Equilibrium position, kinetics, and reactor concepts for the adipyl-7-ADCA-hydrolysis process

Biotechnology and Bioengineering

Volumn 70, Issue 6, 2000, Pages 654-661

  Schroen C G P H ^a   VandeWiel, S ^a   Kroon, P J ^a   DeVroom, E ^b   Janssen, A E M ^a   Tramper, J ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b DSM RESOLVE   (Netherlands)

Author keywords

Antibiotic; Enzyme kinetics; Equilibrium position; Hydrolysis process; Reactor concepts

Indexed keywords

CARBOXYLIC ACIDS; CATALYSIS; CHEMICAL REACTORS; ENZYMES; FERMENTATION; HYDROLYSIS; PH EFFECTS; RATE CONSTANTS; THERMAL EFFECTS;

AMINO-DEACETOXYCEPHALOSPORANIC ACID;

ANTIBIOTICS;

ADIPIC ACID; AMIDASE; CEPHALOSPORANIC ACID DERIVATIVE; PENICILLIN G;

ARTICLE; ENTHALPY; FERMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; KINETICS; REACTOR;

EID: 0034694932     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0290(20001220)70:6<654::AID-BIT7>3.0.CO;2-3     Document Type: Article

References (18)

1. Biocatalysis and process integration in synthesis of semi-synthetic antibiotics
2. Penicillin acylase in the industrial production of β-lactam antibiotics
3. Two-step immobilized enzyme conversion of cephalosporin C to 7-aminocephalosporanic acid
4. Feasibility of the thermodynamically controlled synthesis of amoxycillin
5. Penicillin acylase has a single-amino-acid catalytic centre
6. Thermodynamically controlled synthesis of β-lactam antibiotics. Equilibrium position and side-chain properties
7. pH gradients in immobilized amidases and their influence on rates and yields of β-lactam hydrolysis
8. Kinetic study of penicillin acylase from Alcaligenes faecalis
9. Enzymatic synthesis of β-lactam antibiotics: A thermodynamic background
10. Industrial transformations of penicillins and cephalosporins
11. Comparative stability of cephalosporins in aqueous solution: Kinetics and mechanisms of degradation
12. Comparative stabilities of cephalosporins in aqueous solution