Intra-cerebellar infusion of NMDA receptor antagonist AP5 disrupts classical eyeblink conditioning in rabbits

Brain Research

Volumn 887, Issue 1, 2000, Pages 144-156

  Chen, Gengxin ^a   Steinmetz, Joseph E ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

Cerebellar cortex; Interpositus nucleus; Learning and memory; Plasticity; Response timing

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONDITIONED REFLEX; CONDITIONING; CONTROLLED STUDY; DRUG EFFECT; EYELID REFLEX; HISTOLOGY; LEARNING; MALE; MEMORY; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; RESPONSE TIME;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; CEREBELLUM; CONDITIONING, EYELID; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MICROINJECTIONS; RABBITS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0034704267     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)03005-5     Document Type: Article

References (45)

1. Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats
2. Cerebellar cortical AMPA-kainate receptor blockade prevents performance of classically conditioned nictitating membrane responses
3. Excitatory synaptic potentials in neurons of the deep nuclei in olivo-cerebellar slice cultures
4. Responses to excitatory amino acids of Purkinje cells and neurones of the deep nuclei in cerebellar slice cultures
5. A synaptic model of memory: Long-term potentiation in the hippocampus
6. Microinjections of anisomycin into the intermediate cerebellum during learning affect the acquisition of classically conditioned responses in the rabbit
7. Intra-amygdala infusion of the N-methyl-D-aspartate receptor antagonist AP5 impairs acquisition but not performance of discriminated approach to an appetitive CS
8. Detailed behavioral analysis of water maze acquisition under APV or CNQX: Contribution of sensorimotor disturbances to drug-induced acquisition deficits
9. Intra-amygdala infusion of the N-methyl-D-aspartate receptor antagonist AP5 blocks acquisition but not expression of fear-potentiated startle to an auditory conditioned stimulus
10. Spatial memory and N-methyl-D-aspartate receptor antagonists APV and MK-801: Memory impairments depends on familiarity with the environment, drug dose, and training duration
11. Effects of lidocaine injection in the interpositus nucleus and red nucleus on conditioned behavioral and neuronal responses
12. Impaired classical eyeblink conditioning in cerebellar-lesioned and Purkinje cell degeneration (pcd) mutant mice
13. Microinfusion of protein kinase inhibitor H7 into the cerebellum impairs the acquisition but not the retention of classical eyeblink conditioning in rabbits
14. Intra-cerebellar infusion of NMDA receptor antagonist AP5 disrupts classical eyeblink conditioning in rabbits
15. Reversible lesions of the cerebellar interpositus nucleus during acquisition and retention of a classical conditioned behavior
16. Acquisition of contextual Pavlovian fear conditioning is blocked by application of an NMDA receptor antagonist D,L-2-amino-5-phosphonovaleric acid to the basolateral amygdala
17. Learning induces a CDC2-related protein kinase, KKIAMRE
18. N-methyl-D-aspartate receptor antagonists reduce synaptic excitation in the hippocampus
19. Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors
20. Taste-potentiated odor conditioning: Impairment produced by infusion of an N-methyl-D-aspartate receptor antagonist into basolateral amygdala
21. Frequency-dependent involvement of NMDA receptors in the hippocampus: A novel synaptic mechanism
22. Amnesia by post-training infusion of glutamate receptor antagonists into the amygdala, hippocampus, and entorhinal cortex
23. N-methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning
24. Cerebellar circuits and synaptic mechanisms involved in classical eyeblink conditioning
25. Effects of intra-amygdala injections of NMDA receptor antagonists on acquisition and retention of inhibitory avoidance
26. Conditioned eyeblink response is impaired in mutant mice lacking NMDA receptor subunit NR2A
27. Localization of a memory trace in the mammalian brain
28. Pre- and post-training infusion of N-methyl-D-aspartate receptor antagonists into the amygdala impair memory in an inhibitory avoidance task
29. Memory deficits induced by γ-L-glutamyl-L-aspartate and D-2-amino-5-phosphonovalerate in a Y-maze avoidance task: Relationship to NMDA receptor antagonism
30. Roles of cerebellar cortex and nuclei in motor learning: Contradictions or clues?
31. Cerebellum: Essential involvement in the classically conditioned eyelid response
32. Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala
33. Synaptic plasticity and learning II: Do different kinds of plasticity underlie different kinds of learning?
34. The current excitement in long-term potentiation
35. Lidocaine infusion in a critical region of cerebellum completely prevents learning of the conditioned eyeblink response
36. MK801 retards acquisition of a classically conditioned response without affecting conditioning-related alterations in perforant path-granule cell synaptic transmission
37. The NMDA antagonist memantine impairs classical eyeblink conditioning in humans
38. Early acquisition, but not retention, of the classically conditioned eyeblink response is N-methyl-D-aspartate (NMDA) receptor dependent
39. Brain substrates of classical eyeblink conditioning: A highly localized but also distributed system
40. Disruption of classical eyelid conditioning after cerebellar lesions: Damage to a memory trace system or a simple performance deficit?
41. N-methyl-D-aspartate receptors in associative eyeblink conditioning: Both MK-801 and phencyclidine produce task- and dose-dependent impairments
42. A system for quantitative analysis of associative learning. Part 1. Hardware interfaces with cross-species applications
43. Intrahippocampal administration of both the D- and the L-isomers of AP5 disrupt spontaneous alternation behavior and evoked potentials
44. Distinct spatiotemporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellum