A common mutation in lipoprotein lipase confers a 2-fold increase in risk of ischemic cerebrovascular disease in women but not in men

Circulation

Volumn 101, Issue 20, 2000, Pages 2393-2397

  Wittrup, Hans H ^a   Nordestgaard, Børge G ^a,b   Sillesen, Henrik ^c   Schnohr, Peter ^b   Tybjærg Hansen, Anne ^a,b,d  

^a GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^b BISPEBJERG HOSPITAL   (Denmark)

^c GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^d Rigshospitalet   (Denmark)

Author keywords

Cerebral ischemia; Cholesterol; Genetics; Polymorphism (genetic); Triglycerides

Indexed keywords

ASPARAGINE; LIPOPROTEIN LIPASE; SERINE; TRIACYLGLYCEROL;

ADULT; ARTICLE; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SEX DIFFERENCE;

EID: 0034705084     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.101.20.2393     Document Type: Article

References (14)

1. Hokanson JE, Austin MA. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk. 1996;3:211-219.
2. Lindenstrom E, Boysen G, Nyboe J. Influence of total cholesterol, high density lipoprotein cholesterol, and triglycerides on risk of cerebrovascular disease: the Copenhagen City Heart Study [published erratum appears in BMJ. 1994;309:1619]. BMJ. 1994;309:11-15.
3. Brunzell J. Familial lipoprotein lipase deficiency and other causes of the chylomicronemia syndrome. In Scriver C, Beaudet A, Sly W, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease. 7th ed. New York: McGraw-Hill; 1995:1913-1932.
4. Wittrup HH, Tybjaerg-Hansen A, Abildgaard S, Steffensen R, Schnohr P, Nordestgaard BG. A common substitution (Asn291Ser) in lipoprotein lipase is associated with increased risk of ischemic heart disease. J Clin Invest. 1997;99:1606-1613.
5. Agerholm-Larsen B, Tybjærg-Hansen A, Frikke-Schmidt R, Grønholdt M-LM, Jensen G, Nordestgaard BG. ACE gene polymorphism as a risk factor for ischemic cerebrovascular disease. Ann Intern Med. 1997;127:346-355.
6. Wittrup HH, Tybjaerg-Hansen A. Nordestgaard BG. Lipoprotein lipase mutations, plasma lipids, and lipoproteins and risk of ischemic heart disease: a meta-analysis. Circulation. 1999;99:2901-2907.
7. Nordestgaard BG, Wootton R, Lewis B. Selective retention of VLDL, IDL, and LDL in the arterial intima of genetically hyperlipidemic rabbits in vivo: molecular size as a determinant of fractional loss from the intima-inner media. Arterioscler Thromb Vasc Biol. 1995;15:534-542.
8. Goldberg IJ. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J Lipid Res. 1996;37:693-707.
9. Benavente O, Hart RG, Sherman DG. Primary prevention of transient ischemic attack and thromboembolic stroke. In Verstraete M, Fuster V, Opol EJ, eds. Cardiovascular Thrombosis: Thrombocardiology and Thromboneurology. Philadelphia: Lippincott-Raven; 1998:585-595.
10. Gariballa SE, Parker SG, Taub N, Castleden M. Nutritional status of hospitalized acute stroke patients. Br J Nutr. 1998;79:481-487.
11. Breier C, Mhlberger V, Drexel H, Herold M, Lisch HJ, Knapp E, Braunsteiner H. Essential role of post-heparin lipoprotein lipase activity and of plasma testosterone in coronary artery disease. Lancet. 1985;1:1242-1244.
12. Sorva R, Kuusi T, Taskinen MR, Perheentupa J, Nikkilä EA. Testosterone substitution increases the activity of lipoprotein lipase and hepatic lipase in hypogonadal males. Atherosclerosis. 1988;69:191-197.
13. Iverius PH, Brunzell JD. Relationship between lipoprotein lipase activity and plasma sex steroid level in obese women. J Clin Invest. 1988;82: 1106-1112.
14. Price TM, O'Brien SN, Welter BH, George R, Anandjiwala J, Kilgore M. Estrogen regulation of adipose tissue lipoprotein lipase: possible mechanism of body fat distribution. Am J Obstet Gynecol. 1998;178:101-107.