Bis(2-(acylamino)phenyl) disulfides, 2-(acylamino)benzenethiols, and S-(2-(acylamino)phenyl) alkanethioates as novel inhibitors of cholesteryl ester transfer protein

Journal of Medicinal Chemistry

Volumn 43, Issue 19, 2000, Pages 3566-3572

  Shinkai, H ^a   Maeda, K ^a   Yamasaki, T ^a   Okamoto, H ^a   Uchida, I ^a  

^a JT Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (ACYLAMINO)BENZENETHIOL DERIVATIVE; 2 METHYLPROPANETHIOIC ACID S [2 [1 (2 ETHYLBUTYL)CYCLOHEXYLCARBOXAMIDO]PHENYL] ESTER; [2 [[1 (2 ETHYLBUTYL)CYCLOHEXANE]CARBONYLAMINO]PHENYL] 2 METHYLPROPANETHIOIC ACID; APOLIPOPROTEIN B; BIS[2 (ACYLAMINO)PHENYL] DISULFIDE DERIVATIVE; CHOLESTEROL ESTER; CHOLESTEROL ESTER TRANSFER PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; ATHEROSCLEROSIS; BIOASSAY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DISULFIDE BOND; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; MALE; NONHUMAN; PLASMA; RABBIT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; CARRIER PROTEINS; CHOLESTEROL ESTER TRANSFER PROTEINS; CHOLESTEROL, HDL; CYSTEINE; DISULFIDES; GLYCOPROTEINS; HUMANS; MALE; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

EID: 0034699510     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000224s     Document Type: Article

References (15)

1. Plasma cholesterol ester transfer protein
2. Regulation Of cholesteryl ester transfer protein (CETP) activity: Review of in vitro and in vivo studies
3. Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein
4. Plasma lipid transfer protein as a determinant of the atherogenicity of monkey plasma lipoproteins
5. Increased transfer of cholesteryl esters from high-density lipoproteins to low density and very low-density lipoproteins in patients with angiographic evidence of coronary artery disease
6. Relationship of high-density lipoprotein subfractions and cholesteryl ester transfer protein in plasma to carotid artery wall thickness
7. Plasma lipid transfer proteins, high-density lipoproteins, and reverse cholesterol transport
8. Cholesteryl ester transfer protein: Friend or foe?
9. Decreased early atherosclerotic lesions in hypertriglyceridemic mice expressing cholestery ester transfer protein transgene
10. Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels
11. Molecular physiology of reverse cholesterol transport
12. Inactivation of cholesteryl ester transfer protein by cysteine modification
13. Inter-relationship of lipid transferred by the lipid-transfer protein isolated from human lipoprotein-deficient plasma
14. A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits
15. Inhibition of cholesterol ester transfer protein by CGS 25159 and changes in lipoproteins in hamsters