Local secretion of a chimeric anti-CD4 antibody protects against graft rejection in the nod mouse

Transplantation

Volumn 69, Issue 8, 2000, Pages 1745-1748

  McKenzie, Andrew W ^a   Brady, Jamie L ^a   Martin, Roland M ^a,b   Georgiou, Harry M ^a,c   Lew, Andrew M ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b CSL LIMITED   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; CHIMERA; CONTROLLED STUDY; GENETIC TRANSFECTION; GRAFT REJECTION; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; INSULINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIMIAN VIRUS 40; THYMOCYTE;

EID: 0034720080     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200004270-00041     Document Type: Article

References (20)

1. Molecular biology and function of CD4 and CD8
2. The effect of a depleting anti-CD4 monoclonal antibody on T cells and fetal pig islet xenograft survival in various strains of mice
3. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: Similarity of L3T4 to the human Leu-3/T4 molecule
4. Islet allograft survival after a single course of treatment of recipient with antibody to L3T4
5. Role of the L3T4+ T cell in allograft rejection
6. Fetal pig pancreas xenografts in non-obese diabetic mice treated with continuous anti-CD4 monoclonal antibody
7. Effect of GK1.5 monoclonal antibody dosage on survival of pig proislet xenografts in CD4+ T cell-depleted mice
8. Prolonged survival of nonhuman primate renal allograft recipients treated only with anti-CD4 monoclonal antibody
9. Murine OKT4A immunosuppression in cadaver donor renal allograft recipients: A cooperative clinical trials in transplantation pilot study
10. Secretion of CTLA4Ig by an SV40 T antigen-transformed islet cell line inhibits graft rejection against the neoantigen
11. Limited capacity for tolerization of CD4+ T cells specific for a pancreatic beta cell neo-antigen
12. The Igh-1 sequence of the non-obese diabetic (NOD) mouse assigns it to the IgG2c isotype
13. Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction
14. The need for IgG2c specific antiserum when isotyping antibodies from C57BL/6 and NOD mice
15. CD4+ T cell help impairs CD8+ T cell deletion induced by cross- presentation of self-antigens and favors autoimmunity
16. Skin allograft rejection by L3/T4+ and Lyt-2+ T cell subsets
17. Immunomodulation of pancreatic islet allografts in mice with CTLA4Ig secreting muscle cells
18. Expression of CTLA4-Ig by biolistically transfected mouse islets promotes islet allograft survival
19. Effect of gene gun-mediated CTLA4IG and Fas ligand gene transfection on concordant xenogeneic islet graft rejection
20. Comparison of GK1.5 and chimeric rat/mouse GK1.5 anti-CD4 antibodies for prolongation of skin allograft survival and suppression of alloantibody production in mice