How F(o)-ATPase generates rotary torque

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 355, Issue 1396, 2000, Pages 523-528

  Oster, George ^a   Wang, Hongyun ^a   Grabe, Michael ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ATP synthase; Brownian ratchet; Energy transduction; Mechanochemistry; Molecular motors; Proton pumps

Indexed keywords

MOLECULAR MOTOR; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; REVIEW; TORQUE;

AMINO ACID SEQUENCE; ANIMALS; MODELS, MOLECULAR; MOLECULAR MOTOR PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTON-TRANSLOCATING ATPASES; TORQUE; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 0034728702     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.2000.0593     Document Type: Conference Paper

References (31)

1. 1-ATPase from bovine heart mitochondria. Nature 370, 621-628.
2. +-pumping ATPase variable transport coupling ratio controlled by pH. Proc. Natl Acad. Sci USA 91, 8547-8551.
3. Dimroth, P., Kaim, G. & Matthey, U. 1998 The motor of the ATP synthase. Biochim. Biophys. Acta 1365, 87-92.
4. Dimroth, P., Wang, H., Grabe, M. & Oster, G. 1999 Energy transduction in the sodium F-ATPase of Propionigenium modestum. Proc. Natl Acad. Sci. USA 96, 4924-4929.
5. Elston, T. & Doering, C. R. 1996 Numerical and analytical studies of nonequilibrium fluctuation-induced transport processes. J. Stat. Phys. 83, 359-383.
6. Elston, T., Wang, H. & Oster, G. 1998 Energy transduction in ATP synthase. Nature 391, 510-514.
7. o ATP synthase. Biochim. Biophys. Acta 1365, 135-142.
8. + transport and ATP synthesis in F1F0 ATP synthase. Acta Physiol. Scand. 163, 163-168.
9. +-ATPase of the sugar beet vacuole is reversible. Eur. Biopohys. J. 22, 399-403.
10. o ATP synthase. Biochemistry 37, 8817-8824.
11. Grabe, M., Wang, H. & Oster, G. 2000 The mechanochemistry of the V-ATPase proton pumps. Biophys. J. (In the press.)
12. +-transporting ATP synthase-functional dimers and trimers and determination of stoichiometry by cross-linking analysis. J. Biol. Chem. 273, 29701-29705.
13. o ATP synthase. J. Biol. Chem. 273, 17178-17185.
14. Junge, W, Lill, H. & Engelbrecht, S. 1997 ATP synthase: an electro-chemical transducer with rotatory mechanics. Trends Biochem. Sci. 22, 420-423.
15. 0 ATP synthase of Escherichia coli is obligatorily dependent on the electric potential. FEBS Lett. 434, 57-60.
16. Kaim, G. & Dimroth, P. 1998b Voltage-generated torque drives the motor of the ATP synthase. EMBO J. 17, 5887-5895.
17. Kaim, G. & Dimroth, P. 1999 ATP synthesis by F-type ATP synthase is obligatorily dependent on the transmembrane voltage. EMBO J. 18, 4118-4127.
18. o ATPases. EMBO J. 17, 688-695.
19. o ATP synthase as determined by labeling of unique cysteine residues. J. Biol. Chem. 273, 16235-16240.
20. Matthey, U., Kaim, G., Braun, D., Wüthrich, K. & Dimroth, P. 1999 NMR studies of subunit c of the ATP synthase from Propionigenium modestum in dodecylsulfate micelles. Eur. J. Biochem. 261, 459-467.
21. Mitchell, P. 1979 Keilin's respiratory chain concept and its chemiosmotic consequences. Science 206, 1148-1159.
22. Oster, G. & Wang, H. 2000 Reverse engineering a protein: the mechanochemistry of ATP synthase. Biochim. Biophys. Acta (Bioenergetics) 1458(special issue), 1-30.
23. Parmeggiani, A., Julicher, F., Ajdari, A. & Prost, J. 1999 Energy transduction of isothermal ratchets: generic aspects and specific examples close to and far from equilibrium. Phys. Rev. E. (In the press.)
24. Peskin, C. S., Odell, G. M. & Oster, G. 1993 Cellular motions and thermal fluctuations: the Brownian ratchet. Biophys. J. 65, 316-324.
25. Stock, D., Leslie, A. & Walker, J. 1999 Molecular architecture of the rotary motor in ATP synthase. Science 286, 1700-1705.
26. Taiz, L. & Nelson, N. 1996 Evolution of V-and F-ATPases. In Origin and evolution of biological energy conversion (ed. H. Baltscheffsky), pp. 291-305. New York: VCH Publishers.
27. o ATP synthase. J. Biol. Chem. 273, 16241-16247.
28. o ATP synthases suggested by double mutants of the a subunit. J. Biol. Chem. 269, 30364-30369.
29. 1 motor of ATP synthase. Nature 396, 279-282.
30. 1-ATPase is a highly efficient molecular motor that rotates with discrete 120° steps. Cell 93, 1117-1124.
31. Yokoyama, K., Muneyuki, E., Amano, T., Mizutani, S., Yoshida, M., Ishida, M. & Ohkuma, S. 1998 V-ATPase of Thermus thermophilus is inactivated during ATP hydrolysis but can synthesize ATP. J. Biol. Chem. 273, 20504-20510.