Stopped-flow spectrophotometric analysis of intermediates in the peroxo-dependent inactivation of cytochrome P450 by aldehydes

Journal of Inorganic Biochemistry

Volumn 81, Issue 3, 2000, Pages 153-160

  Raner, Gregory M ^a   Hatchell, Andrew J ^a   Morton, Patrick E ^a   Ballou, David P ^b   Coon, Minor J ^b  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Aldehydes; Cytochrome P450; Heme; Isoporphyrin; Kinetics

Indexed keywords

3 PHENYLBUTYRALDEHYDE; 3 PHENYLPROPIONALDEHYDE; ALDEHYDE; CYTOCHROME P450; GLYCINE; HEME; HYDROGEN PEROXIDE; ISOENZYME; ISOPORPHYRIN; PHENYLALANINE; PORPHYRIN DERIVATIVE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ABSORPTION SPECTROPHOTOMETRY; AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; ENZYME INACTIVATION; REACTION ANALYSIS; STOP FLOW TECHNIQUE; TECHNIQUE;

ALDEHYDES; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; HEME; HYDROGEN PEROXIDE; KINETICS; MODELS, CHEMICAL; OXYGEN; PORPHYRINS; PROTEIN BINDING; PROTEIN ISOFORMS; SPECTROPHOTOMETRY; TIME FACTORS;

EID: 0034739010     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-0134(00)00098-2     Document Type: Article

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