Practical preparation and substitution of configurationally stable aziridinyl ester anions

Tetrahedron Letters

Volumn 41, Issue 5, 2000, Pages 651-654

  Alezra, Valérie ^a   Bonin, Martine ^a   Micouin, Laurent ^a   Husson, Henri Philippe ^a  

^a FACULTÉ DES SCIENCES PHARMACEUTIQUES ET BIOLOGIQUES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AZIRIDINE DERIVATIVE; ESTER DERIVATIVE;

ARTICLE; FRANCE; MOLECULAR INTERACTION; SYNTHESIS; THERMOSTABILITY;

EID: 0034728199     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)02156-5     Document Type: Article

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18. 1H NMR spectra of the quaternary aziridines derived from compound 6 (2R). This phenomenon helped us to evaluate inversion free energy for these compounds to be about 16-17 kcal/mol (T=333 K, DMSO) by classical NMR experiments.
19. 4, filtered and concentrated. The crude reaction product was purified by flash chromatography on silica gel to give the pure alkylated aziridines as colorless oils and about 15-20% of self-condensation product.