Two actions of frabin: Direct activation of Cdc42 and indirect activation of Rac

Oncogene

Volumn 19, Issue 27, 2000, Pages 3050-3058

  Ono, Yuichi ^a,c   Nakanishi, Hiroyuki ^a,b   Nishimura, Miyuki ^a,c   Kakizaki, Mayumi ^a,c   Takahashi, Kenichi ^a   Miyahara, Masako ^a   Satoh Horikawa, Keiko ^a,c   Mandai, Kenji ^a,b   Takai, Yoshimi ^a,b  

^a JCR Pharmaceuticals Co Ltd   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KAN Research Institute Inc ^*  (Japan)

Author keywords

Cdc42; Filopodia; Frabin; Lamellipodia; Membrane ruffles; Rac

Indexed keywords

ACTIN; ADENOSINE TRIPHOSPHATE; BINDING PROTEIN; CELL CYCLE PROTEIN; CYSTEINE; FABIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE DIPHOSPHATE; PLECKSTRIN; RAC PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CELL LINE; CELL STRUCTURE; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; FIBROBLAST; LAMELLIPODIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE HOMOLOGY;

EID: 0034702173     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1203631     Document Type: Article

References (21)

1. Cerione RA and Zheng Y. (1996). Curr. Opin. Cell Biol., 8, 216-222.
2. Gluven JA. Whitehead I, Bagrodia S, Kay R and Cerione RA. (1999). J. Biol. Chem., 274, 2279-2285.
3. Habets GG, Scholtes EH, Zuydgeest D, van der Kammen RA, Stam JC, Berns A and Collard JG. (1994). Cell, 77, 537-549.
4. Hall A. (1998). Science, 279, 509-514.
5. Komuro R, Sasaki T, Takaishi K, Orita S and Takai Y. (1996). Genes Cells, 1, 943-951.
6. Kozma R, Ahmed S, Best A and Lim L. (1995). Mol. Cell. Biol., 15, 1942-1952.
7. Michiels F, Stam JC, Hordijk PL, van der Kammen RA, Ruuls-Van Stalle L, Feltkamp CA and Collard JG. (1997). J. Cell Biol., 137, 387-398.
8. Miki H, Sasaki T, Takai Y and Takenawa T. (1998). Nature, 391, 93-96.
9. Nagata K, Driessens M, Lamarche N, Gorski JL and Hall A. (1998). J. Biol. Chem., 273, 15453-15457.
10. Nobes CD and Hall A. (1995). Cell, 81, 53-62.
11. Obaishi H, Nakanishi H, Mandai K, Satoh K, Satoh A, Takahashi K, Miyahara M, Nishioka H, Takaishi K and Takai Y. (1998). J. Biol. Chem., 273, 18697-18700.
12. Onishi M, Kinoshita S, Morikawa Y, Shibuya A, Phillips J, Lanier LL, Gorman DM, Nolan GP, Miyajima A and Kitamura T. (1996). Exp. Hematol., 24, 324-329.
13. Pasteris NG, Cadle A, Logie LJ, Porteous MEM, Schwartz CE, Stevenson RE, Glover TW, Wilroy RS and Gorski JL. (1994). Cell, 79, 669-678.
14. Stam JC, Sander EE, Michiels F, van Leeuwen FN, Kain HE, van der Kammen RA and Collard JG. (1997). J. Biol. Chem., 272, 28447-28454.
15. Symons M. (1996). Trends. Biochem. Sci., 21, 178-181.
16. Takahashi K, Nakanishi H, Miyahara M, Mandai K, Satoh K, Saloh A, Nishioka H, Aoki J, Nomoto A, Mizoguchi A and Takai Y. (1999). J. Cell Biol., 145, 539-549.
17. Takai Y, Sasaki T, Tanaka K and Nakanishi H. (1995). Trends. Biochem. Sci., 20, 227-231.
18. Umikawa M, Obaishi H, Nakanishi H, Satoh-Horikawa K, Takahashi K, Hotta I, Matsuura Y and Takai Y. (1999). J. Biol. Chem., 274, 25197-25200.
19. Whitehead I, Kirk H, Tognon C, Trigo-Gonzalez G and Kay R. (1995). J. Biol. Chcm., 270, 18388-18395.
20. Zheng Y, Fischer D, Santos MF, Tigri G, Pasteris NG, Gorski JL and Xu Y. (1996a). J. Biol. Chem., 271, 33169-33172.
21. Zheng Y, Zangrilli D, Cerione RA and Eva A. (1996b). J. Biol. Chem., 271, 19017-19020.