A marine diterpene with a novel tetracyclic framework from the West Indian gorgonian octocoral Pseudopterogorgia elisabethae

Organic Letters

Volumn 2, Issue 4, 2000, Pages 507-510

  Rodríguez, Abimael D ^a   Ramírez, Catherine ^a  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

Author keywords

[No Author keywords available]

Indexed keywords

BRIDGED COMPOUND; COLOMBIASIN A; TUBERCULOSTATIC AGENT;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COELENTERATE; DRUG EFFECT; MICROBIOLOGICAL EXAMINATION; MYCOBACTERIUM TUBERCULOSIS; SPECTROSCOPY;

ANIMALS; ANTITUBERCULAR AGENTS; BRIDGED COMPOUNDS; CNIDARIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; SPECTRUM ANALYSIS;

EID: 0034707988     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol991362i     Document Type: Article

References (15)

1. Rodríguez, A. D. Tetrahedron 1995, 51, 4571-4618 and references therein.
2. For previous research on the chemistry of P. elisabethae, see: (a) Schmitz, F. J.; Campbell, D. C.; Kubo, I. Steroids 1976, 28, 211-221.
3. (b) Look, S. A.; Fenical, W.; Matsumoto, G. K.; Clardy, J. J. Org. Chem. 1986, 51, 5140-5145.
4. (c) Fenical, W. J. Nat. Prod. 1987, 50, 1001-1008.
5. (d) Harvis, C. A.; Burch, M. T.; Fenical, W. Tetrahedron Lett. 1988, 29, 4361-4364.
6. (e) Roussis, V.; Wu, Z.; Fenical, W.; Strobel, S. A.; Van Duyne, G. D.; Clardy, J. J. Org. Chem. 1990, 55, 4916-4922.
7. Rodríguez, A. D.; Ramírez, C.; Rodríguez, I. I.; González, E. Org. Lett. 1999, 1, 527-530.
8. Taken in part from the Ph.D. Dissertation of C. Ramírez, University of Puerto Rico, in preparation.
9. 7).
10. Rodríguez, A. D.; González, E.; Huang, S. D. J. Org. Chem. 1998, 63, 7083-7091.
11. 1H COSY spectrum of 1 revealed no coupling between H-9 and H-10, we firmly established their connectivity on the basis of a strong HMBC correlation between H-10 (δ 5.68) and C-9 (δ 38.7).
12. (a) Rodríguez, A.D.; Ramírez, C.; Rodríguez, I. I. Tetrahedron Lett. 1999, 40, 7627-7631.
13. (b) Rodríguez, A. D.; Ramírez, C.; Rodríguez, I. I. J. Nat. Prod. 1999, 62, 997-999.
14. (c) Rodríguez, A. D.; Ramírez, C.; Rodríguez, I. I.; Barnes, C. L. J. Org. Chem. 2000, 65, in press.
15. The absolute stereochemistry of elisabethin A (2) is not known.