New strategy for the design of ligands for the purification of pharmaceutical proteins by affinity chromatography

Journal of Chromatography B: Biomedical Sciences and Applications

Volumn 740, Issue 1, 2000, Pages 17-33

  Sproule, Kenny ^a   Morrill, Paul ^a   Pearson, James C ^b   Burton, Steven J ^b   Hejnæs, Kim R ^c   Valore, Henrik ^c   Ludvigsen, Svend ^c   Lowe, Christopher R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ProMetic Life Sciences Inc   (Canada)

^c NOVO NORDISK A S   (Denmark)

Author keywords

Chemical combinatorial library; Insulin; Ligands; Proteins

Indexed keywords

INSULIN DERIVATIVE; RECOMBINANT PROTEIN;

AFFINITY CHROMATOGRAPHY; ARTICLE; COMPUTER ANALYSIS; DRUG DESIGN; DRUG SYNTHESIS; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN PURIFICATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION; TECHNIQUE; THEORY;

AMINO ACID SEQUENCE; BINDING SITES; CHROMATOGRAPHY, AFFINITY; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROINSULIN; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; TRIAZINES;

EID: 0034737563     PISSN: 13872273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(99)00570-8     Document Type: Article

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