Synthesis of novel spirocyclic cocaine analogs using the Suzuki coupling

Tetrahedron Letters

Volumn 41, Issue 13, 2000, Pages 2055-2058

  Sakamuri, Sukumar ^a   George, Clifford ^b   Flippen Anderson, Judith ^b   Kozikowski, Alan P ^a  

^a Georgetown Inst Cogn Compl Sci   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CYCLIZATION; DRUG CONFORMATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; REACTION ANALYSIS; STEREOSPECIFICITY;

EID: 0034719741     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00113-1     Document Type: Article

References (20)

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16. 3, 300 MHz) δ 7.40-7.32 (m, 1H), 7.16-7.08 (m, 3H), 3.66 (d, J=11.5 Hz, 1H), 3.58-3.41 (m, 6H), 3.35 (narrow m, 1H), 2.46 (s, 3H), 2.38 (narrow m, 1H), 2.26-2.14 (m, 3H), 1.96-1.63 (m, 2H).
17. Atomic coordinates for all four structures have been deposited with the Cambridge Crystallographic Data Base, 12 Union Road, Cambridge CB2 1EZ, UK (deposit@ccdc.cam.ac.uk).
18. Trost, B. M.; Curran, D. P. Tetrahedron Lett. 1981, 22, 1287-1290.
19. Handa, Y.; Inanaga, J.; Yamaguchi, M. J. Chem. Soc., Chem. Commun. 1989, 298-299.
20. We thank Dr. Kenneth M. Johnson for providing the uptake data.