Necessity of conserved asparagine residues in the leucine-rich repeats of platelet glycoprotein Ibα for the proper conformation and function of the ligand-binding region

Biochemistry

Volumn 39, Issue 12, 2000, Pages 3384-3391

  Afshar Kharghan, Vahid ^a   Gineys, Garunee ^a   Schade, Alicia J ^b   Sun, Lily ^a   Li, Chester Q ^a   McIntire, Larry V ^b   Dong, Jing Fei ^a   López, José A ^a  

^a MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b RICE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; GLYCOPROTEIN IB; LEUCINE; LYSINE; MESSENGER RNA; RISTOCETIN; SERINE; VON WILLEBRAND FACTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; LIGAND BINDING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONFORMATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHEAR STRESS; TANDEM REPEAT; THROMBOCYTE MEMBRANE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ASPARAGINE; BINDING SITES, ANTIBODY; CELL ADHESION; CELL MOVEMENT; CHO CELLS; CONSERVED SEQUENCE; CRICETINAE; HUMANS; LEUCINE; LIGANDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; REPETITIVE SEQUENCES, AMINO ACID; TRANSFECTION; VON WILLEBRAND FACTOR;

ANIMALIA;

EID: 0034724172     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992061j     Document Type: Article

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