The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a

Human Molecular Genetics

Volumn 9, Issue 5, 2000, Pages 821-828

  Jones, Julie M ^a   Huang, Jian Dong ^b,c   Mermall, Valerie ^d   Hamilton, Bruce A ^e   Mooseker, Mark S ^d   Escayg, Andrew ^a   Copeland, Neal G ^b   Jenkins, Nancy A ^b   Meisler, Miriam H ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d YALE UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; MUTANT PROTEIN; MYOSIN;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; EXON; GENE EXPRESSION; GENE MAPPING; INTRACELLULAR TRANSPORT; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PURKINJE CELL; SMOOTH ENDOPLASMIC RETICULUM;

ANIMALIA; MAMMALIA;

EID: 0034701252     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/9.5.821     Document Type: Article

References (30)

1. Cheney, R.E., O'Shea, M.K., Heuser, J.E., Coelho, M.V., Wolenski, J.S., Espreafico, E.M., Forscher, P., Larson, R.E. and Mooseker, M.S. (1993) Brain Myosin-V is a two-headed unconventional myosin with motor activity. Cell, 75, 13-23.
2. Mermall, V., Post, P.L. and Mooscker, M.S. (1998) Unconventional myosins in membrane traffic, cell movement and signal transduction. Science, 279, 527-533.
3. Russell, E.S. (1949) A quantitative histological study of the pigment found in the coat-color mutants of the mouse IV. The nature of the effect of genic-substitution in five major series. Genetics, 34, 146-166.
4. Huang, J.-D., Cope, M.J., Mermall, V., Strobel, M.C., Kendrick-Jones, J., Russell, L.B., Mooseker, M.S., Copeland, N.G. and Jenkins, N.A. (1998) Molecular genetic dissection of mouse unconventional myosin-VA: head region mutations. Genetics, 148, 1951-1961.
5. Wu, X., Bowers, B., Rao, K., Wei, Q. and Hammer III, J.A. (1998) Visualization of melanosome dynamics within wild-type and dilute melanocytes suggests a paradigm for myosin V function in vivo. J. Cell Biol. 143, 1899-1918.
6. Dekker-Ohno, K., Hayasaka, S., Takagishi, Y., Oda, S., Wakasugi, N., Mikoshiba, K., Inouye, M. and Yamamura, H. (1996) Endoplasmic reticulum is missing in dendritic spines of Purkinje cells of the ataxic mutant rat. Brain Res., 714, 226-230.
7. 2+ store in the dendritic spine of Purkinje cells in mice. Neurosci. Lett., 215, 169-172.
8. 2+-dependent interaction with the synaptobrevin-synaptophysin complex. J. Cell Biol., 137, 1589-1601.
9. Evans, L.L., Hammer, J. and Bridgeman, P.C. (1997) Subcellular localization of myosin V in nerve growth cones and outgrowth from dilute-lethal neurons. J. Cell Sci., 110, 439-449.
10. Pastural, E., Barrat, F.J., Dufourcq-Lagelouse, R., Certain, S., Sanal, O., Jabado, N., Seger, R., Griscelli, C., Fischer, A. and de Saint Basile, G. (1999) Griscelli disease maps to chromosome 15q2l and is associated with mutations in the myosin-Va gene. Nature Genet., 16. 289-292 [Erratum (1999) Nature Genet., 23, 373].
11. Lambright, D.G., Sondek, J., Bohm, A., Skiba, N.P., Hamm, H.E. and Sigler P.B. (1996) The 2.0 A crystal structure of a heterotrimeric G protein. Nature, 379, 311-319.
12. Wall, M.A., Coleman, D.E., Lee, E., Iniguez-Lluhi, J.A., Posner, B.A., Oilman, A.G. and Sprang, S.R. (1995) The structure of the G protein heterotrimer Gi α1 β1 γ2. Cell, 83, 1047-1058.
13. 20J and radiation-induced dilute prenatal lethal Aa2 alleles. Mol. Cell. Biol., 10, 501-509.
14. Rowe, L.B., Nadeau, J.H., Turner, R., Frankel, W.N., Letts, V.A., Eppig, J.T., Ko, M.S., Thurston, S.J. and Birkenmeier, E.H. (1994) Maps from two interspecific backcross DNA panels available as a community genetic mapping resource. Mamm. Genome, 5, 253-274.
15. Hayashi, T., Motulsky, A.G. and Deeb, S.S. (1999) Position of a 'green-red' hybrid gene in the visual pigment array determines colour-vision phenotype. Nature Genet., 22, 90-93.
16. Taylor, B.A., Navin, A., Skryabin, B.V. and Brosius, J. (1997) Localization of the mouse gene (Bcl) encoding neural BC1 RNA near the fibroblast growth factor 3 locus (Fgf3) on distal chromosome 7. Genomics, 44, 153-154.
17. Kass, D.H., Kim, J. and Deininger, P.L. (1996) Sporadic amplification of ID elements in rodents. J. Mol. Evol., 42, 7-14.
18. Brosius, J. (1999) RNAS from all categories generate retrosequences that may be exapted as novel genes or regulatory elements. Gene, 238, 115-134.
19. Reck-Peterson, S.L., Novick, P.J. and Mooseker, M.S. (1999) The tail of a yeast class V myosin. Myo2p, functions as a localization domain. Mol. Biol. Cell, 10, 1001-1017.
20. Mehta, A.D., Rock, R.S., Rief, M., Spudich, J.A., Mooseker, M.S. and Cheney, R.E. (1999) Myosin-V is processive actin-based motor. Nature, 400, 590-593.
21. Espindola, F., Cheney, R.E., King, S.M., Suter, D.M. and Mooseker, M.S. (1996) Myosin-V and dynein share a similar light chain. Mol. Biol. Cell. 7, 372a.
22. Benashski, S.E., Harrison, A., Patel-King, R.S. and King, S.M. (1997) Dimerization of the highly conserved light chain shared by dynein and myosin V. J. Biol. Chem., 272, 20929-20935.
23. Watson, A.J., Katz, A. and Simon, M.I. (1994) A fifth member of the mammalian G-protein β-subunit family. J. Biol. Chem., 269, 22150-22156.
24. Jones, P.C., Lombardi, S.J. and Cockett, M.I. (1998) Cloning and tissue distribution of the human G protein β5 cDNA. Biochim. Biophys. Acta, 1402, 288-291.
25. Sudhof, T.C. Goldstein, J.L., Brown, M.S. and Russell, D.W. (1985) The LDL receptor gene: a mosaic of exons shared with different proteins. Science, 228, 815-822.
26. Tashian, R.E., Bergenhem, N.C.H. and Carter, N.D. (2000) Carbonic anhydrase (CA)-related proteins, and transmembrane proteins with CA or CA-like domains. In Chegwidden, W.R., Carter, N.D. and Edwards, Y.H. (eds). Carbonic Anhydrase: New Horizons. Birkhauser, Basel, in press.
27. I20J, of the murine dilute locus. Proc. Natl Acad. Sci., 85, 8131-8135.
28. Taylor, B., Navin, A. and Phillips, S. (1994) PCR-amplification of simple sequence repeat variants from pooled DNA samples for rapidly mapping new mutations of the mouse. Genomics, 21, 626-632.
29. Dietrich, W., Katz, H., Lincoln, S.E., Shin, H.S., Friedman, J., Dracopoli. N.C. and Lander, E.S. (1992) A genetic map of the mouse suitable for typing intraspecific crosses. Genetics, 131, 423-447.
30. 2+ channel subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse. Cell. 88, 385-392.