From gene to disease; from p16 to melanoma;Van gen naar ziekte; van p16 naar melanoom

Nederlands Tijdschrift voor Geneeskunde

Volumn 144, Issue 44, 2000, Pages 2100-2102

  Gruis, N A ^a   Bergman, W ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

CANCER SUSCEPTIBILITY; FAMILIAL DISEASE; GENE MAPPING; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; MELANOMA; NEVUS; REVIEW; SKIN CANCER; TUMOR SUPPRESSOR GENE;

CELL DIVISION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DYSPLASTIC NEVUS SYNDROME; GENES, P16; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HUMANS; MELANOMA; MUTATION; NETHERLANDS; SKIN NEOPLASMS;

EID: 0034727489     PISSN: 00282162     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (9)

1. Clinical and genetic studies in six Dutch kindreds with the dysplastic naevus syndrome
2. On naevi and melanomas in dysplastic naevus syndrome patients
3. The familial dysplastic nevus syndrome. Natural history and the impact of screening on prognosis. A study of nine families in the Netherlands
4. Systemic cancer and the FAMMM syndrome
5. Excess cancer mortality in six Dutch pedigrees with the familial atypical multiple mole-melanoma syndrome from 1830 to 1994
6. Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds
7. A cell cycle regulator potentially involved in genesis of many tumor types
8. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
9. CDKN2 explains part of the clinical phenotype in Dutch familial atypical multlple-mole melanoma (FAMMM) syndrome families