Multiple system atrophy/progressive supranuclear palsy: α-Synuclein, synphilin, tau, and APOE

Neurology

Volumn 55, Issue 12, 2000, Pages 1918-1920

  Morris, H R ^a,c   Vaughan, J R ^a   Datta, S R ^a   Bandopadhyay, R ^c   Rohan De Silva, H A ^a,c   Schrag, A ^a   Cairns, N J ^b   Burn, D ^d   Nath, U ^d   Lantos, P L ^b   Daniel, S ^a   Lees, A J ^a,c   Quinn, N P ^a   Wood, N W ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d ROYAL VICTORIA INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; APOLIPOPROTEIN E; GENE PRODUCT; SYNPHILIN; TAU PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GENE INSERTION; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; SHY DRAGER SYNDROME;

EID: 0034719060     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.55.12.1918     Document Type: Article

References (10)

1. Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)
2. Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
3. Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions
4. Synphilin-1 is present in Lewy bodies in Parkinson's disease
5. Apolipoprotein E e4 allele frequency in patients with multiple system atrophy
6. CYP2D6-debrisoquine hydroxylase gene polymorphism in multiple system atrophy
7. Association of an extended haplotype in the tau gene with progressive supranuclear palsy
8. Multiple system atrophy: A sporadic synucleinopathy
9. No mutation in the entire coding region of the alpha-synuclein gene in pathologically confirmed cases of multiple system atrophy
10. Progressive supranuclear gaze palsy is in linkage disequilibrium with the tau and not the alpha-synuclein gene