Neurotoxicity of ethyl methacrylate in rats

Journal of Toxicology and Environmental Health - Part A

Volumn 59, Issue 2, 2000, Pages 97-118

  Abou Donia, Mohamed B ^a   Abdel Rahman, Ali A ^a   Kishk, Amal M ^a   Walker, David ^a   Markwiese, Barbara J ^b   Acheson, Shawn K ^c   Reagan, Katherine E ^d   Swartzwelder, Scott ^e   Jensen, Karl F ^f  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b BIOANALYTICAL SYSTEMS INC   (United States)

^c EAST CAROLINA UNIVERSITY   (United States)

^d Nickel Producers Environmental Research Association   (United States)

^e Department of Veterans   (United States)

^f U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRINKING WATER; ETHYL METHACRYLATE; METHACRYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; BRAIN; BREATHING DISORDER; CELL DENSITY; CONTROLLED STUDY; DOSE RESPONSE; GROWTH INHIBITION; LETHARGY; MALE; MORTALITY; MOTOR ACTIVITY; MYELIN SHEATH; NERVE FIBER DEGENERATION; NEUROTOXICITY; NONHUMAN; OCCUPATIONAL EXPOSURE; PERITONEUM; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SPINAL CORD; TASK PERFORMANCE;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, INTRAPERITONEAL; MALE; MAZE LEARNING; METHACRYLATES; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATION; SCIATIC NERVE; SLEEP STAGES; SPINAL CORD;

ANIMALIA;

EID: 0034723398     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/009841000157005     Document Type: Article

References (54)

1. Abou-Donia, M. B. 1995. Metabolism and toxicokinetics of xenobiotics. In CRC handbook of toxicology, eds. M. J. Derelanko, and M. A. Hollinger, pp. 539-589. Boca Raton, FL: CRC Press.
2. Abou-Donia, M. B., Ibrahim, S. M., Corcoran, J. J., Lack, L., Friedman, M., and Lapadula, D. M., 1993. Neurotoxicity of glycidamide, an acrylamide metabolite, following intraperitoneal injection in rats. J. Toxicol. Environ. Health 39:447-464.
3. Abou-Donia, M. B., Wilmarth, K. R., Jensen, K. F., Oehme, F. W., and Kurt, T. L. 1996. Neurotoxicity resulting from coexposure to pyridostigmine bromide, DEET, and permethrin: Implications of Gulf War chemical exposures. J. Toxicol. Environ. Health 48:35-56.
4. Allen, I. V., and Kirk, J. 1992. Demyelinating diseases. In Greenfield's neuropathology, 5th ed., eds. J. H. Adams and L. W. Duchen, pp. 447-520. New York: Oxford University Press.
5. Anonymous. 1995. Final report on ethyl methcrylate. J. Am. Cell. Toxicol. 14:452-467.
6. Bohling, H. G., Borchard, U., and Drouin, H. 1977. Monomeric methylmethacrylate acts on desheathed myeli nated nerve and on node of Ranvier. Arch. Toxicol. 38:307-317.
7. Bratt, H., and Hathway, D. E. 1977. Fate of methyl methacrylate in rats. Br. J. Cancer 36:114-119.
8. Calleman, C. J., Bergmark, E., and Costa, L. G. 1990. Acrylamide is metabolized to glycidamide in the rat. Evidence from hemoglobin adduct formation. Chem. Res. Toxicol. 3:406-412.
9. 14C]acrylamide to proteins in the mouse nervous system. Neurochem. Int. 18: 191-197.
10. Corkill, J. A., Lloyd, E. J., Hoyle, P., Crout, D. H. G., Ling, R. S. M., James, M. L., and Piper, R. J. 1976. Toxicology of methyl methacrylate: The rate of disappearance of methyl methacrylate in human blood in vitro. Clin. Chim. Acta 68:141-146.
11. Cronin, E. 1980. Contact dermatitis, p. 584. Edinburgh: Churchill Livi ngstone.
12. de Groot, A. C., Weyland, J. W., and Nater, J. P. 1994. Unwanted effects of cosmetics and drugs used in dermatology, 3rd ed. New York: Elsevier.
13. Deichmann, W. B. 1941. Toxicity of methyl, ethyl, and N-butyl methacrylate. J. Ind. Hyg. 23:343-351.
14. Dixon, M. 1948. Reaction of lachrymators with enzymes and proteins. Biochem. Sec. Symp. 2:39-49.
15. Frederick, C. B., and Reynolds, C. H. 1989. Modeling the reactivity of acrylic acid and acrylate anion with biological nucleophiles. Toxicol. Lett. 47:241-247.
16. Frederick, C. B., Hazelton, G. A., and Frantz, J. D. 1990. The histopathological and biochemical response of the stomach of male F344/N rats following 2weeks of oral dosing with ethyl acrylate. Toxicol. Pathol. 18:247-256.
17. Freeman, M. A. R. 1976. Current state of total joint replacement. Br. Med. J. 2:1301.
18. Fries, I. D., Fisher, A. A., and Salvati, E. A. 1975. Contact dermatitis in surgeons from methyl methacrylate bone cement. J. Bone Joint Surg. 57a:547-549.
19. Froines, J. R., and Garabrant, D. H. 1986. Quantitative evaluation of manicurists exposure to methyl, ethyl, and isobutyl methacrylate during production of synthetic fingernails. Appl. Ind. Hyg. 1: 70-74.
20. Fujisawa, S., Kadoma, Y., and Masuhara, E. 1984. A calorimetric study of the interaction of synthetic phospholipid liposomes with vinyl monomers, acrylates, and methacrylates. J. Biomed. Mater. Res. 18:1105-1114.
21. Ghanayem, B. I., Maronpot, R. R., and Matthews, H. B. 1985a. Ethyl acrylate-induced gastric toxicity. I. Effect of single and repetitive dosing. Toxicol. Appl. Pharmacol. 80:323-335.
22. Ghanayem, B. I., Maronpot, R. R., and Matthews, H. B. 1985b. Ethyl acrylate-induced gastric toxicity. II. Structure-toxicity relationships and mechanism. Toxicol. Appl. Pharmacol. 80:336-344.
23. Ghanayem, B. I., Maronpot, R. R., and Matthews, H. B. 1986. Ethyl acrylate-induced gastric toxicity. III. Development and recovery of lesion. Toxicol. Appl. Pharmacol. 83:576-583.
24. Gibson, G. G., and Skett, P. 1994. Introduction to drug metabolism, 2nd ed., pp. 114-120. New York: Black Academic and Professional.
25. Gupta, R. P., and Abou-Donia, M. B. 1996. Alterations in the neutral proteinase activities of central and peripheral nervous systems of acrylamide-, carbon disulfide-, or 2,5-hexanedione-treated rats. Mol. Chem. Neuropathol. 29:53-66.
26. Gupta, R. P., and Abou-Donia, M. B. 1997. Acrylamide and carbon disulfide treatments increase the rate of rat brain tubulin polymerization. Mol. Chem. Neuropathol. 30:223-237.
27. Hiipakka, D., and Samimi, B. 1987. Exposure of acrylic fingernail sculpters to organic vapors and methacrylate. Am. Ind. Hyg. Assoc. J. 48:230-237.
28. Homsy, C. A., Tullos, H. S., Anderson, M. S., Differante, N. M., and King, J. W. 1972. Some physiological aspects of prosthesis stabilisation and acrylic polymer. Clin. Orthop. 83:317-328.
29. Innes, D. L., and Tansy, M. F. 1981. Central nervous system effects of methyl methacrylate vapor. Neurotoxicology 2:515-522.
30. Kanerva, L., Lauerma, A., Tstlander, T., Alanko, K., and Henriks-Eckerman, M.-L. 1996. Occupational allergic contact dermatitis caused by photobonded sculptured nails and a review of (meth)acry-lates in nail cosmetics. Am. J. Contact Dermatol. 7:109-115.
31. Kim, K. C., and Ritter, M. A. 1972. Hypotension associated with methyl methacrylate in total hip arthroplasties. Clin. Orthop. 88:154-160.
32. Koestner, A., and Norton, S. 1991. Nervous system. In Toxicologic pathology, eds. W. Haschek and C. Rousseaux, pp. 625-674. New York: Academic Press.
33. 14C]acrylamide to neurofilament and microtubule proteins of rats. Brain Res. 481:159-191.
34. Lawrence, W. H., Malik, M., and Autian, J. 1974. Development of a toxicity evaluation program for dental materials and products. II. Screening for systemic toxicity. J. Biomed. Mater. Res. 8:1134.
35. Lozewicz, E., Davison, A. G., Hopkirk, A., Burge, P. S., Boldy, D. A. R., Riordan, J. F., McGivern, D. W., Platts, B. W., Davies, D., and Newman Taylor, A. J. 1985. Occupational asthma due to methyl methacrylate and cyanoacrylates. Thorax 40:836-839.
36. Miller, R. R., Ayers, J. A., Rampy, L. W., and McKenna, M. J. 1981. Metabolism of acrylate esters in rat tissue homogenates. Fundam. Appl. Toxicol. 1:410-414.
37. Mir, G. N., Lawrence, W. H., and Autian, J. 1973. Toxicological and pharmacological actions of methacrylate monomers I: Effects on isolated, perfused rabbit heart. J. Pharm. Sci. 62:778-782.
38. Morgan, E. T. 1997. Regulations of cytochrome P450 during inflammation and infection. Drug Metab. Rev. 29:1129-1188.
39. Nemec, J. W., and Kirch, L. S. 1981. Methacrylic acid and derivatives. In Kirk-Othmer encyclopedia of chemical technology, eds. M. Grayson, D. Eckroth, vol. 15, 3rd ed., pp. 346-377. New York: John Wiley and Sons.
40. Oberly, R., and Tansy, M. F. 1985. LC50 values for rats acutely exposed to vapors of acrylic and methacrylic acid esters. J. Toxicol. Environ. Health 16:811-822.
41. Peters, A., Palay, S. L., and Webster, H. D. 1991. The fine structure of the nervous system, 3rd ed. New York: Oxford University Press.
42. Potter, D. W., and Tran, T. B. 1992. Rates of ethyl acrylate binding to glutathione and protein. Toxicol. Lett. 62:275-285.
43. Rajanieme, R., and Tola, S. 1985. Subjective symptoms among dental technicians exposed to the monomer methyl methacrylate. Scand. J. Work Environ. Health 11:281-286.
44. Reagan, K. E., Wilmarth, K. R., Friedman, M., and Abou-Donia, M. B. 1994. Acrylamide increases in vitro calcium and calmodulin-dependent kinase-mediated phosphorylation of rat brain and spinal cord neurofilament proteins. Neurochem. Int. 25:133-143.
45. Reagan, K. E., Wilmarth, K. R., Friedman, M., and Abou-Donia, M. B. 1995. In vitro calcium and calmodulin-dependent kinase-mediated phosphorylation of rat brain and spinal cord neurofilament proteins is increased by glycidamide administration. Brain Res. 671:12-20.
46. Seppalainen, A. M., and Rajanieme, R. 1984. Local neurotoxicity of methyl methacrylate among dental technicians. Am. J. Ind. Med. 5:471-477.
47. Silver, E. H., and Murphy, S. D. 1981. Potentiation of acrylate ester toxicity by prior treatment with carboxylesterase inhibitor triorthotoyl phosphate (TOTP). Toxicol. Appl. Pharmcol. 57:208-219.
48. Spealman, C. R., Main, R. J., Haag, H. B., and Larson, P. S. 1945. Monomeric methylmethacrylate. Studies on toxicity. Ind. Med. 14:292-298.
49. Spencer, P. S., and Bischoff, M. C. 1982. Contemporary neuropathological methods in toxicology. In Nervous systems and toxicology, ed. C. L. Mitchell, pp. 259-275. New York: Raven Press.
50. 13C nuclear magnetic resonance spectroscopy. Chem. Res. Toxicol. 5:81-89.
51. Tanii, H., and Hashimoto, K. 1982. Structure-toxicity relationships of acrylates and methacrylates. Toxicol. Lett. 11:125-129.
52. Tansy, M. F., and Kendall, F. M. 1979. Update on the toxicity of inhaled methyl methacrylate vapor. Drug Chem. Toxicol. 2:315-330.
53. Tansy, M. R., Benhayem, S., Probst S., and Jordan, J. S. 1974. The effects of methyl methacrylate vapor on gastric motor function. J. Am. Dent. Assoc. 89:372-376.
54. Waxman, S. G. 1978. Physiology and pathobiology of axons. New York: Raven Press.