Differential phosphorylation of the HPV-16 E7 oncoprotein during the cell cycle

Virology

Volumn 276, Issue 2, 2000, Pages 388-394

  Massimi, P ^a   Banks, L ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

CKII; E7; HPV; Phosphorylation

Indexed keywords

CASEIN KINASE II; ONCOPROTEIN; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE S PHASE; CELL IMMORTALIZATION; CONTROLLED STUDY; ENZYME SPECIFICITY; GENE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; WART VIRUS;

EID: 0034715522     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2000.0514     Document Type: Article

References (21)

1. The human papillomavirus type 16 E7 gene product interacts with and transactivates the AP-1 family of transcription factors
2. Cyclin A and the retinoblastoma gene product complex with a common transcription factor
3. Analysis of human papillomavirus type 16 polypeptides in transformed primary cells
4. Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells
5. HPV-16 E7 functions at the G1 to S phase transition in the cell cycle
6. The region of the HPV E7 oncoprotein homologous to adenovirus E1a and SV40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation
7. Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation
8. The human papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
9. Negative charge at the casein kinase II phosphorylation site is important for transformation but not for Rb protein binding by the E7 protein of human papillomavirus type 16
10. Serum-stimulated cell cycle entry of fibroblasts requires undisturbed phosphorylation and non-phosphorylation interactions of the catalytic subunits of protein kinase CK2
11. HPV-16 E7 and adenovirus E1a complex formation with TATA box binding protein is enhanced by casein kinase II phosphorylation
12. Human papillomavirus type 16 E7 binds to the conserved carboxy-terminal region of the TATA box binding protein and this contributes to E7 transforming activity
13. Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development
14. Casein kinase II is required for transition of G0/G1, early G1, and G1/S phases of the cell cycle
15. Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism
16. Casein kinase II phosphorylates p34cdc2 kinase in G1 phase of the HeLa cell division cycle
17. Mutations of the human papillomavirus type 16 E7 gene that affect transformation, transactivation and phosphorylation by the E7 protein
18. Inhibition of Bak induced apoptosis by HPV-18 E6
19. HPV16 E7 protein associates with the protein kinase p33CDK2 and cyclin A
20. The role of papillomaviruses in human anogenital cancers
21. 2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein