Effect of ligand binding on the flexibility of dihydrofolate reductase as revealed by compressibility

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1478, Issue 2, 2000, Pages 257-266

  Kamiyama, Tadashi ^a   Gekko, Kunihiko ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Accessible surface area; Cavity; Compressibility; Dihydrofolate reductase; Ligand; X ray crystal structure

Indexed keywords

DIHYDROFOLATE REDUCTASE; DIHYDROFOLIC ACID; METHOTREXATE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; POTASSIUM CHLORIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TETRAHYDROFOLIC ACID;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ESCHERICHIA COLI; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI; LIGANDS; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; SURFACE PROPERTIES; TETRAHYDROFOLATE DEHYDROGENASE; X-RAY DIFFRACTION;

ESCHERICHIA COLI;

EID: 0034704984     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(00)00019-4     Document Type: Article

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