Analysis of the nucleotide binding sites of mitochondrial ATP synthase provides evidence for a two-site catalytic mechanism

Biochimica et Biophysica Acta - Bioenergetics

Volumn 1458, Issue 2-3, 2000, Pages 234-251

  Berden, J A ^a   Hartog, A F ^a  

^a BioCentrum   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; NUCLEOTIDE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; ENERGY METABOLISM; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; MITOCHONDRION; PRIORITY JOURNAL; REVIEW; SYNTHESIS;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING SITES; MITOCHONDRIA, HEART; NUCLEOTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTON-TRANSLOCATING ATPASES; PROTONS;

EID: 0034737931     PISSN: 00052728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2728(00)00076-1     Document Type: Review

References (96)

1. Y Kagawa N Sone M Yoshida H Hirata H Okamoto Proton translocating ATPase of a thermophilic bacterium J. Biochem. 80 1976 141 151
2. R.D Todd T.A Griesenbeck M.G Douglas The yeast mitochondrial adenosine triphosphatase complex J. Biol. Chem. 255 1980 5461 5467
3. 1-ATPase isolated from Saccharomyces carlsbergensis Biochim. Biophys. Acta 634 1981 271 278
4. J.V Moroney L Loprestio B.F McEwen R.E McCarthy G.C Hommes The Mr-value of chloroplast coupling factor 1 FEBS Lett. 158 1983 58 63
5. 1) determined by photolabelling with 8-azido-ATP and 8-azido-ADP Biochim. Biophys. Acta 593 1980 204 211
6. A.E Senior J.G Wise The proton-ATPase of bacteria and mitochondria J. Membr. Biol. 73 1983 105 124
7. 32P]diphosphate Biochemistry 24 1985 7372 7379
8. 1-ATPase Eur. J. Biochem. 148 1985 41 47
9. G Girault G Berger J.-M Galmiche F Andre Characterization of six nucleotide-binding sites on chloroplast coupling factor 1 and one site on its purified beta subunit J. Biol. Chem. 263 1988 14690 14695
10. R.J Wagenvoord I van der Kraan A Kemp Specific photolabelling of beef heart mitochondrial ATPase by 8-azido-ATP Biochim. Biophys. Acta 460 1977 17 24
11. 1-ATPase Eur. J. Biochem. 143 1984 483 490
12. D Bar-Zvi M.A Tiefert N Shavit Interaction of the chloroplast ATP synthase with the photoreactive nucleotide 3′-O-(4-benzoyl)benzoyl adenosine 5′-diphosphate FEBS Lett. 160 1983 233 238
13. 1-ATPase: Photoaffinity labeling of β-subunit Tyr-368 at a noncatalytic site and β Tyr-345 at a catalytic site Proc. Natl. Acad. Sci. USA 84 1987 5715 5719
14. 1-ATPase from bovine heart mitochondria Nature 370 1994 621 628
15. C Grubmeyer H.S Penefsky The presence of two hydrolytic sites on beef heart mitochondrial adenosine triphosphatase J. Biol. Chem. 256 1981 3718 3727
16. C Grubmeyer H.S Penefsky Cooperativity between catalytic sites in the mechanism of action of beef heart mitochondrial adenosine triphosphatase J. Biol. Chem. 256 1981 3728 3734
17. J.E Walker M Saraste M.J Runswick N.J Gay Distantly related sequences in the α and β subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold EMBO J. 1 1982 945 951
18. P.D Boyer The binding change mechanism for ATP synthase: Some probabilities and possibilities Biochim. Biophys. Acta 1140 1993 215 250
19. P.D Boyer R.L Cross W Momsen A new concept for energy coupling in oxidative phosphorylation based on a molecular explanation of the oxygen exchange reaction Proc. Natl. Acad. Sci. USA 70 1973 2837 2839
20. E.C. Slater, J. Rosing, D.A. Harris, R.J. van der Stadt, A. Kemp, The identification of functional ATPase in energy-transducing membranes, in: G.F. Azzone, M.E. Klingenberg, E. Quagliariello, N. Siliprandi (Eds.), Membrane Proteins in Transport and Phosphorylation, North-Holland, Amsterdam, 1974, pp. 137–147.
21. 1 Biochim. Biophys. Acta 893 1987 22 32
22. 1-adenosine triphosphatase of Escherichia coli with chemical ligands and the asymmetry of β subunits Biochim. Biophys. Acta 1015 1990 216 222
23. 1-ATPase as a function of the interaction of α-β subunit pairs with the γ and the ε subunits J. Biol. Chem. 270 1995 20568 20574
24. 1-ATPase mutant βTyr-297-Cys: functional studies and asymmetry of the enzyme under various nucleotide conditions based on reaction of the introduced Cys with N-ethylmaleimide and 7-chloro-4-nitrobenzofurazan Biochim. Biophys. Acta 1276 1996 154 160
25. A.F Knowles H.S Penefsky The subunit structure of beef heart mitochondrial adenosine triphosphatase J. Biol. Chem. 247 1972 6617 6623
26. i by beef heart mitochondrial adenosine triphosphatase J. Biol. Chem. 252 1977 2891 2899
27. N.E Garrett H.S Penefsky Interaction of adenine nucleotides with multiple binding sites on beef heart mitochondrial adenosine triphosphatase J. Biol. Chem. 250 1975 6640 6647
28. J Rosing D.A Harris E.C Slater A Kemp The possible role of tightly bound adenine nucleotide in oxidative and photosynthetic phosphorylation J. Supramol. Struct. 3 1975 284 296
29. 1-ATPase J. Biol. Chem. 261 1986 12544 12549
30. 1: characterisation of high-affinity binding sites Biochim. Biophys. Acta 850 1986 359 368
31. 1-ATPase activity by binding of (2-azido-)ADP to a slowly exchangeable non-catalytic nucleotide binding site Biochim. Biophys. Acta 1101 1992 329 338
32. 3ADP as probe. Effects of the modification on ATPase and ITPase activity Biochim. Biophys. Acta 1229 1995 103 114
33. 1-ATPase J. Biol. Chem. 262 1987 11675 11683
34. 1-ATPase J. Biol. Chem. 263 1988 14053 14060
35. 1-adenosine triphosphatase Biochim. Biophys. Acta 548 1979 63 71
36. 1-ATPase Biochem. Biophys. Res. Commun. 100 1981 1032 1038
37. 1-ATPase is due to saturation of noncatalytic sites with ADP which blocks activation of the enzyme by ATP J. Biol. Chem. 269 1994 319 325
38. 32P]adenosine diphosphate J. Biol. Chem. 262 1987 15172 15181
39. 1-ATPase and inhibits catalysis is bound at a catalytic site Biochim. Biophys. Acta 1020 1990 43 48
40. R.E Ebel H.A Lardy Stimulation of rat liver mitochondrial adenosinetriphosphatase by anions J. Biol. Chem. 250 1975 191 196
41. D Recktenwald B Hess Allosteric influence of anions on mitochondrial ATPase of yeast FEBS Lett. 76 1977 25 28
42. E Stutterheim M.A.C Henneke J.A Berden Studies on the structure and conformation of yeast mitochondrial ATPase using aurovertin and methanol as probes Biochim. Biophys. Acta 592 1980 415 430
43. +-ATP synthase from various species Biochem. Biophys. Res. Commun. 201 1994 487 492
44. D.A Harris J Rosing R.J van der Stadt E.C Slater Tight binding of adenine nucleotides to beef-heart mitochondrial ATPase Biochim. Biophys. Acta 314 1973 149 153
45. +-ATPase aus Chloroplasten, PhD Thesis, Biologisches Institut der Universität Stuttgart, 1995.
46. S Beharry P.D Bragg The bound adenine nucleotides of purified bovine mitochondrial ATP synthase Eur. J. Biochem. 240 1996 165 172
47. 1 by FSBA: sites of binding and effect on activity Biochim. Biophys. Acta 1318 1997 123 132
48. 1 specifically and can be bound together with AXP at the same α-subunit Biochim. Biophys. Acta 1318 1997 107 122
49. 1-ATPase by 5′- p -fluorosulfonylbenzoyladenosine J. Biol. Chem. 261 1986 5722 5730
50. 1-ATPase J. Biol. Chem. 262 1987 3488 3495
51. C Grubmeyer R.L Cross H.S Penefsky Mechanism of ATP hydrolysis by beef heart mitochondrial ATPase J. Biol. Chem. 257 1982 12092 12100
52. 1-ATPase turnover during ATP hydrolysis by the single catalytic site FEBS Lett. 212 1987 63 67
53. 1 can be described only on the basis of a dual-site mechanism Biochim. Biophys. Acta 1057 1991 151 156
54. 1-ATPase J. Biol. Chem. 257 1982 2874 2881
55. 1-ATPase which is involved in the negative cooperativity of ATP hydrolysis Biochim. Biophys. Acta 1142 1993 327 335
56. R.L Cross C Grubmeyer H.S Penefsky Mechanism of ATP hydrolysis by beef heart mitochondrial ATPase J. Biol. Chem. 257 1982 12101 12105
57. E.C Slater J.A Berden M.B.M van Dongen The mechanism of action of mitochondrial ATPase (ATP Synthase) J. Protein Chem. 5 1986 177 192
58. 3H]8-azido-ADP Biochim. Biophys. Acta 850 1986 121 130
59. 1-ATPase J. Biol. Chem. 268 1993 1558 1566
60. 1-ATPase with trinitrophenyl derivatives of ATP and ADP J. Biol. Chem. 269 1994 15431 15439
61. A.E Senior The proton-translocating ATPase of Escherichia coli Annu. Rev. Biophys. Biophys. Chem. 19 1990 7 41
62. 1-ATPase provides a direct probe of nucleotide binding: Maximal ATP hydrolysis occurs with three sites occupied J. Biol. Chem. 268 1993 20126 20133
63. 32P]ADP: Modification of the catalytic site 2 (loose) and the catalytic site 3 (open) impairs multi-site, but not uni-site catalysis of both ATP synthesis and ATP hydrolysis Biochim. Biophys. Acta 1456 2000 77 98
64. A Matsuno-Yagi Y Hatefi Studies on the mechanism of oxidative phosphorylation J. Biol. Chem. 268 1993 1539 1545
65. 0-ATP synthase, PhD Thesis, University of Amsterdam, 1996.
66. J.J Czarnecki Tautomerism of 2-azidoadenine nucleotides. Effects on enzyme kinetics and photoaffinity labeling Biochim. Biophys. Acta 800 1984 41 51
67. J.J Czarnecki M.S Abbott B.R Selman Photoaffinity labeling with 2-azidoadenosine diphosphate of a tight nucleotide binding site on chloroplast coupling factor 1 Proc. Natl. Acad. Sci. USA 79 1982 7744 7748
68. 1-ATPase Biochemistry 25 1986 4431 4437
69. 1 revealed by dissociation and reconstitution with 2-azido-ATP Biochim. Biophys. Acta 1100 1992 267 277
70. 14C]benzofurazan J. Biol. Chem. 259 1984 8219 8225
71. 1-ATPase with 8-Azido-ATP J. Biol. Chem. 258 1983 9307 9313
72. 1-ATPase is inactivated with 5′- p -fluorosulfonylbenzoylethenoadenosine J. Biol. Chem. 265 1990 8065 8074
73. 3H]ADP entrapped as fluorometal complexes into the catalytic sites of the enzyme Biochemistry 33 1994 3772 3777
74. 1-ATPase covalently inhibited with 4-chloro-7-nitrobenzofurazan: the structure provides further support for a rotary catalytic mechanism Structure 6 1998 831 837
75. S.J Ferguson W.J Lloyd G.K Radda The mitochondrial ATPase. Selective modification of a nitrogen residue in the beta subunit Eur. J. Biochem. 54 1975 127 133
76. 3-ADP FEBS Lett. 347 1994 13 16
77. 1 J. Biol. Chem. 266 1991 10368 10376
78. 1-ATPase is bound at a β-subunit: evidence for a non-rotatory two-site catalytic mechanism Biochim. Biophys. Acta 1412 1999 79 93
79. 1 adenosine 5′-triphosphate Biochemistry 19 1980 5671 5678
80. 1 adenosinetriphosphatase Biochemistry 23 1984 6350 6354
81. 1-adenosinetriphosphatase J. Biol. Chem. 260 1985 1374 1377
82. 1 Biochim. Biophys. Acta 894 1987 277 283
83. 1-ATPase complexes containing one impaired β-subunit are ATPase-active J. Biochem. 106 1989 679 683
84. 1-ATPase with 1, 2, or 3 incompetent catalytic sites J. Biol. Chem. 271 1996 18128 18133
85. 1-ATPase J. Biol. Chem. 263 1988 19640 19648
86. 1-ATPase which is reversed on bond cleavage Biochemistry 33 1994 14275 14280
87. 1 FEBS Lett. 259 1989 33 36
88. +-ATPase aus Chloroplasten: Die kinetik der mit einem protonentransport gekoppelten ATP-synthese auf einem bindungsplatz, PhD Thesis, Physikalische und Angewandte Chemie der Technischen Universität Berlin, 1991.
89. 1-ATPase revisited by the use of HPLC methods J. Bioenerg. Biomembr. 30 1998 543 553
90. H.S Penefsky Rate of chase-promoted hydrolysis of ATP in the high affinity catalytic site of beef heart mitochondrial ATPase J. Biol. Chem. 263 1988 6020 6022
91. T.M Duncan A.E Senior The defective proton-ATPase of uncD mutants of Escherichia coli . Two mutations which affect the catalytic mechanism J. Biol. Chem. 260 1985 4901 4907
92. +-ATPase resulted in loss of multi-site ATPase activity J. Biol. Chem. 261 1986 9196 9201
93. 1-ATPase in Escherichia coli J. Biol. Chem. 269 1994 19232 19237
94. 1-ATPase caused by the γ subunit generates a high affinity nucleotide binding site J. Biol. Chem. 271 1996 2433 2438
95. 1-ATPase from thermophilic bacterium PS3 is accelerated by the chase-addition of excess ATP J. Biol. Chem. 267 1992 4551 4556
96. 1-ATPase Nature 386 1997 299 302