Neomarinone, and new cytotoxic marinone derivatives, produced by a marine filamentous bacterium (actinomycetales)

Tetrahedron Letters

Volumn 41, Issue 13, 2000, Pages 2073-2076

  Hardt, Ingo H ^a   Jensen, Paul R ^a   Fenical, William ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Marine bacteria; Mixed biosynthesis; Naphthoquinone

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; MARINONE DERIVATIVE; NEOMARINONE; UNCLASSIFIED DRUG;

ACTINOBACTERIA; ARTICLE; CANCER CELL; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE;

ACTINOBACTERIA (CLASS); ACTINOMYCETALES; BACTERIA (MICROORGANISMS); UNCULTURED ACTINOMYCETE;

EID: 0034719903     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00117-9     Document Type: Article

References (15)

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8. Bacterial strain CNH-099 was isolated from a sediment sample (collected at -1 m, Batiquitos Lagoon) using serial dilution and plating techniques on medium A1 (1.6% agar, 1% starch, 0.4% yeast extract, 0.2% peptone, 100% seawater). As in the original strain producing marinone (CNB-384), strain CNH-099 could not be assigned to any known actinomycete genus by fatty acid methyl ester (FAME) analysis (Microbial ID Inc., Newark, DE).
9. Bacterial strain CNH-099 was cultivated in 26×1 L volumes in Fernbach flasks. The flasks were shaken at 230 rpm at 23°C for 8-10 days.
10. max (ε)]: (MeOH+HCl): 455 (2100), 385 (2700), 325 (sh 5300), 308 (5900), 283 (12400), 275 (12000), 228 (sh 13200), 208 nm (17800), (MeOH+KOH): 525 (3000), 354 (6000), 298 (10000), 250 nm (15900).
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