Identification of mouse YB1/p50 as a component of the FMRP-associated mRNP particle

Biochemical and Biophysical Research Communications

Volumn 279, Issue 3, 2000, Pages 904-908

  Ceman, Stephanie ^a   Nelson, Retecher ^a   Warren, Stephen T ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

FMR1; FMRP; Fragile X syndrome; MRNP; p50; YB1

Indexed keywords

PROTEIN FMRP; PROTEIN P50; RIBONUCLEOPROTEIN; RNA BINDING PROTEIN; UNCLASSIFIED DRUG; Y BOX BINDING PROTEIN;

ANIMAL CELL; ARTICLE; FRAGILE X SYNDROME; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; TRANSLATION REGULATION;

EID: 0034731497     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.4035     Document Type: Article

References (38)

1. Advances in molecular analysis of fragile X syndrome
2. FMR1 protein: Conserved RNP family domains and selective RNA binding
3. The protein product of the fragile X gene, FMR1, has characteristics of an RNA binding protein
4. Purified recombinant Fmrp exhibits selective RNA binding as an intrinsic property of the fragile X mental retardation protein
5. FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association
6. The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals
7. Oligomerization properties of fragile-X mental-retardation protein (FMRP) and the fragile-X-related proteins FXRIP and FXR2P
8. FXR1, an autosomal homolog of the fragile X mental retardation gene
9. The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2
10. Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex
11. Specific sequences in the Fragile X Syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them
12. A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein
13. Purification and characterization of the major 50-kDa repressor protein from cytoplasmic mRNP of rabbit reticulocytes
14. The major protein of messenger ribonucleoprotein particles in somatic cells is a member of the Y-box binding transcription factor family
15. Isolation and characterization of a cDNA clone for the CCAAT transcription factor EFIA reveals a novel structural motif
16. Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box
17. Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology
18. Role of cytoplasmic mRNP proteins in translation
19. Thermal chromatography of eukaryotic messenger ribonucleoprotein particles on oligo (dT)-cellulose. Evidence for common mRNA-associated proteins invarious cell types
20. Masking of mRNA by Y-box proteins
21. Activities of cold-shock domain proteins in translation control
22. Gene regulation by Y-box proteins: Coupling control of transcription and translation
23. The Y-box factors: A family of nucleic acid binding proteins conserved from Escherichia coli to man
24. Structural and functional properties of the evolutionarily ancient Y-box family of nucleic acid binding proteins
25. A superfamily of proteins that contain the cold-shock domain
26. Xenopus Y-box transcription factors: Molecular cloning, functional analysis, and developmental regulation
27. Sequence analysis of cytoplasmic mRNA-binding proteins of Xenopus oocytes identifies a family of RNA-binding proteins
28. mRNP4, a major mRNA-binding protein from Xenopus oocytes is identical to transcription factor FRGY2
29. Proteins homologous to the Xenopus germ cell-specific RNA-binding proteins p54/p56 are temporally expressed in mouse male germ cells
30. Translational active mRNPs from rabbit reticulocytes are qualitatively different from free mRNA in their translatability in cell-free system
31. Cytoplasmic mRNP proteins affect mRNA translation
32. General RNA binding proteins render translation cap dependent
33. Overexpression in COS cells of p50, the major core protein associated with mRNA, results in translation inhibition
34. The major core protein of messenger ribonucleoprotein particles (p50) promotes initiation of protein biosynthesis in vitro
35. Translational inhibition by the Fragile X mental retardation protein
36. Interaction of the universal mRNA-binding protein, p50, with actin: A possible link between mRNA and microfilaments