Transcriptional activation of the granulocyte-macrophage colony-stimulating factor receptor gene in cell mutants

Experimental Cell Research

Volumn 259, Issue 1, 2000, Pages 1-11

  Laker, Christine ^a   Friel, Jutta ^a   Franz, Marie Josée ^a   Hara, Takahiko ^b   Papadopoulos, Panos ^a   Ostertag, Wolfram ^a   Stocking, Carol ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

DNA rearrangements; Gene structure; GM CSF receptor; Retroviral insertional mutagenesis

Indexed keywords

CYTOKINE ANTIBODY; DNA; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL MUTANT; CELL PROLIFERATION; CONTROLLED STUDY; ENHANCER REGION; GENE INSERTION; GENE LOCUS; GENE MUTATION; GENE STRUCTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROMYELOCYTE; RETROVIRUS; TRANSCRIPTION REGULATION; VIRUS GENE;

ANIMALIA; UNIDENTIFIED RETROVIRUS;

EID: 0034714573     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.4971     Document Type: Article

References (40)

1. Activation of a cellular oncogene by promoter insertion in ALV-induced lymphoid leukosis
2. Integration of the DNA of mouse mammary tumor virus in virus-infected normal and neoplastic tissue of the mouse
3. The integrated genome of murine leukemia virus
4. Retroviral insertional mutagenesis as a strategy to identify cancer genes
5. Germline integration of Moloney murine leukemia virus at the Mov13 locus leads to recessive lethal mutations and early embryonic death
6. Retrovirus and insertional mutagenesis in mice: Proviral integration at the Mov34 locus leads to early embryonic death
7. Gene trapping and functional genomics
8. Bcl-x is the major pleiotropic anti-apoptotic gene activated by retroviral insertion mutagenesis in an IL-3 dependent bone marrow derived cell line
9. Identification of genes involved in growth autonomy of hematopoietic cells by analysis of factor independent mutants
10. Distinct classes of factor-independent mutants can be isolated after retroviral mutagenesis of a human myeloid stem cell line
11. Replacement of interleukin-2 (IL-2)-generated mitogenic signals by a mink cell focus-forming (MCF) or xenotropic virus-induced IL-9-dependent autocrine loop: Implications for MCF virus-induced leukemogenesis
12. Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: Identification of the bcar-1, a common integration site
13. Retroviral insertional mutagenesis as a strategy for the identification of genes associated with cis-diamminedichloroplatinum(II) resistance
14. Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for rho-like proteins
15. Development of multipotential hematopoietic stem cells to neutrophils is associated with increased expression of receptors for granulocate/macrophage colony stimulating factor: Altered biological response to GM-CSF during development
16. The molecular control of cell division, differentiation commitment and maturation in hematopoietic cells
17. Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5
18. Sequential mutations in the IL3/GM-CSF/IL5 receptor β-subunit genes are necessary for the complete conversion to growth autonomy mediated by a truncated β(c)-subunit
19. Growth of factor-independent hemopoietic precursor cell lines
20. Autocrine stimulation after transfer of the granulocyte/macrophage colony-stimulating factor gene and autonomous growth are distinct but interdependent steps in the oncogenic pathway
21. Macrophage cell lines transformed by the malignant histiocytosis sarcoma virus: Increase of CSF receptors suggests a model for transformation
22. Retrotransposons as mutagens in the induction of growth autonomy in hematopoietic cells
23. Basic local alignment search tool
24. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein cut
25. The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype
26. Isolation of a cDNA encoding a novel zinc-finger protein from neuroblastoma x glioma NG108-15 cells
27. b family of antibodies: Somatic mutation evident in a γ2a variable region
28. A new bipartite DNA-binding domain: Cooperative interaction between the cut repeat and homeo domain of the cut homeo proteins
29. Altering the genome by homologous recombination
30. Insertional mutation of 'classical' and novel genes in transgenic mice
31. Expression of the GM-CSF gene after retroviral transfer in hematopoietic stem cell lines induced synchronous granulocyte-macrophage differentiation
32. Mutants of a multipotent hematopoietic cell line blocked in GM-CSF-induced differentiation are leukemogenic in vivo
33. In vivo transformation of factor-dependent hemopoietic cells: Role of intracisternal A-particle transpostion for growth factor gene activation
34. Alternating purine-pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumors
35. Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5
36. DNA bending creates favored sites for retroviral integration: An explanation for preferred insertion sites in nucleosomes
37. Distribution of targets for avian retrovirus DNA integration in vivo
38. Retroviral mutagenesis of cellular oncogenes: A review with insights into the mechanism of insertional activation
39. Cloning of the low-affinity murine granulocyte-macrophage colony-stimulating factor receptor and reconstitution of a high-affinity receptor complex