Reaction mechanism of the macrophomate synthase: Experimental evidence on intermediacy of a bicyclic compound

Tetrahedron Letters

Volumn 41, Issue 9, 2000, Pages 1443-1446

  Watanabe, Kenji ^a   Mie, Takashi ^a   Ichihara, Akitami ^a   Oikawa, Hideaki ^a   Honma, Mamoru ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Enzyme reaction; Enzymes; Mechanisms

Indexed keywords

BENZOIC ACID DERIVATIVE; COUMARIN DERIVATIVE; OXALOACETIC ACID; SYNTHETASE;

ARTICLE; CATALYST; CHEMICAL REACTION; CHEMICAL STRUCTURE; ENZYME MECHANISM; REACTION ANALYSIS; STRUCTURE ANALYSIS;

EID: 0034716547     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)02311-4     Document Type: Article

References (9)

1. Oikawa, H.; Watanabe, K.; Yagi, K.; Ohashi, S.; Mie, T.; Ichihara, A.; Honma, M. Tetrahedron Lett. 1999, 40, 6983-6986.
2. Watanabe, K.; Mie, T.; Ichihara, A.; Oikawa, H.; Honma, M. Biosci. Biotechnol. Biochem. in press.
3. Widlanski, T. S.; Bender, S. L.; Knowles, J. R. J. Am. Chem. Soc. 1987, 109, 1873-1875; Widlanski, T. S.; Bender, S. L.; Knowles, J. R. J. Am. Chem. Soc. 1989, 111, 2299-2300.
4. Widlanski, T. S.; Bender, S. L.; Knowles, J. R. J. Am. Chem. Soc. 1987, 109, 1873-1875; Widlanski, T. S.; Bender, S. L.; Knowles, J. R. J. Am. Chem. Soc. 1989, 111, 2299-2300.
5. Iwase, N.; Kudo, F.; Yamauchi, N.; Kakinuma, K. Biosci., Biotechnol. Biochem. 1998, 62, 2396-2407.
6. ++H) calcd: 243.0505; found: 243.0487.
7. ++H) calcd: 257.0661; found: 257.0652.
8. 3J (C,H)=7 Hz. See: Bax, A.; Summers, M. F. J. Am. Chem. Soc. 1986, 108, 2093-2094.
9. Fukushi, Y.; Yajima, C.; Mizutani, J. Tetrahedron Lett. 1994, 35, 599-602.