Mutation analysis of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia

Neuroscience Letters

Volumn 296, Issue 2-3, 2000, Pages 168-170

  Sakurai, Kaoru ^a   Toru, Michio ^b   Yamakawa Kobayashi, Kimiko ^a   Arinami, Tadao ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Association; Genome; Mutation; N methyl D aspartate receptor NR1 subunit gene; Schizophrenia

Indexed keywords

IONOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHENCYCLIDINE; RECEPTOR SUBUNIT;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC CODE; GENETIC SCREENING; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; JAPAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SCHIZOPHRENIA;

ADULT; ALLELES; BRAIN; BRAIN CHEMISTRY; DNA MUTATIONAL ANALYSIS; FEMALE; GENETIC SCREENING; GENOTYPE; GLUTAMIC ACID; HUMANS; MALE; MIDDLE AGED; MUTATION; NEURONS; POLYMORPHISM, GENETIC; RECEPTORS, N-METHYL-D-ASPARTATE; SCHIZOPHRENIA;

EID: 0034704380     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01599-8     Document Type: Article

References (22)

1. The NMDA antagonist model for schizophrenia: Promise and pitfalls
2. Investigation of polymorphism in the NMDAR1 gene in association with schizophrenia (presented at the 49th annual meeting of the American Society of Human Genetics
3. Characterization of single-nucleotide polymorphisms in coding regions of human genes
4. Current methods of mutation detection
5. Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A
6. Update on chromosomal locations for psychiatric disorders: Report of the interim meeting of chromosome workshop chairpersons from the VIIth World Congress of Psychiatric Genetics, Monterey, CA, October 14-18, 1999
7. Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene
8. The N-methyl-D-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias
9. Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death
10. Reduced spontaneous activity of mice defective in the epsilon 4 subunit of the NMDA receptor channel
11. Recent advances in the phencyclidine model of schizophrenia
12. Molecular diversity of the NMDA receptor channel
13. Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice
14. Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice
15. Study of a new schizophrenomimetic drug, Sernyl
16. Ketamine-induced exacerbation of psychotic symptoms and cognitive impairment in neuroleptic-free schizophrenics
17. Role of NMDA receptor polymorphisms in the pathogenesis of schizophrenia (presented at the eight World Congress on Psychiatric Genetics)
18. Heteromeric NMDA receptors: Molecular and functional distinction of subtypes
19. Glutamate receptors: Brain function and signal transduction
20. Nucleotide sequence diversity in human NMDA receptor genes (presented at the eighth World Congress on Psychiatric Genetics)
21. Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit
22. Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1)