurophysiol. 65:(6):1991;1402-1410.
111. Towe A.L., Patton H.D., Kennedy T.T. Response properties of neurons in the precruciate cortex of the cat following electrical stimulation of the appendages. Exp. Neurol. 10:1964;325-344.
112. Tracey D.J., Walmsley B., Brinkman J. 'Long-loop' reflexes can be obtained in spinal monkeys. Neurosci. Lett. 18:(1):1980;59-65.
113. Wannier T.M., Toltl M., Hepp-Reymond M.C. Neuronal activity in the postcentral cortex related to force regulation during a precision grip task. Brain Res. 382:(2):1986;427-432.
114. Yang J.F., Stein R.B. Phase-dependent reflex reversal in human leg muscles during walking. J. Neurophysiol. 63:(5):1990;1109-1117.
115. Zehr E.P., Fujita K., Stein R.B. Reflexes from the superficial peroneal nerve during walking in stroke subjects. J. Neurophysiol. 79:(2):1998;848-858.
116. Zehr E.P., Fujita K., Stein R.B. Reflexes from the superficial peroneal nerve during walking in stroke subjects. J. Neurophysiol. 79:(2):1998;848-858.
117. Zehr E.P., Stein R.B. What functions do reflexes serve during human locomotion? Prog. Neurobiol. 58:(2):1999;185-205.
118. Zehr E.P., Komiyama T., Stein R.B. Cutaneous reflexes during human gait: electromyographic and kinematic responses to electrical stimulation. J. Neurophysiol. 77:(6):1997;3311-3325.