Murine model study of the practical implication of trypanosome-induced immunosuppression in vaccine-based disease control programmes

Veterinary Immunology and Immunopathology

Volumn 74, Issue 3-4, 2000, Pages 271-284

  Onah, Denis Nnabuike ^a   Wakelin, Derek ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Immunosuppression; Mouse; Trichinella spiralis; Trypanosoma brucei; Vaccination

Indexed keywords

CONCANAVALIN A; GAMMA INTERFERON; IMMUNOGLOBULIN G1; INTERLEUKIN 5; PROTOZOAL VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EOSINOPHILIA; ERYTHROCYTE VOLUME; FEMALE; IMMUNE DEFICIENCY; LEUKOCYTE DIFFERENTIAL COUNT; MESENTERY LYMPH NODE; MONOCYTOSIS; MOUSE; NONHUMAN; PARASITEMIA; SPLEEN CELL; TRICHINELLA SPIRALIS; TRICHINOSIS; TRYPANOSOMA BRUCEI; TRYPANOSOMIASIS; VACCINATION;

ANIMALS; ANTIBODIES, HELMINTH; ANTIGENS, HELMINTH; CONCANAVALIN A; CYTOKINES; EOSINOPHILS; FEMALE; HEMATOCRIT; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; MICE; MODELS, IMMUNOLOGICAL; MONOCYTES; PARASITEMIA; PROTOZOAN VACCINES; TRICHINELLA; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

ANIMALIA; MURINAE; TRICHINELLA SPIRALIS; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0034705137     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2427(00)00177-X     Document Type: Article

References (21)

1. Askonas B.A. Macrophages as mediators of immunosuppression in murine African trypanosomiasis. Curr. Top. Microbiol. Immunol. 117:1985;119-127.
2. Bakhiet M., Buscher P., Harris R.A., Kristensson K., Wigzell H., Olsson T. Different trypanozoon species possess CD8 dependent lymphocyte triggering factor-like activity. Immunol. Lett. 50:1996;71-80.
3. Bancroft G.J., Sutton C.J., Morris A.G., Askonas B.A. Production of interferons during experimental African trypanosomiasis. Clin. Exp. Immunol. 52:1983;135-143.
4. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
5. Fakae B.B., Chiejina S.N. The prevalence of concurrent trypanosome and gastrointestinal nematode infections in west African dwarf sheep and goats in Nsukka area of eastern Nigeria. Vet. Parasitol. 49:1993;313-318.
6. Goossens B., Osaer S., Kora S., Jaitner J., Ndao M., Geerts S. The interaction of Trypanosoma congolense and Haemonchus contortus in Djallonke sheep. Int. J. Parasitol. 27:1997;1579-1584.
7. Goyal P.K., Bolas-Fernandez F., Wakelin D. Immunisation of mice against Trichinella spiralis and T. britovi using excretory and secretary antigens. J. Helminthol. 71:1997;109-112.
8. Goyal P.K., Hermanek J., Wakelin D. Lymphocyte proliferation and cytokine production in mice infected with different geographical isolates of Trichinella spiralis. Parasite Immunol. 16:1994;105-110.
9. Hermanek J., Goyal P.K., Wakelin D. Lymphocyte, antibody and cytokine responses during concurrent infections between helminths that selectively promote T-helper-1 or T-helper-2 activity. Parasite Immunol. 16:1994;111-117.
10. Ilemobade A.A., Adegboye D.S., Onoviran O., Chima J.C. Immunosuppressive effects of trypanosomal infection in cattle immunised against contagious bovine pleuropnemonia. Parasite Immunol. 4:1982;273-282.
11. Ishikawa N., Wakelin D., Mahida Y.R. Role of T helper 2 cells in intestinal goblet cell hyperplasia in mice infected with Trichinella spiralis. Gastroenterology. 113:1997;542-549.
12. Kaufmann J., Dwinger R.H., Hallebeek A., van Dijk B., Pfister K. The interaction of Trypanosoma congolense and Haemonchus contortus infections in trypanotolerant N'dama cattle. Vet. Parasitol. 43:1997;157-170.
13. Onah D.N., Wakelin D. Trypanosome-induced suppression of responses to Trichinella spiralis in vaccinated mice. Int. J. Parasitol. 29:1999;1017-1026.
14. Phillips R.S., Selby G.R., Wakelin D. The effect of Plasmodium berghei and Trypanosoma brucei infections on the immune expulsion of the nematode Trichuris muris from mice. Int. J. Parasitol. 4:1974;409-418.
15. Pond L., Wassom D.L., Hayes C.E. Evidence for differential induction of helper T cell subsets during Trichinella spiralis infection. J. Immunol. 143:1989;4232-4237.
16. Robinson K., Bellaby T., Wakelin D. Immune response profiles in vaccinated and non-vaccinated high- and low-responder mice during infection with the intestinal nematode Trichinella spiralis. Parasitology. 110:1995;71-78.
17. Scott J.M., Pegram R.G., Holmes P.H., Pays T.W.F., Knight P.A., Jennings F.W., Urquhart G.M. Immunosuppression in bovine trypanosomiasis: field studies using foot-and-mouth disease vaccine and clostridial vaccine. Trop. Anim. Health Prod. 9:1977;159-165.
18. Sileghem, M., Flynn, J.N., Darji, A., DeBaetselier, P., Naessens, J., 1994. African trypanosomiasis. In: Kierszenbaum, F. (Ed.), Parasitic Infections and the Immune System. Academic Press, San Diego, pp. 1-51.
19. Urquhart G.M., Murray M., Murray P.K., Jennings F.W., Bate E. Immunosuppression in Trypanosoma brucei infections in rats and mice. Trans. R. Soc. Trop. Med. Hyg. 67:1973;528-535.
20. Wakelin D., Lloyd M. Immunity to primary and challenge infections of Trichinella spiralis in mice: a re-examination of conventional parameters. Parasitology. 72:1976;173-183.
21. Wakelin D., Wilson M.M. T and B cells in the transfer of immunity against Trichinella spiralis in mice. Immunology. 37:1979;103-109.