Dual modulation of excitatory synaptic transmission by agonists at group I metabotropic glutamate receptors in the rat spinal dorsal horn

Brain Research

Volumn 887, Issue 2, 2000, Pages 359-377

  Zhong, Jie ^c   Gerber, Gabor ^a   Koji, Ljubomir ^b   Randi, Mirjana ^c  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c IOWA STATE UNIVERSITY   (United States)

Author keywords

Excitatory postsynaptic potential; Group I metabotropic glutamate receptors; Slice intracellular recording technique; Spinal cord dorsal horn

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 2 CHLORO 5 HYDROXYPHENYLGLYCINE; 2 METHYL 6 (2 PHENYLVINYL)PYRIDINE; 3,5 DIHYDROXYPHENYLGLYCINE; 4 AMINOBUTYRIC ACID RECEPTOR; 4 CARBOXYPHENYLGLYCINE; CYCLOTHIAZIDE; GLYCINE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; INTRACELLULAR RECORDING; LONG TERM POTENTIATION; MALE; MEMBRANE DEPOLARIZATION; NERVE CELL; NERVE CELL PLASTICITY; NONHUMAN; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; SUBSTANTIA GELATINOSA; SYNAPTIC INHIBITION; SYNAPTIC TRANSMISSION;

ANIMALS; BENZOATES; BICUCULLINE; CYCLOLEUCINE; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; FEMALE; GLYCINE; KINETICS; MAGNESIUM; MALE; METHOXYHYDROXYPHENYLGLYCOL; NERVE FIBERS; PHENYLACETATES; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; SPINAL CORD; STRYCHNINE; SUBSTANTIA GELATINOSA; SYNAPTIC TRANSMISSION;

EID: 0034731599     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)03066-3     Document Type: Article

References (108)

1. Metabotropic glutamate receptors: Electrophysiological properties and role in plasticity
2. Synaptic activation of NMDA receptors drives action potential firing in the superficial dorsal horn of the rat during early postnatal development
3. Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors
4. Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system
5. Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn
6. A synaptic model of memory: Long-term potentiation in the hippocampus
7. Postsynaptic induction and presynaptic expression of hippocampal long-term depression
8. Pharmacology of metabotropic glutamate receptor-mediated enhancement of responses to excitatory and inhibitory amino acids on rat spinal neurones in vivo
9. A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation
10. Metabotropic glutamate receptor activation contributes to nociceptive reflex activity in the rat spinal cord in vitro
11. Enhanced expression of metabotropic glutamate receptor 3 messenger RNA in the rat spinal cord during ultraviolet irradiation induced peripheral inflammation
12. Modulation of AMPA and NMDA responses in rat spinal dorsal horn neurons bytrans-1-aminocyclopentane-1,3-dicarboxylic acid
13. Modulatory effects of NMDA on phosphoinositide responses evoked by the metabotropic glutamate receptor agonist 1S,3R-ACPD in neonatal rat cerebral cortex
14. Potassium conductances in hippocampal neurons blocked by excitatory amino acid transmitters
15. Actions of agonists of metabotropic glutamate receptors on synaptic transmission and transmitter release in the olfactory cortex
16. Pharmacology and functions of metabotropic glutamate receptors A
17. 2+-activated non-specific cationic current in CA1 hippocampal neurons
18. Excitatory effects of ACPD receptor activation in the hippocampus are mediated by direct effects on pyramidal cells and blockade of synaptic inhibition
19. Metabotropic glutamate receptor induced disinhibition is mediated by reduced transmission at excitatory synapses onto interneurons and inhibitory synapses onto pyramidal cells
20. (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5 but not mGlu1 receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus
21. The dorsal horn: State-dependent sensory processing, plasticity and the generation of pain
22. Activity-dependent neuronal plasticity following tissue injury and inflammation
23. Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-α-methyl-4-carboxyphenylglycine
24. The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception
25. Comparison of nociceptive effects produced by intrathecal administration of mGluR agonists
26. Hyperalgesia and allodynia induced by intrathecal (RS)-dihydroxyphenylglycine in rats
27. (RS)-S-DHPG-induced nociception depends on the release of glutamate from primary afferent C-fibers
28. In vivo antinociceptive activity of anti-rat mGluR1 and mGluR5 antibodies in rats
29. An antisense oligonucleotide targeting mGluR1 attenuates allodynia/hyperalgesia in a model of chronic inflammation in rats
30. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP): A potent, selective and systemically active mGlu5 receptor antagonist
31. Excitatory amino acid-mediated components of synaptically-evoked input from dorsal roots to deep dorsal horn neurons in the rat spinal cord slice
32. Spinal dorsal horn synaptic plasticity: Involvement of group I metabotropic glutamate receptors
33. Group II and group III metabotropic glutamate receptor agonists depress synaptic transmission in the rat spinal cord dorsal horn
34. Metabotropic glutamate receptors mediate excitatory transmission in the nucleus of the solitary tract
35. Activation of metabotropic glutamate receptors produces reciprocal regulation of ionotropic glutamate and GABA responses in the nucleus of the tractus solitarius of the rat
36. Potentiation of excitatory postsynaptic potentials by a metabotropic glutamate receptor agonist (1S,3R-ACPD) in frog spinal motoneurons
37. Reduction of resting K current by metabotropic glutamate and muscarinic receptors in rat CA3 cells: Mediation by G-proteins
38. Activation of a nonselective cationic conductance by metabotropic glutamatergic and muscarinic agonists in CA3 pyramidal neurons of the rat hippocampus
39. NMDA receptor dependence of mGlu-mediated depression of synaptic transmission in the CA1 region of the rat hippocampus
40. Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation
41. Rapid desensitization of the metabotropic glutamate receptor that facilitates glutamate release in rat cerebrocortical nerve terminals
42. 2+ sensitivities
43. A novel metabotropic glutamate receptor agonist: Marked depression of monosynaptic excitation in the newborn rat isolated spinal cord
44. Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones
45. Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord
46. Metabotropic glutamate receptors in superficial laminae of the rat dorsal horn
47. Corelease of two fast neurotransmitters at a central synapse
48. Interactions between metabotropic and ionotropic glutamate receptor agonists in the rat spinal cord in vivo
49. Outflow of endogenous aspartate and glutamate from the rat spinal dorsal horn in vitro by activation of low- and high-threshold primary afferent fibers. Modulation by μ-opioids
50. Dual action of metabotropic glutamate receptor agonists on neuronal excitability and synaptic transmission in spinal ventral horn neurons in vitro
51. Modulation of excitatory synaptic responses in rat spinal dorsal horn neurons by (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid
52. Activation of pharmacologically distinct metabotropic glutamate receptors depresses reticulospinal-evoked monosynaptic EPSPs in the lamprey spinal cord
53. Long-term depression of synaptic transmission in the cerebellum: Cellular and molecular mechanisms revisited
54. Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: An electron microscopic study in the rat
55. Long-term synaptic depression in the mammalian brain
56. Characterization of long-term potentiation of C-fiber-evoked potentials in spinal dorsal horn of adult rat: Essential role of NK1 and NK2 receptors
57. Activation of spinal N-methyl-D-aspartate or neurokinin receptors induces long-term potentiation of spinal C-fibre-evoked potentials
58. Evidence for presynaptic N-methyl-d-aspartate autoreceptors in the spinal cord dorsal horn
59. Synaptic plasticity in the hippocampus: LTP and LTD
60. Synaptic depression induced by pharmacological activation of metabotropic glutamate receptors in the perirhinal cortex
61. Acute mechanical hyperalgesia is produced by coactivation of AMPA and metabotropic glutamate receptors
62. The induction of pain: An integrative review
63. Excitatory amino acids (EAAs) stimulate phosphatidylinositol turnover in adult rat striatal slices: Interaction between NMDA and EAA metabotropic receptors
64. Modulation of regenerative membrane properties by stimulation of metabotropic glutamate receptors in rat deep dorsal horn neurons
65. Nociceptive integration in the rat spinal cord: Role of non-linear membrane properties of deep dorsal horn neurons
66. Ionic basis for plateau potentials in deep dorsal horn neurons of the rat spinal cord
67. Tachykinins modulate multiple ionic conductances in voltage-clamped rat spinal dorsal horn neurons
68. Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells
69. Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons
70. Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in the primary afferent neurons: An immunohistochemical study in the rat
71. Two distinct forms of long-term depression coexist in CA1 hippocampal pyramidal cells
72. Metabotropic glutamate receptor-induced homosynaptic long-term depression and depotentiation in the dentate gyrus of the rat hippocampus in vitro
73. Metabotropic glutamate receptor mediated long-term depression in developing hippocampus
74. The effect of trans-ACPD, a metabotropic excitatory amino acid receptor agonist, on the responses of primate spinothalamic tract neurons
75. The group I mGlu receptor agonist S-DHPG induces a novel form of LTD in the CA1 region of the hippocampus
76. Reorganization of the primary afferent termination in the rat spinal dorsal horn during post-natal development
77. Astrocyte-neuron signaling
78. A model of hippocampal memory encoding and retrieval: GABA-ergic control of synaptic plasticity
79. The metabotropic glutamate receptors: Structures and functions
80. Evidence for presynaptic depression of monosynaptic excitation in neonatal rat motoneurones by (1S,3S)- and (1S,3R)-ACPD
81. G protein-coupled receptors mediate a fast excitatory postsynaptic current in CA3 pyramidal neurons in hippocampal slices
82. Plasticity of excitatory synaptic transmission in the spinal cord dorsal horn
83. Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cord
84. Involvement of group I and II mGluRs in spinal dorsal horn synaptic function following tissue or nerve injury
85. Modulation of plateau properties in dorsal horn neurones in a slice preparation of the turtle spinal cord
86. Synaptic mechanisms of hyperalgesia
87. Low-frequency stimulation of afferent Aδ fibers induces long-term depression at primary afferent synapses with substantia gelatinosa neurons in the rat
88. 3,5-Dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus
89. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat
90. Activation of metabotropic glutamate receptors inhibits calcium currents and GABA-mediated synaptic potentials in striatal neurons
91. Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4
92. Metabotropic glutamate receptor mRNA expression in rat spinal cord
93. mGluR5 metabotropic glutamate receptor distribution in rat and human spinal cord: A developmental study
94. Cellular and subcellular localization of the mGluR5a metabotropic glutamate receptor in the rat spinal cord
95. 2+-activated non-specific cationic channels by phospholipase C-linked glutamate receptors in synaptoneurosomes?
96. 2+ concentration elicited by group I metabotropic glutamate receptors activation in the rat spinal dorsal horn
97. Electrophysiological properties of subpopulations of rat dorsal root ganglion neurons in vitro
98. Tetrodotoxin-resistant sodium channels
99. Amino acid-mediated EPSPs at primary afferent synapses with substantia gelatinosa neurones in the rat spinal cord
100. Primary afferent-evoked glycine- and GABA-mediated IPSPs in substantia gelatinosa neurones in the rat spinal cord in vitro
101. Evidence for a role of metabotropic glutamate receptors in sustained nociceptive inputs to rat dorsal horn neurons
102. The involvement of metabotropic glutamate receptors and their intracellular signalling pathways in sustained nociceptive transmission in rat dorsal horn neurons
103. Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord
104. Antisense ablation of type I metabotropic glutamate receptor, mGluR1, inhibits spinal nociceptive transmission
105. Metabotropic glutamate receptors are required for the induction of long-term potentiation
106. Pharmacologically distinct, pertussis toxin-resistant inward currents evoked by metabotropic glutamate receptor (mGluR) agonists in dorsolateral septal nucleus (DLSN) neurons
107. Involvement of group I metabotropic glutamate receptors in LTP and LTD in the spinal dorsal horn of normal and carrageenan-treated rats