A new and practical synthesis of vinyl dichlorides via a non-Wittig-type approach

Tetrahedron Letters

Volumn 41, Issue 21, 2000, Pages 4007-4009

  Wang, Zhe ^a   Campagna, Silvio ^a   Xu, Guoyou ^a   Pierce, Michael E ^a   Fortunak, Joseph M ^a   Confalone, Pat N ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EFAVIRENZ; VINYL CHLORIDE;

ARTICLE; CHEMICAL BINDING; CHEMICAL REACTION KINETICS; DRUG MANUFACTURE; DRUG SYNTHESIS; ECONOMIC ASPECT; REACTION ANALYSIS; STRUCTURE ANALYSIS;

EID: 0034729185     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00547-5     Document Type: Article

References (13)

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2. (b) Corley, E. G.; Thompson, A. S.; Huntington, M. Org. Synth, 1999, 77, 231.
3. (c) Schoberth, W.; Hanack, M. Synthesis 1972, 703.
4. (d) Liang, S.; Price, T. W.; Nolen, D. B.; Attride, D. C. US Patent 5,502257, 1996; Chem. Abstr. 1996, 125, 10231.
5. (e) Torihara, M.; Minagawa, Y. Japan Patent Application H08-233884, 1996.
6. Fortunak, J. M.; Wang, Z.; Yin, J. Patent, WO 9906341, 1999.
7. Wang, Z.; Yin, J.; Campagna, S.; Pesti, J. A.; Fortunak, J. M. J. Org. Chem. 1999, 64, 6918.
8. Wang, Z.; Campagna, S.; Xu, G.; Yang, K.; Pierce, M. E.; Fortunak, J. M.; Confalone, P. N. J. Org. Chem. 2000, 65, 1889.
9. Corey, E. J.; Fuchs, P. L. Tetrahedron Lett. 1972, 3769.
10. (a) Bandzouzi, A.; Lakhrissi, M.; Chapleur, Y. J. Chem. Soc., Perkin Trans. 1 1992, 1471.
11. (b) Chapleur, Y. J. Chem. Soc., Chem. Commun. 1984, 449.
12. Corey, E. J.; Link, J. O.; Shao, Y. Tetrahedron Lett. 1992, 3435.
13. 4. After filtration a 95% solution yield of CPA in THF:heptane (1:6) was obtained. Fractional distillation at atmosphere pressure (b.p. 54-56°C) afforded neat CPA 1, 1.71 g (89%).