Differential stimulation by PGE2 and calcemic hormones of IL-6 in stromal/osteoblastic cells

Biochemical and Biophysical Research Communications

Volumn 270, Issue 3, 2000, Pages 1080-1085

  Gruber, Reinhard ^a   Nothegger, Gudrun ^a   Ho, Guan Min ^a   Willheim, Martin ^a   Peterlik, Meinrad ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

1,25 Dihydroxyvitamin D3; Bone resorption; Cytokines; Osteoclasts; Parathyroid hormone; Prostaglandins

Indexed keywords

DIHYDROXYCOLECALCIFEROL; INTERLEUKIN 6; MESSENGER RNA; PARATHYROID HORMONE; PROSTAGLANDIN E2;

ARTICLE; AUTOCRINE EFFECT; BONE MARROW CULTURE; CELL LINE; CELL STIMULATION; CONTROLLED STUDY; FIBROBLAST; MESENCHYME; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; STROMA CELL;

EID: 0034696816     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.2573     Document Type: Article

References (33)

1. Canalis E. Regulation of bone remodeling. Favus M. J. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 1993;33-37 Raven Press, New York.
2. Manolagas S. C., Jilka R. L. Bone marrow, cytokines, and bone remodeling: Emerging insights into the pathophysiology of osteoporosis. N. Engl. J. Med. 332:1995;305-311.
3. Jilka R. L., Hangoc G., Girasole G., Passeri G., Williams D. C., Abrams J. S., Boyce B., Broxmeyer H., Manolagas S. C. Increased osteoclast development after estrogen loss: Mediation by interleukin-6. Science. 257:1992;88-91.
4. Jilka R. L. Cytokines, bone remodeling, and estrogen deficiency: A 1998 update. Bone. 23:1999;75-81.
5. Roodman G. D., Kurihara N., Ohsaki Y., Kukita A., Hosking D., Demulder A., Smith J. F., Singer F. R. Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone. J. Clin. Invest. 89:1992;46-52.
6. Grey A., Mitnick M. A., Masiukiewicz U., Sun B. H., Rudikoff S., Jilka R. L., Manolagas S. C., Insogna K. A role for interleukin-6 in parathyroid hormone-induced bone resorption in vivo. Endocrinology. 140:1999;4683-4690.
7. Ohshima S., Saeki Y., Mima T., Sasai M., Nishioka K., Nomura S., Kopf M., Katada Y., Tanaka T., Suemura M., Kishimoto T. Interleukin 6 plays a key role in the development of antigen-induced arthritis. Proc. Natl. Acad. Sci. USA. 95:1998;8222-8226.
8. Langub M. C. Jr., Koszewski N. J., Turner H. V., Monier-Faugere M. C., Geng Z., Malluche H. H. Bone resorption and mRNA expression of IL-6 and IL-6 receptor in patients with renal osteodystrophy. Kidney Int. 50:1996;515-520.
9. Yoneda T., Nakai M., Moriyama K., Scott L., Ida N., Kunitomo T., Mundy G. R. Neutralizing antibodies to human interleukin 6 reverse hypercalcemia associated with a human squamous carcinoma. Cancer Res. 53:1993;737-740.
10. Poli V., Balena R., Fattori E., Markatos A., Yamamoto M., Tanaka H., Ciliberto G., Rodan G. A., Costantini F. Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J. 13:1994;1189-1196.
11. Otsuka T., Thacker J. D., Hogge D. E. The effects of interleukin 6 and interleukin 3 on early hematopoietic events in long-term cultures of human marrow. Exp. Hematol. 19:1991;1042-1048.
12. al-Humidan A., Ralston S. H., Hughes D. E., Chapman K., Aarden L., Russell R. G., Gowen M. Interleukin-6 does not stimulate bone resorption in neonatal mouse calvariae. J. Bone Miner. Res. 6:1991;3-8.
13. Lowik C. W., van-der-Pluijm G., Bloys H., Hoekman K., Bijvoet O. L., Aarden L. A., Papapoulos S. E. Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: A possible role of interleukin-6 in osteoclastogenesis. Biochem. Biophys. Res. Commun. 162:1989;1546-1552.
14. Tamura T., Udagawa N., Takahashi N., Miyaura C., Tanaka S., Yamada Y., Koishihara Y., Oshugi Y., Kumaki K., Taga T., Kishimoto T., Suda T. Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. Proc. Natl. Acad. Sci. USA. 90:1993;11924-11928.
15. Schiller C., Gruber R., Redlich K., Ho G-M., Katzgraber F., Willheim M., Pietschmann P., Peterlik M. 17β-Estradiol antagonizes effects of 1α,25-dihydroxyvitamin D3 on interleukin-6 production and osteoclast-like cell formation in mouse bone marrow primary cultures. Endocrinology. 138:1997;4567-4571.
16. 3 on interleukin-6-dependent osteoclast-like cell formation in mouse bone marrow cell cultures. Bone. 22:1998;341-346.
17. Sandhu J. S., Gorczynski R. M., Waddell J., Nguyen H., Squires J., Waddell J., Boynton E. L., Hozumi N. Effect of interleukin-6 secreted by engineered human stromal cells on osteoclasts in human bone. Bone. 24:1999;217-227.
18. Greenfield E. M., Shaw S. M., Gornik S. A., Banks M. A. Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption. J. Clin. Invest. 96:1995;1238-1244.
19. Udagawa N., Takahashi N., Katagiri T., Tamura T., Wada S., Findlay D. M., Martin T. J., Hirota H., Taga T., Kishimoto T., Suda T. Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. J. Exp. Med. 182:1995;1461-1468.
20. Taichman R. S., Emerson S. G. The role of osteoblasts in the hematopoietic microenvironment. Stem Cells. 16:1998;7-15.
21. Yasuda H., Shima N., Nakagawa N., Yamaguchi K., Kinosaki M., Mochizuki S., Tomoyasu A., Yano K., Goto M., Murakami A., Tsuda E., Morinaga T., Higashio K., Udagawa N., Takahashi N., Suda T. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc. Natl. Acad. Sci. USA. 95:1998;3597-3602.
22. Greenfield E. M., Gornik S. A., Horowitz M. C., Donahue H. J., Shaw S. M. Regulation of cytokine expression in osteoblasts by parathyroid hormone: Rapid stimulation of interleukin-6 and leukemia inhibitory factor mRNA. J. Bone. Miner. Res. 8:1993;1163-1171.
23. Kozawa O., Suzuki A., Tokuda H., Kaida T., Uematsu T. Interleukin-6 synthesis induced by prostaglandin E2: Cross-talk regulation by protein kinase. Bone. 22:1998;355-360.
24. Millet I., McCarthy T. L., Vignery A. A regulation of interleukin-6 production by prostaglandin E2 in fetal rat osteoblasts: Role of protein kinase A signaling pathway. J. Bone. Miner. Res. 13:1998;1092-1100.
25. Denizot Y., Trimoreau F., Praloran V. Effects of lipid mediators on the synthesis of leukaemia inhibitory factor and interleukin 6 by human bone marrow stromal cells. Cytokine. 10:1998;781-785.
26. 3. J. Bone Miner. Res. 7:1992;611-617.
27. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
28. Huang Y. F., Harrison J. R., Lorenzo J. A., Kream B. E. Parathyroid hormone induces interleukin-6 heterogeneous nuclear and messenger RNA expression in murine calvarial organ cultures. Bone. 23:1998;327-332.
29. Alonso S., Minty A., Bourlet Y., Buckingham M. Comparison of three actin-coding sequences in the mouse: Evolutionary relationships between the actin genes of warm-blooded vertebrates. J. Mol. Evol. 23:1986;11-22.
30. 3 of osteoclast differentiation and bone resorption in neonatal mouse parietal bones. Calcif. Tissue Int. 55:1994;114-119.
31. Stein G. S., Lian J. B., Owen T. A. Relationship of cell growth to the regulation of tissue-specific gene expression during ostgeoblast differentiation. FASEB J. 4:1990;3111-3123.
32. Ishimi Y., Miyaura C., Jin C. H., Akatsu T., Abe E., Nakamura Y., Yamaguchi A., Yoshiki S., Matsuda T., Hirano T., Kishimoto T., Suda T. IL-6 is produced by osteoblasts and induces bone resorption. J. Immunol. 145:1990;3297-3303.
33. Kozawa O., Tokuda H., Kaida T., Matsuno H., Uematsu T. Effect of vitamin D3 on interleukin-6 synthesis induced by prostaglandins in osteoblasts. Prostaglandins Leukotrienes Essent. Fatty Acids. 58:1998;119-123.