Estrogen, progestogen and tamoxifen increase synaptic density of the hippocampus of ovariectomized rats

Neuroscience Letters

Volumn 291, Issue 3, 2000, Pages 183-186

  Silva, Ivaldo ^a   Mello, Luiz E A M ^a   Freymüller, Edna ^a   Haidar, Mauro A ^a   Baracat, Edmund C ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Estrogen; Progestogen; Stratum radiatum; Synaptic density; Tamoxifen, CA1 hippocampus

Indexed keywords

CONJUGATED ESTROGEN; CONJUGATED ESTROGEN PLUS MEDROXYPROGESTERONE ACETATE; MEDROXYPROGESTERONE; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; COGNITION; CONTROLLED STUDY; DENSITY; ELECTRON MICROSCOPY; FEMALE; HIPPOCAMPUS; HORMONE SUBSTITUTION; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT; SHORT SURVEY; SYNAPSE;

EID: 0034703599     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01410-5     Document Type: Article

References (26)

1. Bartus R.T., Dean R.L., Beer B., Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science. 217:1982;408-417.
2. Cruz-Orive L.M. Particle number can be estimated using a dissector of unknown thickness - the selector. J. Microsc. 145:1987;121-142.
3. Gould E., Woolley C.S., Frankfurt M., McEwen B.S. Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood. J. Neurosci. 10:1990;1286-1291.
4. Grainger D.J., Metcalfe J.C. Tamoxifen: teaching an old drug new tricks? Nat. Med. 2:1996;381-385.
5. Hammond C.B. Menopause and hormone replacement therapy: an overview. Obstet. Gynecol. 87:1996;S2-S15.
6. Haskell S.G., Richardson E.D., Horwitz R.I. The effect of estrogen replacement therapy on cognitive function in women: a critical review of the literature. J. Clin. Epidemiol. 50:1997;1249-1264.
7. Holzbauer M. Physiological aspects of steroids with anesthetic properties. Med. Biol. 54:1976;227-242.
8. Holzbauer M., Youdim M.B.H. Estrous-cycle and monoamine-oxidase activity. Br. J. Pharmacol. 48:1973;600-608.
9. Jordan V.C. Designer estrogens. Sci. Am. 279:1998;60-67.
10. Kedar R.P., Bourne T.H., T J., P ., Collins W.P., Ashley S.E., Cosgrove D.O., Campbell S. Effects of tamoxifen on uterus and ovaries of postmenopausal women in a randomized breast-cancer prevention trial. Lancet. 343:1994;1318-1321.
11. Koelle G., Friedenwald J. A histochemical method for localizing cholinesterase activity. Proc. Soc. Exp. Biol. Med. 70:1949;617-622.
12. Lewis P.R., Shute C.C.D. Electron-microscopic distribution of cholinesterase in cholinergic neurones. J. Anat. 99:1965;941-952.
13. Luine V.N., McEwen B.S. Effects of estradiol on turnover of type-A monoamine-oxidase in brain. J. Neurochem. 28:1977;1221-1227.
14. MacGregor J.I., Jordan V.C. Basic guide to the mechanisms of antiestrogen action. Pharmacol. Rev. 50:1998;151-196.
15. McKenna S.E., Simon N.G., Cologer-Clifford A. An assessment of agonist/antagonist effects of tamoxifen in the female mouse brain. Horm. Behav. 26:1992;536-544.
16. Merryman W., Boiman R., Barnes K., Rothchild I. Progesterone 'anesthesia' in human subjects. J. Clin. Endocrinol. Metab. 14:1954;1567-1569.
17. Murphy D.D., Segal M. Regulation of dendritic spine density in cultured rat hippocampal neurons by steroid hormones. J. Neurosci. 16:1996;4059-4068.
18. Pfaff D.W. Estrogen and Brain Function. 1980;Springer-Verlag, New York.
19. Sherwin B.B. Hormones, mood, and cognitive functioning in postmenopausal women. Obstet. Gynecol. 87:1996;S20-S26.
20. Weiland N.G. Glutamic acid decarboxylase messenger ribonucleic acid is regulated by estradiol and progesterone in the hippocampus. Endocrinology. 131:1992;2697-2702.
21. Weiland N.G., Orchinik M. Specific subunit mRNAs of the GABAa receptor are regulated by progesterone in subfields of the hippocampus. Mol. Brain Res. 32:1995;271-278.
22. Woolley C.S., McEwen B.S. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J. Neurosci. 12:1992;2549-2554.
23. Woolley C.S., McEwen B.S. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J. Comp. Neurol. 336:1993;293-306.
24. Woolley C.S., Weiland N.G., McEwen B.S., Schwartzkroin P.A. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J. Neurosci. 17:1997;1848-1859.
25. Wu X., Glinn M.A., Ostrowski N.L., Su Y.A., Ni B.H., Cole H.W., Bryant H.U., Paul S.M. Raloxifene and estradiol benzoate both fully restore hippocampal choline acetyltransferase activity in ovariectomized rats. Brain Res. 847:1999;98-104.
26. Yaffe K., Sawaya G., Lieberburg I., Grady D. Estrogen therapy in postmenopausal women. Effects on cognitive function and dementia. J. Am. Med. Assoc. 279:1998;688-695.