Blockade of adhesion of sickle cells to endothelium by monoclonal antibodies

New England Journal of Medicine

Volumn 342, Issue 25, 2000, Pages 1910-1912

  Hebbel, Robert P ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY;

ARTICLE; BLOOD VESSEL OCCLUSION; CELL ADHESION; CELL INTERACTION; ENDOTHELIUM CELL; HUMAN; IMMUNOTHERAPY; NONHUMAN; PRIORITY JOURNAL; SICKLE CELL; SICKLE CELL ANEMIA;

ANEMIA, SICKLE CELL; ANTIBODIES, MONOCLONAL; CELL ADHESION; ENDOTHELIUM, VASCULAR; ERYTHROCYTES, ABNORMAL; HEMOGLOBIN, SICKLE; HUMANS;

EID: 0034702195     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200006223422512     Document Type: Article

References (5)

1. Embury SH, Hebbel RP, Steinberg MH, Mohandas N. Pathogenesis of vasoocclusion. In: Embury SH, Hebbel RP, Steinberg MH, Mohandas N, eds. Sickle cell disease: basic principles and clinical practice. New York: Raven Press, 1994:311-26.
2. Hebbel RP. Adhesive interactions of sickle erythrocytes with endothelium. J Clin Invest 1997;99:2561-4.
3. Kaul DK, Fabry ME, Nagel RL. Erythrocytic and vascular factors influencing the microcirculatory behavior of blood in sickle cell anemia. Ann N Y Acad Sci 1989;565:316-26.
4. Hebbel RP, Vercellotti GM. The endothelial biology of sickle cell disease. J Lab Clin Med 1997;129:288-93.
5. Kaul DK, Tsai HM, Liu XD, Nakada MT, Nagel RL, Coller BS. Monoclonal antibodies to αvβ3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor. Blood 2000; 95:368-74.