In search of a successful application of WR-1065. Active metabolite of amifostin in the prevention of mucositis;Op zoek naar een succesvolle toepassing van WR-1065. Actieve metaboliet van amifostine ter voorkoming van mucositis

Pharmaceutisch Weekblad

Volumn 135, Issue 16, 2000, Pages 566-570

  Theunissen, D J ^a,b   Koopmans, P ^a   Hospers, G A P ^c   Stokman, M A ^c   Groen, H J M ^c   Uges, D R A ^c  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b Apotheek van het Medisch Ctr R   (Netherlands)

^c NONE

Author keywords

Amifostine; Chromatography, ion exchange; Mouth mucosa; Mouthwashes; Mucositis; WR 1065

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; AMIFOSTINE; CITRIC ACID; EPIRUBICIN;

ARTICLE; DRUG EFFICACY; DRUG METABOLISM; ELECTROCHEMICAL DETECTION; HUMAN; MOUTH MUCOSA; MOUTHWASH; MUCOSA INFLAMMATION; RADIATION INJURY;

EID: 0034696997     PISSN: 00316911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Berger AM, Kilroy T. Oral complications in cancer therapy. In: De Vita VT, Hellman S, Rosenberg SA, red. Cancer principles and practice of oncology. 5e ed. Philadelphia: Lippincott. 1997:2714-23.
2. Delaney JP, Bonsack ME, Felemovicius I. Radioprotection of the rat small intestine with topical WR-2721. Cancer 1994;74:2379-84.
3. Ben-Josef E, Mesina J, Shaw LM. Topical administration of WR-2721 achieves high concentrations in the rectal wall. Rad Res 1995;143:107-10.
4. Montana GS, Anscher MS, Mansbach CM, et al. Topical application of WR-2721 to prevent radiation-induced proctosigmoiditis. Cancer 1992;69:2826-30.
5. Dendale R, Bourhis J, Diawara O, et al. Effect of systemic and topical administration of amifostine on radiation-induced mucositis in mice. Proc Am Soc Clin Oncol 1997;16:221.
6. Büntzel J, Küttner K, Russel L, et al. Selective cytoprotection by amifostine in the treatment of head and neck cancer with simultaneous radiochemotherapy. Ann Oncol 1998;9:505-9.
7. Wymenga ANM, Van der Graaf WTA, Spijkervet FLK, et al. A new in vitro assay for quantitation of chemotherapy-induced mucositis. Br J Cancer 1997;76:1062-6.
8. Korst AEC, Vermorken JB, Van der Vijgh WJF. High-performance liquid chromatographic assay using electrochemical detection for the combined measurement of amifostine, WR-1065 and the disulfides in plasma. J Chromatogr B Biomed Sci Appl 1997;12:167-74.
9. Shaw LM, Bonner H, Turrisi A, et al. A liquid chromatographic electrochemical assay for WR-2721 in human plasma. J Liq Chrom 1984;7:2447-65.
10. Shaw LM, Bonner HS, Turrisi A, et al. Measurement of WR-1065 in blood and tissue. J Liq Chrom 1986;9:845-59.
11. Calabro-Jones PM, Aguilera JA, Ward JF, et al. Uptake of WR-2721 derivatives by cells in culture: identification of the transported form of the drug. Cancer Res 1988;48:3634-40.
12. Calabro-Jones PM, Fahey RC, Smoluk, et al. Alkaline phosphatase promotes radioprotection and accumulation of WR-1065 in V79-171 cells incubated in medium containing WR-2721. Int J Radiat Biol 1985;47:23-7.