Influence of codon usage on the immunogenicity of a DNA vaccine against tetanus

Vaccine

Volumn 19, Issue 7-8, 2000, Pages 810-815

  Stratford, Richard ^a   Douce, Gillian ^a   Zhang Barber, Li ^a   Fairweather, Neil ^a   Eskola, Juhani ^a   Dougan, Gordon ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Codon usage; DNA vaccines; Murine model; Tetanus

Indexed keywords

DNA VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; CODON; CONTROLLED STUDY; IMMUNIZATION; IMMUNOGENICITY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TETANUS; VACCINATION;

ANIMALS; BASE SEQUENCE; CLOSTRIDIUM TETANI; CODON; COS CELLS; CPG ISLANDS; DNA PRIMERS; FEMALE; GENE EXPRESSION; GENES, BACTERIAL; IMMUNIZATION; INJECTIONS, INTRAMUSCULAR; MICE; MICE, INBRED BALB C; PEPTIDE FRAGMENTS; PLASMIDS; TETANUS ANTITOXIN; TETANUS TOXIN; TETANUS TOXOID; TRANSFECTION; VACCINES, DNA;

EID: 0034703847     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(00)00246-2     Document Type: Article

References (13)

1. DNA vaccines
2. The role of CpG dinucleotides in DNA vaccines
3. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
4. Manipulation of pathogen-derived genes to influence antigen presentation via DNA vaccines
5. Preferential codon usage in prokaryotic genes: the optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genes
6. Expression of tetanus toxin fragment C in E. coli: high level expression by removing rare codons
7. High-level expression of tetanus toxin fragment C in Pichia pastoris strains containing multiple tandem integrations of the gene
8. Increased immune response elicited by DNA vaccination with a synthetic gp 120 sequence with optimized codon usage
9. Optimization of codon usage of plasmid DNA vaccine is required for the effective MHC class I restricted T cell responses against an intracellular bacterium
10. Codon optimization effect on translational efficiency of DNA vaccinein mammalian cells: analysis of plasmid DNA encoding a CTL epitope derived from microorganisms
11. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs