A novel microbial metabolite, activator of low density lipoprotein receptor promoter

Tetrahedron Letters

Volumn 41, Issue 9, 2000, Pages 1351-1354

  Hegde, Vinod R ^a   Puar, Mohindar S ^a   Dai, Ping ^a   Patel, Mahesh ^a   Gullo, Vincent P ^a   Das, Pradip R ^a   Bond, Richard W ^a   McPhail, Andrew T ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTONE DERIVATIVE; LOW DENSITY LIPOPROTEIN RECEPTOR; SCH 351448; UNCLASSIFIED DRUG;

ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; FERMENTATION; MICROMONOSPORA; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

EID: 0034716518     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)02291-1     Document Type: Article

References (10)

1. Yokoyama, C.; Wang, X. D.; Briggs, M. R.; Admon, A.; Wu, J.; Hua, X. X.; Goldstein, J. L.; Brown, M. S. Cell 1993, 75, 187.
2. Sakai, J.; Rawson, R. B.; Espenshade, P. J.; Cheng, D.; Seegmiller, A. C.; Goldstein, J. L.; Brown, M. S. Mol. Cell 1998, 2, 505.
3. 5 upstream of the hGH gene was also run concurrently. By comparing the results from the two assays we could find compounds which were not general transcriptional activators but rather may be specifically activating transcription from the LDL-R promoter.
4. Bullen, H.; Wilkin, T. J. J. Immunol. Methods 1989, 121, 247.
5. Takebe, Y.; Seiki, M.; Fujisawa, J. I.; Hoy, P.; Yokota, K.; Arai, K. I.; Yoshida, M.; Arai, N. Mol. Cell. Biol. 1988, 8, 466.
6. Hexane-rich upper phase was used as mobile phase and methanol-rich lower phase was used as lower phase. Column was rotated at 1000 rpm; flow rate: 6 mL/min; detection: UV, 225 nm.
7. max=52°). Coordinates have been deposited at the Cambridge Crystallographic Data Centre.
8. Hydrogen-bonded distances (Å): O5.O2=2.531(15), O5′.O6′=2.519(13), bifurcated O4.O1=2.940(12) and O4.O3=2.753(12) and bifurcated O4′.O1′=2.773(13) and O4′.O3′=2.785(12).
9. Na-O1=2.724(10), Na-O4=2.407(8), Na-O5=2.426(8), Na-O6=2.445(10), Na-O1′=2.402(10), Na-O4′=2.721(9), Na-O6′ 2.393(8) Å.
10. Liu, J. W.; Streiff, R.; Zhang, Y. L.; Vestal, R. E.; Spence, M. J.; Briggs, M. R. J. Lipid Res. 1997, 38, 2035.