Synthesis of the fatty sterol bound protein for a new sterol antibody

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 4, 2000, Pages 357-359

  Kim, Byung Ju ^a   Yamada, Satoshi ^b   Funada, Tadashi ^b   Kadoma, Yoshihito ^b   Morita, Hiroyuki ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b NOF Corporation   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; KEYHOLE LIMPET HEMOCYANIN; STEROL; STEROL ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; CROSS LINKING; DRUG SYNTHESIS; NONHUMAN;

ADJUVANTS, IMMUNOLOGIC; ALBUMINS; ANIMALS; ANTIBODIES; ANTIBODY FORMATION; ANTIGENS; CROSS-LINKING REAGENTS; HEMOCYANIN; MICE; PREGNENOLONE; PROTEINS; STEROLS;

EID: 0034696060     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00694-0     Document Type: Article

References (19)

1. Goldstein J.L., Brown M.S. Nature. 343:1990;425.
2. Brown M.S., Goldstein J.L., Krieger M., Ho Y.K., Anderson R.G.W. J. Cell. Biol. 82:1979;597.
3. Ross R. Nature. 362:1993;801.
4. Klinker A.M., Waites C.R., Kerns W.D., Bulgelski P.J. J. Histochem. Cytochem. 43:1995;1071.
5. Smith S.C. Jr. Am. J. Cardiol. 80(8B):1997;10H.
6. Shain, S. A.; Lin, A. L.; McGill, Jr., H. C. In Steroid Receptors and Disease; Cancer, Autoimmune, Bone, and Circulatory Disorders; Sheridan, P. J., Blum, K., Trachtenberg, M. C., Eds.; Marcel Dekker; New York, 1988; Chapter 22.
7. Washburn, S. A.; Wagner, J. D.; Adams, M. R.; Clarkson, T. B. In Pharmacology of the Contraceptive Steroids; Goldzieher, J. W., Fotherby, K., Eds.; Raven Press: New York, 1994; Chapter 22.
8. Mijares A., Cargill D.I., Glasel J.A., Lieberman S. J. Org. Chem. 32:1967;810.
9. Green, T. W.; Wuts, P. G. M. Protective Groups in Organic Synthesis, 2nd ed., John Wiley & Sons: New York, 1991; references for protection and deprotection of OH group cited therein.
10. Bordwell F.G., Hewett W.A. J. Am. Chem. Soc. 79:1957;3493.
11. Neureiter N.P., Bordwell F.G. J. Am. Chem. Soc. 82:1960;5354.
12. Nickisch K., Bittler D., Laurent H., Losert W., Casals-Stenzel J., Nishino Y., Schillinger E., Wiechert R. J. Med. Chem. 30:1987;1430.
13. Broxterman Q.B., Kaptein B., Kamphuis J., Schoemaker H.E. J. Org. Chem. 57:1992;6286.
14. Tseng T.-C., Wu M.-J. Tetrahedron Asymmetry. 6:1995;1633.
15. Patel K.M., Sklar L.A., Currie R., Pownall H.J., Morrisett J.D., Sparrow J.T. Lipids. 14:1979;816.
16. Kitagawa T., Aikawa T. J. Biochem. (Tokyo). 79:1976;233.
17. Madison L.D., Rosenzweig S.A., Jamieson J.D. J. Biol. Chem. 259:1984;14818.
18. Carroll T.R., Davison A., Jones A.G. J. Med. Chem. 29:1986;1821.
19. 2). One hour later, after the removal of the excess fatty sterol 9 and DMF by passing through a Sephadex G-25 column, the mixture of the modified protein and unconjugated protein was directly used for the immunizing experiment in mice. The production procedure of monoclonal antibody was followed by the known procedure. See, for example, Zhang, S.; Graeber, L. A.; Helling, F.; Ragupathi, G.; Adluri, S.; Lloyd, K. O.; Livingston, P. O. Cancer Res. 1996, 56, 3315.