Impaired angiogenic balance and suppression of tumorigenicity in HeLa cells chronically exposed to interferon-α

Biochemical and Biophysical Research Communications

Volumn 277, Issue 2, 2000, Pages 410-416

  Lopez Ocejo O ^a   Perea, S E ^a   Bequet Romero, M ^a   Araa, M J ^a   Lopez Saura P ^a  

^a CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Cuba)

Author keywords

Angiogenesis; bFGF; HPV; Interferon; Tumorigenicity; VEGF

Indexed keywords

ALPHA INTERFERON; BASIC FIBROBLAST GROWTH FACTOR; MESSENGER RNA; RECOMBINANT ALPHA2B INTERFERON; VASCULOTROPIN; VIRUS DNA;

ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TUMOR CELL; VIRUS CARCINOGENESIS; WART VIRUS;

HUMAN PAPILLOMAVIRUS TYPES; MUS MUSCULUS;

EID: 0034703613     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.3690     Document Type: Article

References (41)

1. Oncogenic association of specific human papillomavirus types with cervical neoplasia
2. Cellular transformation by papillomavirus oncoproteins
3. Viruses in human cancer
4. Human papillomavirus type 16 transformation of primary human embryonic fibroblasts requires expression of open reading frames E6 and E7
5. Oncogenes result in genomic alterations that activate a transcriptionally silent, dominantly selectable reporter gene (neo)
6. Induction of chromosome abnormalities in mouse and human epidermal keratinocytes by the human papillomavirus type 16 E7 oncogene
7. Papillomaviruses in anogenital cancer as a model to understand the role of viruses in human cancers
8. HPV-16 E6-E7 differential transcription induced in SiHa cervical cancer cell line by interferons
9. Selective suppression of human papilloma virus type 18 mRNA level in HeLa cells by interferon
10. Interferon-alpha elicits downregulation of human papillomavirus 18 mRNA in HeLa cells by selective repression of endogenous viral transcription
11. The action of interferons on virus-associated human neoplasms
12. Pathogenesis and treatment of human genital papillomavirus infections: A review
13. Interferon therapy in juvenile laryngeal papillomatosis
14. 13-cis-Retinoic acid plus interferon alpha-2a: Highly active systemic therapy for squamous cell carcinoma of the cervix
15. Modulation of human papillomavirus type 16 mRNA in cervical invasive carcinoma patients by interferon-alpha therapy
16. Partial phenotypic reversion of HeLa cells by long-term interferon-alpha treatment
17. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
18. 51
19. Differentiation in mouse leukemia cells mediated by an immune interferon preparation
20. Human interferon and cell growth inhibition. VII. Reversibility of interferon activities
21. Interferon induces morphologic reversion with elimination of extrachromosomal viral genomes in bovine papillomavirus-transformed mouse cells
22. Development of transformed phenotype induced by a human ras oncogene is inhibited by interferon
23. Reorganization of the cytoskeleton by interferon in MSV-transformed cells
24. Effects of interferons alpha, beta, gamma alone or in combination on the phenotype of human colon carcinoma cells
25. Inhibition of the transformed phenotype of carcinoma cells that contain human papillomavirus
26. Oncogenicity of human papillomavirus- or adenovirus-transformed cells correlates with resistance to lysis by natural killer cells
27. Introduction of human chromosome 11 via microcell transfer controls tumorigenic expression of HeLa cells
28. Normal human chromosome 11 suppresses tumorigenicity of human cervical tumor cell line SiHa
29. The 55 kDa regulatory subunit of protein phosphatase 2A plays a role in the activation of the HPV16 long control region in human cells with a deletion in the short arm of chromosome 11
30. Protein phosphatase 2A and the regulation of human papillomavirus gene activity
31. Suppression in vivo of human papillomavirus type 18 E6-E7 gene expression in nontumorigenic HeLa X fibroblast hybrid cells
32. Synergistic effect of retinoids and interferon alpha on tumor-induced angiogenesis: Anti-angiogenic effect on HPV-harboring tumor-cell lines
33. Interferons alpha and beta downregulate the expression of basic fibroblast growth factor in human carcinomas
34. Inhibition of basic fibroblast growth factor expression, angiogenesis, and growth of human bladder carcinoma in mice by systemic interferon-alpha administration
35. Interleukin 6 induces the expression of vascular endothelial growth factor
36. Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays
37. Angiogenesis-regulating cytokines: Activities and interactions
38. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium
39. Juvenile hemangioma of the testis: Analysis of expression of angiogenic factors
40. Inhibition of angiogenesis