Insect population control using a dominant, repressible, lethal genetic system

Science

Volumn 287, Issue 5462, 2000, Pages 2474-2476

  Thomas, Dean D ^a   Donnelly, Christl A ^a   Wood, Roger J ^b   Alphey, Luke S ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; TRANSCRIPTION FACTOR;

GENETICS; INSECT; PEST CONTROL; STERILITY;

ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; FEMALE; GENE EXPRESSION; GENE REPRESSION; GENETIC ANALYSIS; INSECT CONTROL; LETHAL GENE; MALE; MATHEMATICAL MODEL; NONHUMAN; POPULATION DYNAMICS; PRIORITY JOURNAL; PROGENY; PROMOTER REGION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CROSSES, GENETIC; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EGG PROTEINS; ENHANCER ELEMENTS (GENETICS); FAT BODY; FEMALE; GENE EXPRESSION REGULATION; GENES, DOMINANT; GENES, INSECT; GENES, LETHAL; GENES, RAS; HOMOZYGOTE; MALE; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; PEST CONTROL, BIOLOGICAL; PROMOTER REGIONS (GENETICS); TETRACYCLINE; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

ARACHNIDA; DROSOPHILA MELANOGASTER; HEXAPODA; INSECTA; MELANOGASTER;

EID: 0034737752     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.287.5462.2474     Document Type: Article

References (24)

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23. This model facilitates the comparison of SIT and various RIDL regimes under a set of simple assumptions, based on the original models of Knipling (1). We assume that the pest population is expanding as a new outbreak or recovering from a pesticide program. We have not included stochastic variation, density-dependent factors, life-cycle mortality, or other factors that will vary from one insect species to another. These additional considerations have been discussed elsewhere, for example, (22). With these assumptions, our model provides the basis of a fair comparison of SIT and RIDL, but it cannot be used to predict population reduction for SIT or RIDL applied to a particular insect population.
24. We thank B. Bello for the Hsp26-tTa and tRe-LacZ fly lines, M. Bownes for the Yp3 expression construct pFBE, D. Rogers for critical reading of the manuscript, and P. Burns for technical assistance. This work was funded by UK Medical Research Council (MRC) grant G117/255 to L.S.A. D.D.T. is a UK Biotechnology and Biological Sciences Research Council DPhil student, C.A.D. is supported by the Wellcome Trust, and L.S.A. is a MRC Senior Research Fellow.