Structure of the utrophin actin-binding domain bound to F-actin reveals binding by an induced fit mechanism

Journal of Molecular Biology

Volumn 297, Issue 2, 2000, Pages 465-480

  Moores, Carolyn A ^a   Keep, Nicholas H ^b   Kendrick Jones, John ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Actin; Dystrophin; Image reconstruction; Pseudo atomic model; Utrophin

Indexed keywords

ACTIN; ALPHA ACTININ; CALPONIN; DYSTROPHIN; F ACTIN; FODRIN; SPECTRIN; UTROPHIN;

ARTICLE; CRYOELECTRON MICROSCOPY; CRYSTAL STRUCTURE; ESCHERICHIA COLI; IMAGE RECONSTRUCTION; MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

EID: 0034708341     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3583     Document Type: Article

References (59)

1. Structural comparisons of calponin homology domains: Implications for actin binding
2. Utrophin: A structural and functional comparison to dystrophin
3. Towards atomic interpretation of F-actin filament three-dimensional reconstructions
4. Crystal structure of a calponin homology domain
5. Arrangement of the heads of myosin in relaxed thick filaments from Tarantula muscle
6. MRC image processing programs
7. Fimbrin is a homologue of the cytoplasmic phosphoprotein plastin and has domains homologous with calmodulin and actin gelation proteins
8. Reconstruction of three-dimensional images from electron micrographs of structures with helical symmetry
9. Cryo-electron microscopy of vitrified specimens
10. An algorithm for straightening images of curved filamentous structures
11. Cortexillins, major determinants of cell shape and size, are actin-bundling proteins with a parallel coiled-coil tail
12. The structure of an actin-crosslinking domain from human fimbrin
13. Evidence for a conformational change in actin induced by fimbrin (N375) binding
14. An atomic model of fimbrin binding to F-actin and its implications for filament cross-linking and regulation
15. Analysis of the actin-binding domain of α-actinin by mutagenesis and demonstration that dystrophin contains a functionally homologous domain
16. 3D reconstruction of reconstituted smooth muscle thin filaments containing calponin: Visualisation of interactions between F-actin and calponin
17. VMD: Visual molecular dynamics
18. Improved methods for the building of protein models in electron density maps and the location of errors in these models
19. The 2.0 Å structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin
20. Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimer
21. Diffraction by helical structures
22. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
23. Refinement of the F-actin model against X-ray fiber diffraction data by the use of a directed mutation algorithm
24. Structural basis for dimerisation of the Dictyostelium gelation factor (ABP120) rod
25. F-actin binding proteins
26. Determination of the α-actinin binding site on actin filaments by cryoelectron microscopy and image analysis
27. Cofilin changes the twist of F-actin: Implications for actin filament dynamics and cellular function
28. Determination of the gelsolin binding site on F-actin: Implications for severing and capping
29. Raster3D: Photo-realistic molecular graphics
30. Structural relationships of actin, myosin and tropomyosin revealed by cryo-electron microscopy
31. Molecular structure of F-actin and location of surface binding sites
32. Image analysis of electron micrographs
33. Disruption of the utrophin-actin interaction by monoclonal antibodies and prediction of an actin-binding surface of utrophin
34. Dystrophin-related protein is localised to neuromuscular junctions of adult skeletal muscle
35. Structural basis for the destabilisation of F-actin by phosphate release following ATP hydrolysis
36. Structural dynamics of F-actin. I. Changes in the C terminus
37. Evolution of the spectrin repeat
38. Utrophin expression during human fetal development
39. Searching for the 1 in 2400000: A review of dystrophin gene point mutations
40. XIMDISP: A visualisation tool to aid structure determination from electron microscope images
41. Evaluating atomic models of F-actin with an undecagold-tagged phalloidin derivative
42. Structure of Limulus telson muscle thick filaments
43. The variable twist of actin and its modulation by actin-binding proteins
44. CH domains revisited
45. Herpes simplex virus L particles contain spherical membrane-enclosed inclusion vesicles
46. Projection image of smooth muscle α-actinin from two-dimensional crystals formed on positively charged lipid layers
47. CLUSTAL W: Improving sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix
48. Primary structure of dystrophin-related protein
49. Increasing complexity of the dystrophin-associated protein complex
50. Expression of full-length utrophin prevents muscular dystrophy in mdx mice
51. Localisation of dystrophin in skeletal, cardiac and smooth muscle
52. Structure-function relationships in dystrophin and utrophin
53. The membrane-cytoskeleton interface: The role of dystrophin and utrophin
54. Protein production in three different expression vectors from a single polymerase chain reaction product
55. Utrophin actin-binding domain: Analysis of actin-binding and cellular targeting
56. Dystrophin and utrophin: The missing links
57. Protein structure
58. Situs: A package for docking crystal structures into low-resolution maps from electron microscopy